Changing malaria intervention coverage, transmission and hospitalization in Kenya
Abstract Background Reports of declining incidence of malaria disease burden across several countries in Africa suggest that the epidemiology of malaria across the continent is in transition. Whether this transition is directly related to the scaling of intervention coverage remains a moot point. Me...
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ftdoajarticles:oai:doaj.org/article:b3b6d5b4684242dfbbc9c23b8be484d6 2023-05-15T15:14:37+02:00 Changing malaria intervention coverage, transmission and hospitalization in Kenya Noor Abdisalan M Alegana Victor A Okiro Emelda A Snow Robert W 2010-10-01T00:00:00Z https://doi.org/10.1186/1475-2875-9-285 https://doaj.org/article/b3b6d5b4684242dfbbc9c23b8be484d6 EN eng BMC http://www.malariajournal.com/content/9/1/285 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-9-285 1475-2875 https://doaj.org/article/b3b6d5b4684242dfbbc9c23b8be484d6 Malaria Journal, Vol 9, Iss 1, p 285 (2010) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2010 ftdoajarticles https://doi.org/10.1186/1475-2875-9-285 2022-12-30T21:52:35Z Abstract Background Reports of declining incidence of malaria disease burden across several countries in Africa suggest that the epidemiology of malaria across the continent is in transition. Whether this transition is directly related to the scaling of intervention coverage remains a moot point. Methods Paediatric admission data from eight Kenyan hospitals and their catchments have been assembled across two three-year time periods: September 2003 to August 2006 (pre-scaled intervention) and September 2006 to August 2009 (post-scaled intervention). Interrupted time series (ITS) models were developed adjusting for variations in rainfall and hospital use by surrounding communities to show changes in malaria hospitalization over the two periods. The temporal changes in factors that might explain changes in disease incidence were examined sequentially for each hospital setting, compared between hospital settings and ranked according to plausible explanatory factors. Results In six out of eight sites there was a decline in Malaria admission rates with declines between 18% and 69%. At two sites malaria admissions rates increased by 55% and 35%. Results from the ITS models indicate that before scaled intervention in September 2006, there was a significant month-to-month decline in the mean malaria admission rates at four hospitals (trend P < 0.05). At the point of scaled intervention, the estimated mean admission rates for malaria was significantly less at four sites compared to the pre-scaled period baseline. Following scaled intervention there was a significant change in the month-to-month trend in the mean malaria admission rates in some but not all of the sites. Plausibility assessment of possible drivers of change pre- versus post-scaled intervention showed inconsistent patterns however, allowing for the increase in rainfall in the second period, there is a suggestion that starting transmission intensity and the scale of change in ITN coverage might explain some but not all of the variation in effect size. At ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Moot ENVELOPE(-64.083,-64.083,-65.200,-65.200) Moot Point ENVELOPE(-64.100,-64.100,-65.200,-65.200) Malaria Journal 9 1 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Noor Abdisalan M Alegana Victor A Okiro Emelda A Snow Robert W Changing malaria intervention coverage, transmission and hospitalization in Kenya |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Reports of declining incidence of malaria disease burden across several countries in Africa suggest that the epidemiology of malaria across the continent is in transition. Whether this transition is directly related to the scaling of intervention coverage remains a moot point. Methods Paediatric admission data from eight Kenyan hospitals and their catchments have been assembled across two three-year time periods: September 2003 to August 2006 (pre-scaled intervention) and September 2006 to August 2009 (post-scaled intervention). Interrupted time series (ITS) models were developed adjusting for variations in rainfall and hospital use by surrounding communities to show changes in malaria hospitalization over the two periods. The temporal changes in factors that might explain changes in disease incidence were examined sequentially for each hospital setting, compared between hospital settings and ranked according to plausible explanatory factors. Results In six out of eight sites there was a decline in Malaria admission rates with declines between 18% and 69%. At two sites malaria admissions rates increased by 55% and 35%. Results from the ITS models indicate that before scaled intervention in September 2006, there was a significant month-to-month decline in the mean malaria admission rates at four hospitals (trend P < 0.05). At the point of scaled intervention, the estimated mean admission rates for malaria was significantly less at four sites compared to the pre-scaled period baseline. Following scaled intervention there was a significant change in the month-to-month trend in the mean malaria admission rates in some but not all of the sites. Plausibility assessment of possible drivers of change pre- versus post-scaled intervention showed inconsistent patterns however, allowing for the increase in rainfall in the second period, there is a suggestion that starting transmission intensity and the scale of change in ITN coverage might explain some but not all of the variation in effect size. At ... |
format |
Article in Journal/Newspaper |
author |
Noor Abdisalan M Alegana Victor A Okiro Emelda A Snow Robert W |
author_facet |
Noor Abdisalan M Alegana Victor A Okiro Emelda A Snow Robert W |
author_sort |
Noor Abdisalan M |
title |
Changing malaria intervention coverage, transmission and hospitalization in Kenya |
title_short |
Changing malaria intervention coverage, transmission and hospitalization in Kenya |
title_full |
Changing malaria intervention coverage, transmission and hospitalization in Kenya |
title_fullStr |
Changing malaria intervention coverage, transmission and hospitalization in Kenya |
title_full_unstemmed |
Changing malaria intervention coverage, transmission and hospitalization in Kenya |
title_sort |
changing malaria intervention coverage, transmission and hospitalization in kenya |
publisher |
BMC |
publishDate |
2010 |
url |
https://doi.org/10.1186/1475-2875-9-285 https://doaj.org/article/b3b6d5b4684242dfbbc9c23b8be484d6 |
long_lat |
ENVELOPE(-64.083,-64.083,-65.200,-65.200) ENVELOPE(-64.100,-64.100,-65.200,-65.200) |
geographic |
Arctic Moot Moot Point |
geographic_facet |
Arctic Moot Moot Point |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 9, Iss 1, p 285 (2010) |
op_relation |
http://www.malariajournal.com/content/9/1/285 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-9-285 1475-2875 https://doaj.org/article/b3b6d5b4684242dfbbc9c23b8be484d6 |
op_doi |
https://doi.org/10.1186/1475-2875-9-285 |
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Malaria Journal |
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9 |
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