Ebolaviruses: New roles for old proteins.
In 2014, the world witnessed the largest Ebolavirus outbreak in recorded history. The subsequent humanitarian effort spurred extensive research, significantly enhancing our understanding of ebolavirus replication and pathogenicity. The main functions of each ebolavirus protein have been studied exte...
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ftdoajarticles:oai:doaj.org/article:b4662f4464cb4852b25a96bf0b13aad0 2023-05-15T15:04:08+02:00 Ebolaviruses: New roles for old proteins. Diego Cantoni Jeremy S Rossman 2018-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006349 https://doaj.org/article/b4662f4464cb4852b25a96bf0b13aad0 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5933699?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006349 https://doaj.org/article/b4662f4464cb4852b25a96bf0b13aad0 PLoS Neglected Tropical Diseases, Vol 12, Iss 5, p e0006349 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006349 2022-12-31T15:58:38Z In 2014, the world witnessed the largest Ebolavirus outbreak in recorded history. The subsequent humanitarian effort spurred extensive research, significantly enhancing our understanding of ebolavirus replication and pathogenicity. The main functions of each ebolavirus protein have been studied extensively since the discovery of the virus in 1976; however, the recent expansion of ebolavirus research has led to the discovery of new protein functions. These newly discovered roles are revealing new mechanisms of virus replication and pathogenicity, whilst enhancing our understanding of the broad functions of each ebolavirus viral protein (VP). Many of these new functions appear to be unrelated to the protein's primary function during virus replication. Such new functions range from bystander T-lymphocyte death caused by VP40-secreted exosomes to new roles for VP24 in viral particle formation. This review highlights the newly discovered roles of ebolavirus proteins in order to provide a more encompassing view of ebolavirus replication and pathogenicity. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 12 5 e0006349 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Diego Cantoni Jeremy S Rossman Ebolaviruses: New roles for old proteins. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
In 2014, the world witnessed the largest Ebolavirus outbreak in recorded history. The subsequent humanitarian effort spurred extensive research, significantly enhancing our understanding of ebolavirus replication and pathogenicity. The main functions of each ebolavirus protein have been studied extensively since the discovery of the virus in 1976; however, the recent expansion of ebolavirus research has led to the discovery of new protein functions. These newly discovered roles are revealing new mechanisms of virus replication and pathogenicity, whilst enhancing our understanding of the broad functions of each ebolavirus viral protein (VP). Many of these new functions appear to be unrelated to the protein's primary function during virus replication. Such new functions range from bystander T-lymphocyte death caused by VP40-secreted exosomes to new roles for VP24 in viral particle formation. This review highlights the newly discovered roles of ebolavirus proteins in order to provide a more encompassing view of ebolavirus replication and pathogenicity. |
format |
Article in Journal/Newspaper |
author |
Diego Cantoni Jeremy S Rossman |
author_facet |
Diego Cantoni Jeremy S Rossman |
author_sort |
Diego Cantoni |
title |
Ebolaviruses: New roles for old proteins. |
title_short |
Ebolaviruses: New roles for old proteins. |
title_full |
Ebolaviruses: New roles for old proteins. |
title_fullStr |
Ebolaviruses: New roles for old proteins. |
title_full_unstemmed |
Ebolaviruses: New roles for old proteins. |
title_sort |
ebolaviruses: new roles for old proteins. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0006349 https://doaj.org/article/b4662f4464cb4852b25a96bf0b13aad0 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 5, p e0006349 (2018) |
op_relation |
http://europepmc.org/articles/PMC5933699?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006349 https://doaj.org/article/b4662f4464cb4852b25a96bf0b13aad0 |
op_doi |
https://doi.org/10.1371/journal.pntd.0006349 |
container_title |
PLOS Neglected Tropical Diseases |
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12 |
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5 |
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e0006349 |
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1766335955274301440 |