Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice
The aim of the present study was to investigate the presence of Trypanosoma cruzi in the heart, liver, lung, and kidneys, using hemoculture and PCR analysis, of mice infected with different parasite strains during the acute and chronic phases of infection. Parasitemia curves revealed strain-specific...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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Online Access: | https://doi.org/10.1590/S1678-91992012000100005 https://doaj.org/article/b37513f0285941c6b8692feabc831e4c |
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ftdoajarticles:oai:doaj.org/article:b37513f0285941c6b8692feabc831e4c 2023-05-15T15:05:37+02:00 Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice LRC Oliveira MCM Picka VC Nicolete SA Calvi J Marcondes-Machado 2012-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992012000100005 https://doaj.org/article/b37513f0285941c6b8692feabc831e4c EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000100005 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992012000100005 1678-9199 https://doaj.org/article/b37513f0285941c6b8692feabc831e4c Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 18, Iss 1, Pp 34-43 (2012) Trypanosoma cruzi PCR hemoculture organs distribution Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2012 ftdoajarticles https://doi.org/10.1590/S1678-91992012000100005 2022-12-31T07:28:38Z The aim of the present study was to investigate the presence of Trypanosoma cruzi in the heart, liver, lung, and kidneys, using hemoculture and PCR analysis, of mice infected with different parasite strains during the acute and chronic phases of infection. Parasitemia curves revealed strain-specific biological behaviors. For the Y and JLP strains, the acute phase of infection started at days six and ten post-infection, parasitemia peaked at days seven and 15 post-infection, the chronic phase started at days nine and 28 post-infection, and animals started dying at days 19 and 120 post-infection, respectively. When the two strains were compared, the JLP strain exhibited reduced and slower replication rates associated with a delayed peak of parasitism and reduced parasite burdens. However, parasites were detected in all studied organs using PCR analysis. The capacity of both strains to infect different organs likely influences disease pathogenesis. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic The ''Y'' ENVELOPE(-112.453,-112.453,57.591,57.591) Journal of Venomous Animals and Toxins including Tropical Diseases 18 1 34 43 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Trypanosoma cruzi PCR hemoculture organs distribution Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
Trypanosoma cruzi PCR hemoculture organs distribution Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 LRC Oliveira MCM Picka VC Nicolete SA Calvi J Marcondes-Machado Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice |
topic_facet |
Trypanosoma cruzi PCR hemoculture organs distribution Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
The aim of the present study was to investigate the presence of Trypanosoma cruzi in the heart, liver, lung, and kidneys, using hemoculture and PCR analysis, of mice infected with different parasite strains during the acute and chronic phases of infection. Parasitemia curves revealed strain-specific biological behaviors. For the Y and JLP strains, the acute phase of infection started at days six and ten post-infection, parasitemia peaked at days seven and 15 post-infection, the chronic phase started at days nine and 28 post-infection, and animals started dying at days 19 and 120 post-infection, respectively. When the two strains were compared, the JLP strain exhibited reduced and slower replication rates associated with a delayed peak of parasitism and reduced parasite burdens. However, parasites were detected in all studied organs using PCR analysis. The capacity of both strains to infect different organs likely influences disease pathogenesis. |
format |
Article in Journal/Newspaper |
author |
LRC Oliveira MCM Picka VC Nicolete SA Calvi J Marcondes-Machado |
author_facet |
LRC Oliveira MCM Picka VC Nicolete SA Calvi J Marcondes-Machado |
author_sort |
LRC Oliveira |
title |
Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice |
title_short |
Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice |
title_full |
Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice |
title_fullStr |
Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice |
title_full_unstemmed |
Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice |
title_sort |
organ tropism during the acute and chronic phases of trypanosoma cruzi infection in balb/c mice |
publisher |
SciELO |
publishDate |
2012 |
url |
https://doi.org/10.1590/S1678-91992012000100005 https://doaj.org/article/b37513f0285941c6b8692feabc831e4c |
long_lat |
ENVELOPE(-112.453,-112.453,57.591,57.591) |
geographic |
Arctic The ''Y'' |
geographic_facet |
Arctic The ''Y'' |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 18, Iss 1, Pp 34-43 (2012) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000100005 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992012000100005 1678-9199 https://doaj.org/article/b37513f0285941c6b8692feabc831e4c |
op_doi |
https://doi.org/10.1590/S1678-91992012000100005 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
18 |
container_issue |
1 |
container_start_page |
34 |
op_container_end_page |
43 |
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1766337277056778240 |