Effects of larval rearing substrates on some life-table parameters of Lutzomyia longipalpis sand flies.

• Published in: PLOS Neglected Tropical Diseases
• Main Authors: Kelsilandia Aguiar Martins, Maria Helena de Athayde Meirelles, Tiago Feitosa Mota, Ibrahim Abbasi, Artur Trancoso Lopo de Queiroz, Claudia Ida Brodskyn, Patrícia Sampaio Tavares Veras, Deborah Bittencourt Mothé Fraga, Alon Warburg
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2021
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic
• Online Access: https://doi.org/10.1371/journal.pntd.0009034; https://doaj.org/article/b5b2b89517104d82a280a2f0a3023408

Sand flies are the insects responsible for transmitting Leishmania parasites, the causative agents of leishmaniasis in humans. However, the effects of sand fly breeding sites on their biology and ecology remain poorly understood. Herein, we studied how larval nutrition associated with putative breeding sites of the sand fly Lutzomyia longipalpis affects their oviposition, development, microbiome, and susceptibility to Leishmania by rearing L. longipalpis on substrates collected from an endemic area for leishmaniasis in Brazil. The results showed that female L. longipalpis select the oviposition site based on its potential to promote larval maturation and while composting cashew leaf litter hindered the development, larvae reared on chicken feces developed rapidly. Typical gut microbial profiles were found in larvae reared upon cashew leaf litter. Adult females from larvae reared on substrate collected in chicken coops were infected with Leishmania infantum, indicating that they were highly susceptible to the parasite. In conclusion, the larval breeding sites can exert an important role in the epidemiology of leishmaniasis.