Validity of self-reported use of sulphadoxine-pyrimethamine intermittent presumptive treatment during pregnancy (IPTp): a cross-sectional study
Abstract Background Malaria in pregnancy is a major health problem that can cause maternal anaemia, stillbirth, spontaneous abortion, low birth weight and intra-uterine stunting. The WHO recommends use of sulphadoxine-pyrimethamine (SP) for intermittent preventive treatment of malaria during pregnan...
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ftdoajarticles:oai:doaj.org/article:b5842a3e9a1c406eac6f813988b886e8 2023-05-15T15:18:06+02:00 Validity of self-reported use of sulphadoxine-pyrimethamine intermittent presumptive treatment during pregnancy (IPTp): a cross-sectional study Namusoke Fatuma Ntale Muhammad Wahlgren Mats Kironde Fred Mirembe Florence 2012-09-01T00:00:00Z https://doi.org/10.1186/1475-2875-11-310 https://doaj.org/article/b5842a3e9a1c406eac6f813988b886e8 EN eng BMC http://www.malariajournal.com/content/11/1/310 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-310 1475-2875 https://doaj.org/article/b5842a3e9a1c406eac6f813988b886e8 Malaria Journal, Vol 11, Iss 1, p 310 (2012) Pregnancy malaria Intermittent presumptive treatment Self-reported data Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2012 ftdoajarticles https://doi.org/10.1186/1475-2875-11-310 2022-12-31T07:23:58Z Abstract Background Malaria in pregnancy is a major health problem that can cause maternal anaemia, stillbirth, spontaneous abortion, low birth weight and intra-uterine stunting. The WHO recommends use of sulphadoxine-pyrimethamine (SP) for intermittent preventive treatment of malaria during pregnancy (IPTp) in endemic areas. Towards monitoring and assessing IPTp coverage in the population, the Roll Back Malaria Partnership recommends the use of self-reported data. The aim of this study was to assess the validity of self-reported IPTp by testing for sulphadoxine in maternal blood at delivery. Methods Two hundred and four pregnant women were consented and enrolled in a cross-sectional study in Mulago National Referral Hospital in Kampala Uganda. - Participants who reported a history of taking sulpha-containing drugs like co-trimoxazole , those who were not sure of dates relating to last menstrual period or who took IPTp within the first 20 weeks of gestation were excluded from the study. Data on demographic characteristics, obstetric history, and delivery outcome were collected. At birth, maternal venous blood was taken off aseptically and used to make thick blood smears for malaria parasites and plasma for determining sulphadoxine using high performance liquid chromatography (HPLC). Results Of 120 participants who self reported to have used IPTp, 35 (29.2%) tested positive for sulphadoxine by HPLC, while 63 (75%) of 84 patients who reported not having used IPTp tested negative for sulphadoxine. Participants possessing post-primary education were more likely to have reported using IPTp. The low agreement (kappa coefficient = 0.037) between self-report and actual presence of the drug in the blood casts doubt on the validity of self-reported data in estimating IPTp coverage. Conclusions The results of this study question the accuracy of self-reported data in estimating IPTp coverage in the population. More studies on validity of self reported data are recommended. Since the validity of IPTp self reports is vital ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 11 1 310 |
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English |
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Pregnancy malaria Intermittent presumptive treatment Self-reported data Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Pregnancy malaria Intermittent presumptive treatment Self-reported data Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Namusoke Fatuma Ntale Muhammad Wahlgren Mats Kironde Fred Mirembe Florence Validity of self-reported use of sulphadoxine-pyrimethamine intermittent presumptive treatment during pregnancy (IPTp): a cross-sectional study |
topic_facet |
Pregnancy malaria Intermittent presumptive treatment Self-reported data Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Malaria in pregnancy is a major health problem that can cause maternal anaemia, stillbirth, spontaneous abortion, low birth weight and intra-uterine stunting. The WHO recommends use of sulphadoxine-pyrimethamine (SP) for intermittent preventive treatment of malaria during pregnancy (IPTp) in endemic areas. Towards monitoring and assessing IPTp coverage in the population, the Roll Back Malaria Partnership recommends the use of self-reported data. The aim of this study was to assess the validity of self-reported IPTp by testing for sulphadoxine in maternal blood at delivery. Methods Two hundred and four pregnant women were consented and enrolled in a cross-sectional study in Mulago National Referral Hospital in Kampala Uganda. - Participants who reported a history of taking sulpha-containing drugs like co-trimoxazole , those who were not sure of dates relating to last menstrual period or who took IPTp within the first 20 weeks of gestation were excluded from the study. Data on demographic characteristics, obstetric history, and delivery outcome were collected. At birth, maternal venous blood was taken off aseptically and used to make thick blood smears for malaria parasites and plasma for determining sulphadoxine using high performance liquid chromatography (HPLC). Results Of 120 participants who self reported to have used IPTp, 35 (29.2%) tested positive for sulphadoxine by HPLC, while 63 (75%) of 84 patients who reported not having used IPTp tested negative for sulphadoxine. Participants possessing post-primary education were more likely to have reported using IPTp. The low agreement (kappa coefficient = 0.037) between self-report and actual presence of the drug in the blood casts doubt on the validity of self-reported data in estimating IPTp coverage. Conclusions The results of this study question the accuracy of self-reported data in estimating IPTp coverage in the population. More studies on validity of self reported data are recommended. Since the validity of IPTp self reports is vital ... |
format |
Article in Journal/Newspaper |
author |
Namusoke Fatuma Ntale Muhammad Wahlgren Mats Kironde Fred Mirembe Florence |
author_facet |
Namusoke Fatuma Ntale Muhammad Wahlgren Mats Kironde Fred Mirembe Florence |
author_sort |
Namusoke Fatuma |
title |
Validity of self-reported use of sulphadoxine-pyrimethamine intermittent presumptive treatment during pregnancy (IPTp): a cross-sectional study |
title_short |
Validity of self-reported use of sulphadoxine-pyrimethamine intermittent presumptive treatment during pregnancy (IPTp): a cross-sectional study |
title_full |
Validity of self-reported use of sulphadoxine-pyrimethamine intermittent presumptive treatment during pregnancy (IPTp): a cross-sectional study |
title_fullStr |
Validity of self-reported use of sulphadoxine-pyrimethamine intermittent presumptive treatment during pregnancy (IPTp): a cross-sectional study |
title_full_unstemmed |
Validity of self-reported use of sulphadoxine-pyrimethamine intermittent presumptive treatment during pregnancy (IPTp): a cross-sectional study |
title_sort |
validity of self-reported use of sulphadoxine-pyrimethamine intermittent presumptive treatment during pregnancy (iptp): a cross-sectional study |
publisher |
BMC |
publishDate |
2012 |
url |
https://doi.org/10.1186/1475-2875-11-310 https://doaj.org/article/b5842a3e9a1c406eac6f813988b886e8 |
geographic |
Arctic |
geographic_facet |
Arctic |
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Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 11, Iss 1, p 310 (2012) |
op_relation |
http://www.malariajournal.com/content/11/1/310 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-310 1475-2875 https://doaj.org/article/b5842a3e9a1c406eac6f813988b886e8 |
op_doi |
https://doi.org/10.1186/1475-2875-11-310 |
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Malaria Journal |
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11 |
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310 |
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