Infectious etiology and indicators of malabsorption or intestinal injury in childhood diarrhea
Introduction. The multifactorial etiology of gastroenteritis emphasizes the need for different laboratory methods to identify or exclude infectious agents and evaluate the severity of diarrheal disease. Objective. To diagnose the infectious etiology in diarrheic children and to evaluate some fecal m...
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Instituto Nacional de Salud
2024
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ftdoajarticles:oai:doaj.org/article:b369d92cf90a4f7e8cec233b141b6e35 2024-09-09T19:26:40+00:00 Infectious etiology and indicators of malabsorption or intestinal injury in childhood diarrhea Adson Santos Martins Samara Alves Santos Cláudia Alves da Silva Lisboa Tânia Fraga Barros Tereza Cristina Medrado Ribeiro Hugo da Costa-Ribeiro Ângela Peixoto de Mattos Patrícia Silva de Almeida Mendes Carlos Maurício Cardeal Mendes Edna Lúcia Souza Ana Lúcia Moreno Amor Neci Matos Soares Márcia Cristina Aquino Teixeira 2024-03-01T00:00:00Z https://doi.org/10.7705/biomedica.6913 https://doaj.org/article/b369d92cf90a4f7e8cec233b141b6e35 EN ES eng spa Instituto Nacional de Salud https://revistabiomedica.org/index.php/biomedica/article/view/6913 https://doaj.org/toc/0120-4157 https://doaj.org/toc/2590-7379 0120-4157 2590-7379 doi:10.7705/biomedica.6913 https://doaj.org/article/b369d92cf90a4f7e8cec233b141b6e35 Biomédica: revista del Instituto Nacional de Salud, Vol 44, Iss 1, Pp 80-91 (2024) diarrheal disease infectious children enterobacteria enterovirus entamoeba histolytica giardia duodenalis blastocystis steatocrit Medicine R Arctic medicine. Tropical medicine RC955-962 article 2024 ftdoajarticles https://doi.org/10.7705/biomedica.6913 2024-08-05T17:49:33Z Introduction. The multifactorial etiology of gastroenteritis emphasizes the need for different laboratory methods to identify or exclude infectious agents and evaluate the severity of diarrheal disease. Objective. To diagnose the infectious etiology in diarrheic children and to evaluate some fecal markers associated with intestinal integrity. Materials and methods. The study group comprised 45 children with diarrheal disease, tested for enteropathogens and malabsorption markers, and 76 children whose feces were used for fat evaluation by the traditional and acid steatocrit tests. Results. We observed acute diarrhea in 80% of the children and persistent diarrhea in 20%. Of the diarrheic individuals analyzed, 40% were positive for enteropathogens, with rotavirus (13.3%) and Giardia duodenalis (11.1%) the most frequently diagnosed. Among the infected patients, occult blood was more evident in those carrying pathogenic bacteria (40%) and enteroviruses (40%), while steatorrhea was observed in infections by the protozoa G. duodenalis (35.7%). Children with diarrhea excreted significantly more lipids in feces than non-diarrheic children, as determined by the traditional (p<0.0003) and acid steatocrit (p<0.0001) methods. Moreover, the acid steatocrit method detected 16.7% more fecal fat than the traditional method. Conclusions. Childhood diarrhea can lead to increasingly severe nutrient deficiencies. Steatorrhea is the hallmark of malabsorption, and a stool test, such as the acid steatocrit, can be routinely used as a laboratory tool for the semi-quantitative evaluation of fat malabsorption in diarrheic children. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Biomédica 44 1 80 91 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English Spanish |
topic |
diarrheal disease infectious children enterobacteria enterovirus entamoeba histolytica giardia duodenalis blastocystis steatocrit Medicine R Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
diarrheal disease infectious children enterobacteria enterovirus entamoeba histolytica giardia duodenalis blastocystis steatocrit Medicine R Arctic medicine. Tropical medicine RC955-962 Adson Santos Martins Samara Alves Santos Cláudia Alves da Silva Lisboa Tânia Fraga Barros Tereza Cristina Medrado Ribeiro Hugo da Costa-Ribeiro Ângela Peixoto de Mattos Patrícia Silva de Almeida Mendes Carlos Maurício Cardeal Mendes Edna Lúcia Souza Ana Lúcia Moreno Amor Neci Matos Soares Márcia Cristina Aquino Teixeira Infectious etiology and indicators of malabsorption or intestinal injury in childhood diarrhea |
