Antioxidative, anti-inflammatory potentials and phytochemical profile of Commiphora africana (A. Rich.) Engl. (Burseraceae) and Loeseneriella africana (Willd.) (Celastraceae) stem leaves extracts
Objective: To assess the antioxidant and anti-inflammatory activities as well as to determine the flavonoids and phenolic acids content of active fractions. Methods: Two medicinal plant samples were extracted successively in Soxhlet apparatus with n-hexane, dichloromethane, acetonitrile, ethyl aceta...
Published in: | Asian Pacific Journal of Tropical Biomedicine |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2016
|
Subjects: | |
Online Access: | https://doi.org/10.1016/j.apjtb.2016.06.001 https://doaj.org/article/b5cfff51152f49a9b258a2236fd4b37e |
id |
ftdoajarticles:oai:doaj.org/article:b5cfff51152f49a9b258a2236fd4b37e |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:b5cfff51152f49a9b258a2236fd4b37e 2023-05-15T15:09:31+02:00 Antioxidative, anti-inflammatory potentials and phytochemical profile of Commiphora africana (A. Rich.) Engl. (Burseraceae) and Loeseneriella africana (Willd.) (Celastraceae) stem leaves extracts Moussa Compaoré Roland Nâg-Tiéro Meda Sahabi Bakasso Laurian Vlase Martin Kiendrebeogo 2016-08-01T00:00:00Z https://doi.org/10.1016/j.apjtb.2016.06.001 https://doaj.org/article/b5cfff51152f49a9b258a2236fd4b37e EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169116300028 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2016.06.001 https://doaj.org/article/b5cfff51152f49a9b258a2236fd4b37e Asian Pacific Journal of Tropical Biomedicine, Vol 6, Iss 8, Pp 665-670 (2016) Commiphora africana Loeseneriella africana Antioxidant Anti-inflammation Phenolics HPLC-MS Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2016 ftdoajarticles https://doi.org/10.1016/j.apjtb.2016.06.001 2022-12-31T06:24:26Z Objective: To assess the antioxidant and anti-inflammatory activities as well as to determine the flavonoids and phenolic acids content of active fractions. Methods: Two medicinal plant samples were extracted successively in Soxhlet apparatus with n-hexane, dichloromethane, acetonitrile, ethyl acetate, methanol and n-butanol. Five methods were used to evaluate the antioxidant activity. Anti-inflammatory activity was done through the inhibition of the cyclooxygenase enzymes (COX-1 and COX-2). Polyphenolic compounds were analyzed by using a spectrophotometrical and high performance liquid chromatography-mass spectrometry (HPLC-MS) methods. Results: The data showed that the stem leaves extracts of Commiphora africana and Loeseneriella africana possessed significant in vitro antioxidant and anti-inflammatory activities. Polar extracts had radical scavenging effects and they reduced iron (III). The prostaglandin production was significantly stopped by acetonitrile and methanol extracts. These biological activities were supported by some bioactive compounds quantified by using the HPLC-MS. p-Coumaric acid, ferulic acid, isoquercitrin, quercitrin, quercetin, rutin, kaempferol and apigenin were the most metabolites quantified. Conclusions: The present study may explain the effectiveness of plants in traditional medicine of Burkina Faso, singularly Commiphora africana and Loeseneriella africana. The next investigation was to sub-fractionate the methanol fraction in order to isolate new antioxidant and/or anti-inflammatory compounds. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 6 8 665 670 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Commiphora africana Loeseneriella africana Antioxidant Anti-inflammation Phenolics HPLC-MS Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Commiphora africana Loeseneriella africana Antioxidant Anti-inflammation Phenolics HPLC-MS Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Moussa Compaoré Roland Nâg-Tiéro Meda Sahabi Bakasso Laurian Vlase Martin Kiendrebeogo Antioxidative, anti-inflammatory potentials and phytochemical profile of Commiphora africana (A. Rich.) Engl. (Burseraceae) and Loeseneriella africana (Willd.) (Celastraceae) stem leaves extracts |
