Ameliorative effect of Morus alba leaves extract against developmental retinopathy in pups of diabetic and aluminum intoxicated pregnant albino rats
Objective: To investigate the possible ameliorative effect of crude water extract of Morus alba (M. alba) leaves on retinopathy of rat pups maternally subjected to diabetes and/or Al intoxication. Methods: Both control and experimental groups were subjected to certain integrated approaches, namely,...
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Wolters Kluwer Medknow Publications
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ftdoajarticles:oai:doaj.org/article:b34e3072c18d4e07b866244e7ae94afe 2023-05-15T15:07:04+02:00 Ameliorative effect of Morus alba leaves extract against developmental retinopathy in pups of diabetic and aluminum intoxicated pregnant albino rats Hassan El-Sayyed Gamal Badawy Sobhy Hassab Elnabi Ibrahim El-Elaimy Eman Al Shehari 2015-04-01T00:00:00Z https://doi.org/10.1016/S2221-1691(15)30349-X https://doaj.org/article/b34e3072c18d4e07b866244e7ae94afe EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S222116911530349X https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/S2221-1691(15)30349-X https://doaj.org/article/b34e3072c18d4e07b866244e7ae94afe Asian Pacific Journal of Tropical Biomedicine, Vol 5, Iss 4, Pp 300-309 (2015) Morus alba Retinopathy Aluminum Diabetes TEM Comet assay Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2015 ftdoajarticles https://doi.org/10.1016/S2221-1691(15)30349-X 2022-12-31T09:47:31Z Objective: To investigate the possible ameliorative effect of crude water extract of Morus alba (M. alba) leaves on retinopathy of rat pups maternally subjected to diabetes and/or Al intoxication. Methods: Both control and experimental groups were subjected to certain integrated approaches, namely, biochemical assessments, light microscopic investigation, transmission electron microscopic investigation, single cell gel electrophoresis (comet assay) and determination of DNA fragmentation. Results: The retina of pups of diabetic and/or Al-intoxicated mothers exhibited abnormal alterations in retinal cell layers including retinal pigmented epithelium, photoreceptor inner segment and ganglion cells. Increased incidence of DNA fragmentation and apoptosis were evident in pups of diabetic and/or Al-intoxicated mothers. However, retina of pups maternally received M. alba extract plus diabetes or Al-intoxicated alone or in combination showed marked amelioration. Less degree of ameliorations was seen in retina of pups maternally subjected to combined treatment. Furthermore, application of crude water extract of M. alba resulted in amelioration of the alterations of maternal serum glucose as well as Al concentration. Conclusions: Based on the results of the present study, M. alba extract is effective against experimentally diabetic and Al-induced developmental retinopathy. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 5 4 300 309 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
Morus alba Retinopathy Aluminum Diabetes TEM Comet assay Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
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Morus alba Retinopathy Aluminum Diabetes TEM Comet assay Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Hassan El-Sayyed Gamal Badawy Sobhy Hassab Elnabi Ibrahim El-Elaimy Eman Al Shehari Ameliorative effect of Morus alba leaves extract against developmental retinopathy in pups of diabetic and aluminum intoxicated pregnant albino rats |
topic_facet |
Morus alba Retinopathy Aluminum Diabetes TEM Comet assay Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To investigate the possible ameliorative effect of crude water extract of Morus alba (M. alba) leaves on retinopathy of rat pups maternally subjected to diabetes and/or Al intoxication. Methods: Both control and experimental groups were subjected to certain integrated approaches, namely, biochemical assessments, light microscopic investigation, transmission electron microscopic investigation, single cell gel electrophoresis (comet assay) and determination of DNA fragmentation. Results: The retina of pups of diabetic and/or Al-intoxicated mothers exhibited abnormal alterations in retinal cell layers including retinal pigmented epithelium, photoreceptor inner segment and ganglion cells. Increased incidence of DNA fragmentation and apoptosis were evident in pups of diabetic and/or Al-intoxicated mothers. However, retina of pups maternally received M. alba extract plus diabetes or Al-intoxicated alone or in combination showed marked amelioration. Less degree of ameliorations was seen in retina of pups maternally subjected to combined treatment. Furthermore, application of crude water extract of M. alba resulted in amelioration of the alterations of maternal serum glucose as well as Al concentration. Conclusions: Based on the results of the present study, M. alba extract is effective against experimentally diabetic and Al-induced developmental retinopathy. |
format |
Article in Journal/Newspaper |
author |
Hassan El-Sayyed Gamal Badawy Sobhy Hassab Elnabi Ibrahim El-Elaimy Eman Al Shehari |
author_facet |
Hassan El-Sayyed Gamal Badawy Sobhy Hassab Elnabi Ibrahim El-Elaimy Eman Al Shehari |
author_sort |
Hassan El-Sayyed |
title |
Ameliorative effect of Morus alba leaves extract against developmental retinopathy in pups of diabetic and aluminum intoxicated pregnant albino rats |
title_short |
Ameliorative effect of Morus alba leaves extract against developmental retinopathy in pups of diabetic and aluminum intoxicated pregnant albino rats |
title_full |
Ameliorative effect of Morus alba leaves extract against developmental retinopathy in pups of diabetic and aluminum intoxicated pregnant albino rats |
title_fullStr |
Ameliorative effect of Morus alba leaves extract against developmental retinopathy in pups of diabetic and aluminum intoxicated pregnant albino rats |
title_full_unstemmed |
Ameliorative effect of Morus alba leaves extract against developmental retinopathy in pups of diabetic and aluminum intoxicated pregnant albino rats |
title_sort |
ameliorative effect of morus alba leaves extract against developmental retinopathy in pups of diabetic and aluminum intoxicated pregnant albino rats |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2015 |
url |
https://doi.org/10.1016/S2221-1691(15)30349-X https://doaj.org/article/b34e3072c18d4e07b866244e7ae94afe |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 5, Iss 4, Pp 300-309 (2015) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S222116911530349X https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/S2221-1691(15)30349-X https://doaj.org/article/b34e3072c18d4e07b866244e7ae94afe |
op_doi |
https://doi.org/10.1016/S2221-1691(15)30349-X |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
5 |
container_issue |
4 |
container_start_page |
300 |
op_container_end_page |
309 |
_version_ |
1766338633523003392 |