Serologic and molecular evidence for circulation of Crimean-Congo hemorrhagic fever virus in ticks and cattle in Zambia.
Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne zoonosis with a high case fatality rate in humans. Although the disease is widely found in Africa, Europe, and Asia, the distribution and genetic diversity of CCHF virus (CCHFV) are poorly understood in African countries. To assess the risks of...
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ftdoajarticles:oai:doaj.org/article:b39ae197ea174e0d8f5ab4530e276594 2023-05-15T15:04:19+02:00 Serologic and molecular evidence for circulation of Crimean-Congo hemorrhagic fever virus in ticks and cattle in Zambia. Masahiro Kajihara Martin Simuunza Ngonda Saasa George Dautu Akina Mori-Kajihara Yongjin Qiu Ryo Nakao Yoshiki Eto Hayato Furumoto Bernard M Hang'ombe Yasuko Orba Hirofumi Sawa Edgar Simulundu Shuetsu Fukushi Shigeru Morikawa Masayuki Saijo Jiro Arikawa Swithine Kabilika Mwaka Monze Victor Mukonka Aaron Mweene Ayato Takada Kumiko Yoshimatsu 2021-06-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009452 https://doaj.org/article/b39ae197ea174e0d8f5ab4530e276594 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009452 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009452 https://doaj.org/article/b39ae197ea174e0d8f5ab4530e276594 PLoS Neglected Tropical Diseases, Vol 15, Iss 6, p e0009452 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009452 2022-12-31T11:13:25Z Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne zoonosis with a high case fatality rate in humans. Although the disease is widely found in Africa, Europe, and Asia, the distribution and genetic diversity of CCHF virus (CCHFV) are poorly understood in African countries. To assess the risks of CCHF in Zambia, where CCHF has never been reported, epidemiologic studies in cattle and ticks were conducted. Through an indirect immunofluorescence assay, CCHFV nucleoprotein-specific serum IgG was detected in 8.4% (88/1,047) of cattle. Among 290 Hyalomma ticks, the principal vector of CCHFV, the viral genome was detected in 11 ticks. Phylogenetic analyses of the CCHFV S and M genome segments revealed that one of the detected viruses was a genetic reassortant between African and Asian strains. This study provides compelling evidence for the presence of CCHFV in Zambia and its transmission to vertebrate hosts. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 6 e0009452 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Masahiro Kajihara Martin Simuunza Ngonda Saasa George Dautu Akina Mori-Kajihara Yongjin Qiu Ryo Nakao Yoshiki Eto Hayato Furumoto Bernard M Hang'ombe Yasuko Orba Hirofumi Sawa Edgar Simulundu Shuetsu Fukushi Shigeru Morikawa Masayuki Saijo Jiro Arikawa Swithine Kabilika Mwaka Monze Victor Mukonka Aaron Mweene Ayato Takada Kumiko Yoshimatsu Serologic and molecular evidence for circulation of Crimean-Congo hemorrhagic fever virus in ticks and cattle in Zambia. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne zoonosis with a high case fatality rate in humans. Although the disease is widely found in Africa, Europe, and Asia, the distribution and genetic diversity of CCHF virus (CCHFV) are poorly understood in African countries. To assess the risks of CCHF in Zambia, where CCHF has never been reported, epidemiologic studies in cattle and ticks were conducted. Through an indirect immunofluorescence assay, CCHFV nucleoprotein-specific serum IgG was detected in 8.4% (88/1,047) of cattle. Among 290 Hyalomma ticks, the principal vector of CCHFV, the viral genome was detected in 11 ticks. Phylogenetic analyses of the CCHFV S and M genome segments revealed that one of the detected viruses was a genetic reassortant between African and Asian strains. This study provides compelling evidence for the presence of CCHFV in Zambia and its transmission to vertebrate hosts. |
format |
Article in Journal/Newspaper |
author |
Masahiro Kajihara Martin Simuunza Ngonda Saasa George Dautu Akina Mori-Kajihara Yongjin Qiu Ryo Nakao Yoshiki Eto Hayato Furumoto Bernard M Hang'ombe Yasuko Orba Hirofumi Sawa Edgar Simulundu Shuetsu Fukushi Shigeru Morikawa Masayuki Saijo Jiro Arikawa Swithine Kabilika Mwaka Monze Victor Mukonka Aaron Mweene Ayato Takada Kumiko Yoshimatsu |
author_facet |
Masahiro Kajihara Martin Simuunza Ngonda Saasa George Dautu Akina Mori-Kajihara Yongjin Qiu Ryo Nakao Yoshiki Eto Hayato Furumoto Bernard M Hang'ombe Yasuko Orba Hirofumi Sawa Edgar Simulundu Shuetsu Fukushi Shigeru Morikawa Masayuki Saijo Jiro Arikawa Swithine Kabilika Mwaka Monze Victor Mukonka Aaron Mweene Ayato Takada Kumiko Yoshimatsu |
author_sort |
Masahiro Kajihara |
title |
Serologic and molecular evidence for circulation of Crimean-Congo hemorrhagic fever virus in ticks and cattle in Zambia. |
title_short |
Serologic and molecular evidence for circulation of Crimean-Congo hemorrhagic fever virus in ticks and cattle in Zambia. |
title_full |
Serologic and molecular evidence for circulation of Crimean-Congo hemorrhagic fever virus in ticks and cattle in Zambia. |
title_fullStr |
Serologic and molecular evidence for circulation of Crimean-Congo hemorrhagic fever virus in ticks and cattle in Zambia. |
title_full_unstemmed |
Serologic and molecular evidence for circulation of Crimean-Congo hemorrhagic fever virus in ticks and cattle in Zambia. |
title_sort |
serologic and molecular evidence for circulation of crimean-congo hemorrhagic fever virus in ticks and cattle in zambia. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009452 https://doaj.org/article/b39ae197ea174e0d8f5ab4530e276594 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 6, p e0009452 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009452 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009452 https://doaj.org/article/b39ae197ea174e0d8f5ab4530e276594 |
op_doi |
https://doi.org/10.1371/journal.pntd.0009452 |
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PLOS Neglected Tropical Diseases |
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15 |
container_issue |
6 |
container_start_page |
e0009452 |
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1766336113411096576 |