topic_facet |
Commiphora africana Loeseneriella africana Antioxidant Anti-inflammation Phenolics HPLC-MS Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To assess the antioxidant and anti-inflammatory activities as well as to determine the flavonoids and phenolic acids content of active fractions. Methods: Two medicinal plant samples were extracted successively in Soxhlet apparatus with n-hexane, dichloromethane, acetonitrile, ethyl acetate, methanol and n-butanol. Five methods were used to evaluate the antioxidant activity. Anti-inflammatory activity was done through the inhibition of the cyclooxygenase enzymes (COX-1 and COX-2). Polyphenolic compounds were analyzed by using a spectrophotometrical and high performance liquid chromatography-mass spectrometry (HPLC-MS) methods. Results: The data showed that the stem leaves extracts of Commiphora africana and Loeseneriella africana possessed significant in vitro antioxidant and anti-inflammatory activities. Polar extracts had radical scavenging effects and they reduced iron (III). The prostaglandin production was significantly stopped by acetonitrile and methanol extracts. These biological activities were supported by some bioactive compounds quantified by using the HPLC-MS. p-Coumaric acid, ferulic acid, isoquercitrin, quercitrin, quercetin, rutin, kaempferol and apigenin were the most metabolites quantified. Conclusions: The present study may explain the effectiveness of plants in traditional medicine of Burkina Faso, singularly Commiphora africana and Loeseneriella africana. The next investigation was to sub-fractionate the methanol fraction in order to isolate new antioxidant and/or anti-inflammatory compounds. |
format |
Article in Journal/Newspaper |
author |
Moussa Compaoré Roland Nâg-Tiéro Meda Sahabi Bakasso Laurian Vlase Martin Kiendrebeogo |
author_facet |
Moussa Compaoré Roland Nâg-Tiéro Meda Sahabi Bakasso Laurian Vlase Martin Kiendrebeogo |
author_sort |
Moussa Compaoré |
title |
Antioxidative, anti-inflammatory potentials and phytochemical profile of Commiphora africana (A. Rich.) Engl. (Burseraceae) and Loeseneriella africana (Willd.) (Celastraceae) stem leaves extracts |
title_short |
Antioxidative, anti-inflammatory potentials and phytochemical profile of Commiphora africana (A. Rich.) Engl. (Burseraceae) and Loeseneriella africana (Willd.) (Celastraceae) stem leaves extracts |
title_full |
Antioxidative, anti-inflammatory potentials and phytochemical profile of Commiphora africana (A. Rich.) Engl. (Burseraceae) and Loeseneriella africana (Willd.) (Celastraceae) stem leaves extracts |
title_fullStr |
Antioxidative, anti-inflammatory potentials and phytochemical profile of Commiphora africana (A. Rich.) Engl. (Burseraceae) and Loeseneriella africana (Willd.) (Celastraceae) stem leaves extracts |
title_full_unstemmed |
Antioxidative, anti-inflammatory potentials and phytochemical profile of Commiphora africana (A. Rich.) Engl. (Burseraceae) and Loeseneriella africana (Willd.) (Celastraceae) stem leaves extracts |
title_sort |
antioxidative, anti-inflammatory potentials and phytochemical profile of commiphora africana (a. rich.) engl. (burseraceae) and loeseneriella africana (willd.) (celastraceae) stem leaves extracts |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2016 |
url |
https://doi.org/10.1016/j.apjtb.2016.06.001 https://doaj.org/article/b5cfff51152f49a9b258a2236fd4b37e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 6, Iss 8, Pp 665-670 (2016) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169116300028 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2016.06.001 https://doaj.org/article/b5cfff51152f49a9b258a2236fd4b37e |
op_doi |
https://doi.org/10.1016/j.apjtb.2016.06.001 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
6 |
container_issue |
8 |
container_start_page |
665 |
op_container_end_page |
670 |
_version_ |
1766340692147175424 |