topic_facet |
diarrheal disease infectious children enterobacteria enterovirus entamoeba histolytica giardia duodenalis blastocystis steatocrit Medicine R Arctic medicine. Tropical medicine RC955-962 |
description |
Introduction. The multifactorial etiology of gastroenteritis emphasizes the need for different laboratory methods to identify or exclude infectious agents and evaluate the severity of diarrheal disease. Objective. To diagnose the infectious etiology in diarrheic children and to evaluate some fecal markers associated with intestinal integrity. Materials and methods. The study group comprised 45 children with diarrheal disease, tested for enteropathogens and malabsorption markers, and 76 children whose feces were used for fat evaluation by the traditional and acid steatocrit tests. Results. We observed acute diarrhea in 80% of the children and persistent diarrhea in 20%. Of the diarrheic individuals analyzed, 40% were positive for enteropathogens, with rotavirus (13.3%) and Giardia duodenalis (11.1%) the most frequently diagnosed. Among the infected patients, occult blood was more evident in those carrying pathogenic bacteria (40%) and enteroviruses (40%), while steatorrhea was observed in infections by the protozoa G. duodenalis (35.7%). Children with diarrhea excreted significantly more lipids in feces than non-diarrheic children, as determined by the traditional (p<0.0003) and acid steatocrit (p<0.0001) methods. Moreover, the acid steatocrit method detected 16.7% more fecal fat than the traditional method. Conclusions. Childhood diarrhea can lead to increasingly severe nutrient deficiencies. Steatorrhea is the hallmark of malabsorption, and a stool test, such as the acid steatocrit, can be routinely used as a laboratory tool for the semi-quantitative evaluation of fat malabsorption in diarrheic children. |
format |
Article in Journal/Newspaper |
author |
Adson Santos Martins Samara Alves Santos Cláudia Alves da Silva Lisboa Tânia Fraga Barros Tereza Cristina Medrado Ribeiro Hugo da Costa-Ribeiro Ângela Peixoto de Mattos Patrícia Silva de Almeida Mendes Carlos Maurício Cardeal Mendes Edna Lúcia Souza Ana Lúcia Moreno Amor Neci Matos Soares Márcia Cristina Aquino Teixeira |
author_facet |
Adson Santos Martins Samara Alves Santos Cláudia Alves da Silva Lisboa Tânia Fraga Barros Tereza Cristina Medrado Ribeiro Hugo da Costa-Ribeiro Ângela Peixoto de Mattos Patrícia Silva de Almeida Mendes Carlos Maurício Cardeal Mendes Edna Lúcia Souza Ana Lúcia Moreno Amor Neci Matos Soares Márcia Cristina Aquino Teixeira |
author_sort |
Adson Santos Martins |
title |
Infectious etiology and indicators of malabsorption or intestinal injury in childhood diarrhea |
title_short |
Infectious etiology and indicators of malabsorption or intestinal injury in childhood diarrhea |
title_full |
Infectious etiology and indicators of malabsorption or intestinal injury in childhood diarrhea |
title_fullStr |
Infectious etiology and indicators of malabsorption or intestinal injury in childhood diarrhea |
title_full_unstemmed |
Infectious etiology and indicators of malabsorption or intestinal injury in childhood diarrhea |
title_sort |
infectious etiology and indicators of malabsorption or intestinal injury in childhood diarrhea |
publisher |
Instituto Nacional de Salud |
publishDate |
2024 |
url |
https://doi.org/10.7705/biomedica.6913 https://doaj.org/article/b369d92cf90a4f7e8cec233b141b6e35 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Biomédica: revista del Instituto Nacional de Salud, Vol 44, Iss 1, Pp 80-91 (2024) |
op_relation |
https://revistabiomedica.org/index.php/biomedica/article/view/6913 https://doaj.org/toc/0120-4157 https://doaj.org/toc/2590-7379 0120-4157 2590-7379 doi:10.7705/biomedica.6913 https://doaj.org/article/b369d92cf90a4f7e8cec233b141b6e35 |
op_doi |
https://doi.org/10.7705/biomedica.6913 |
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Biomédica |
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44 |
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80 |
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91 |
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