Long–term spatial memory and morphological changes in hippocampus of Wistar rats exposed to smoke from Carica papaya leaves
Objective: To investigate the effects of smoking of dried leaves of Carica papaya (pawpaw) based on ethnopharmacological information which indicated that smoking of papaya leaves could influence motor performance and learning. Methods: Twenty-four rats were used for the study, and were grouped into...
Published in: | Asian Pacific Journal of Tropical Biomedicine |
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Wolters Kluwer Medknow Publications
2014
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ftdoajarticles:oai:doaj.org/article:b4dac64858cd49c4aeddc560f1a4eff2 2023-05-15T15:08:38+02:00 Long–term spatial memory and morphological changes in hippocampus of Wistar rats exposed to smoke from Carica papaya leaves Aboyeji Lukuman Oyewole Bamidele Victor Owoyele 2014-03-01T00:00:00Z https://doi.org/10.1016/S2221-1691(14)60234-3 https://doaj.org/article/b4dac64858cd49c4aeddc560f1a4eff2 EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169115301957 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/S2221-1691(14)60234-3 https://doaj.org/article/b4dac64858cd49c4aeddc560f1a4eff2 Asian Pacific Journal of Tropical Biomedicine, Vol 4, Iss 3, Pp 213-218 (2014) Maze Spatial memory Smoking Carica papaya Rats Hippocampus Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2014 ftdoajarticles https://doi.org/10.1016/S2221-1691(14)60234-3 2022-12-31T02:44:57Z Objective: To investigate the effects of smoking of dried leaves of Carica papaya (pawpaw) based on ethnopharmacological information which indicated that smoking of papaya leaves could influence motor performance and learning. Methods: Twenty-four rats were used for the study, and were grouped into four groups. Groups 1 served as the control (not exposed to papaya leaves smoke), while Groups 2, 3 and 4 were exposed to smoke from 6.25 g, 12.50 g and 18.75 g of dry pawpaw leaves respectively in a smoking chamber twice daily for 21 d with each exposure lasting for 3 min. Lastly, hippocampus was harvested in each group for histological study. Results: The results showed that there were significant (P<0.05) increases in mean of recall latencies of long-term spatial memory in the animal administered the high dose while the other groups had significantly (P<0.05) lower frequencies. Histological investigation showed signs of mild neural degeneration in high dose group and hypochromic appearance of the Nissl substance in all treated groups. Conclusions: In conclusion, the findings from this study has demonstrated that smoking of papaya leaves has the ability to maintain an intact long-term spatial memory at all doses but retrieving such memory is faster with the low and medium dosages. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 4 3 213 218 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Maze Spatial memory Smoking Carica papaya Rats Hippocampus Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
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Maze Spatial memory Smoking Carica papaya Rats Hippocampus Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Aboyeji Lukuman Oyewole Bamidele Victor Owoyele Long–term spatial memory and morphological changes in hippocampus of Wistar rats exposed to smoke from Carica papaya leaves |
topic_facet |
Maze Spatial memory Smoking Carica papaya Rats Hippocampus Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To investigate the effects of smoking of dried leaves of Carica papaya (pawpaw) based on ethnopharmacological information which indicated that smoking of papaya leaves could influence motor performance and learning. Methods: Twenty-four rats were used for the study, and were grouped into four groups. Groups 1 served as the control (not exposed to papaya leaves smoke), while Groups 2, 3 and 4 were exposed to smoke from 6.25 g, 12.50 g and 18.75 g of dry pawpaw leaves respectively in a smoking chamber twice daily for 21 d with each exposure lasting for 3 min. Lastly, hippocampus was harvested in each group for histological study. Results: The results showed that there were significant (P<0.05) increases in mean of recall latencies of long-term spatial memory in the animal administered the high dose while the other groups had significantly (P<0.05) lower frequencies. Histological investigation showed signs of mild neural degeneration in high dose group and hypochromic appearance of the Nissl substance in all treated groups. Conclusions: In conclusion, the findings from this study has demonstrated that smoking of papaya leaves has the ability to maintain an intact long-term spatial memory at all doses but retrieving such memory is faster with the low and medium dosages. |
format |
Article in Journal/Newspaper |
author |
Aboyeji Lukuman Oyewole Bamidele Victor Owoyele |
author_facet |
Aboyeji Lukuman Oyewole Bamidele Victor Owoyele |
author_sort |
Aboyeji Lukuman Oyewole |
title |
Long–term spatial memory and morphological changes in hippocampus of Wistar rats exposed to smoke from Carica papaya leaves |
title_short |
Long–term spatial memory and morphological changes in hippocampus of Wistar rats exposed to smoke from Carica papaya leaves |
title_full |
Long–term spatial memory and morphological changes in hippocampus of Wistar rats exposed to smoke from Carica papaya leaves |
title_fullStr |
Long–term spatial memory and morphological changes in hippocampus of Wistar rats exposed to smoke from Carica papaya leaves |
title_full_unstemmed |
Long–term spatial memory and morphological changes in hippocampus of Wistar rats exposed to smoke from Carica papaya leaves |
title_sort |
long–term spatial memory and morphological changes in hippocampus of wistar rats exposed to smoke from carica papaya leaves |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2014 |
url |
https://doi.org/10.1016/S2221-1691(14)60234-3 https://doaj.org/article/b4dac64858cd49c4aeddc560f1a4eff2 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 4, Iss 3, Pp 213-218 (2014) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169115301957 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/S2221-1691(14)60234-3 https://doaj.org/article/b4dac64858cd49c4aeddc560f1a4eff2 |
op_doi |
https://doi.org/10.1016/S2221-1691(14)60234-3 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
4 |
container_issue |
3 |
container_start_page |
213 |
op_container_end_page |
218 |
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1766339962374979584 |