Is it need a criterion LDL cholesterol in definition of metabolic syndrome?

• Main Authors: Yu. P. Nikitin, G. I. Simonova, K. K. Sozonova, O. V. Tatarinova
• Format: Article in Journal/Newspaper
• Language: Russian
• Published: Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics 2014
• Subjects: metabolic syndrome; blood lipids; hyper-ldl-cholesterol; Diseases of the blood and blood-forming organs; RC633-647.5; Diseases of the circulatory (Cardiovascular) system; RC666-701; Yakutia
• Online Access: https://doaj.org/article/b3f100ffb4ac4912b1993664d71af0b7

The average content of LDL cholesterol obtained 138.8 ± 39.3 mg/dl, in natives, but non-natives have obtained similar values: 137.7 ± 38.5 and 140.8 ± 40.0 (Рn-nn = 0.56) in the general population sample of olders (n = 485 pers.). Average values of LDL cholesterol content in group without metabolic syndrome (MS–) obtained 126.1 ± 42.1 mg/dl, in MS (+) group – 150.7 ± 32.4 mg/dl (р = 0.0001) by RSSC 2009. Determine the frequency of elevated levels of LDL cholesterol (≥ 115 mg/dl) is 72.4 % in the general population, without significant difference between natives and non-natives. In MS (+) and MS (–) groups, the results of the frequency of hyper-LDL cholesterol obtained close in five definitions of MS. The differences in figures are not large and statistically significant (p > 0.1). And in only one case (by RSSC analysis) differences in the values of hyper-LDL between MS (+) and MS (–) groups received significant. Conclusion: High level of LDL cholesterol in all MS definitions has no significant differences in the frequency in MS (+) and MS (–) groups of elderly urban population of Yakutia, and also in comparison with population values of hyper-LDL. It allows to recognize that there is no reason to recommend in medical practice the use of the criterion LDL cholesterol in MS diagnosis.