Evidence of transovarial transmission of Chikungunya and Dengue viruses in field-caught mosquitoes in Kenya.
Arboviruses are among the most important emerging pathogens due to their increasing public health impact. In Kenya, continued population growth and associated urbanization are conducive to vector spread in both urban and rural environments, yet mechanisms of viral amplification in vector populations...
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ftdoajarticles:oai:doaj.org/article:b3266bf482014fd8860b562026735425 2023-05-15T15:07:36+02:00 Evidence of transovarial transmission of Chikungunya and Dengue viruses in field-caught mosquitoes in Kenya. Claire J Heath Elysse N Grossi-Soyster Bryson A Ndenga Francis M Mutuku Malaya K Sahoo Harun N Ngugi Joel O Mbakaya Peter Siema Uriel Kitron Nayer Zahiri Jimmy Hortion Jesse J Waggoner Charles H King Benjamin A Pinsky A Desiree LaBeaud 2020-06-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008362 https://doaj.org/article/b3266bf482014fd8860b562026735425 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008362 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008362 https://doaj.org/article/b3266bf482014fd8860b562026735425 PLoS Neglected Tropical Diseases, Vol 14, Iss 6, p e0008362 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008362 2022-12-31T09:15:14Z Arboviruses are among the most important emerging pathogens due to their increasing public health impact. In Kenya, continued population growth and associated urbanization are conducive to vector spread in both urban and rural environments, yet mechanisms of viral amplification in vector populations is often overlooked when assessing risks for outbreaks. Thus, the characterization of local arbovirus circulation in mosquito populations is imperative to better inform risk assessments and vector control practices. Aedes species mosquitoes were captured at varying stages of their life cycle during different seasons between January 2014 and May 2016 at four distinct sites in Kenya, and tested for chikungunya (CHIKV), dengue (DENV) and Zika (ZIKV) viruses by RT-PCR. CHIKV was detected in 45 (5.9%) and DENV in 3 (0.4%) mosquito pools. No ZIKV was detected. Significant regional variation in prevalence was observed, with greater frequency of CHIKV on the coast. DENV was detected exclusively on the coast. Both viruses were detected in immature mosquitoes of both sexes, providing evidence of transovarial transmission of these arboviruses in local mosquitoes. This phenomenon may be driving underlying viral maintenance that may largely contribute to periodic re-emergence among humans in Kenya. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 14 6 e0008362 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Claire J Heath Elysse N Grossi-Soyster Bryson A Ndenga Francis M Mutuku Malaya K Sahoo Harun N Ngugi Joel O Mbakaya Peter Siema Uriel Kitron Nayer Zahiri Jimmy Hortion Jesse J Waggoner Charles H King Benjamin A Pinsky A Desiree LaBeaud Evidence of transovarial transmission of Chikungunya and Dengue viruses in field-caught mosquitoes in Kenya. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Arboviruses are among the most important emerging pathogens due to their increasing public health impact. In Kenya, continued population growth and associated urbanization are conducive to vector spread in both urban and rural environments, yet mechanisms of viral amplification in vector populations is often overlooked when assessing risks for outbreaks. Thus, the characterization of local arbovirus circulation in mosquito populations is imperative to better inform risk assessments and vector control practices. Aedes species mosquitoes were captured at varying stages of their life cycle during different seasons between January 2014 and May 2016 at four distinct sites in Kenya, and tested for chikungunya (CHIKV), dengue (DENV) and Zika (ZIKV) viruses by RT-PCR. CHIKV was detected in 45 (5.9%) and DENV in 3 (0.4%) mosquito pools. No ZIKV was detected. Significant regional variation in prevalence was observed, with greater frequency of CHIKV on the coast. DENV was detected exclusively on the coast. Both viruses were detected in immature mosquitoes of both sexes, providing evidence of transovarial transmission of these arboviruses in local mosquitoes. This phenomenon may be driving underlying viral maintenance that may largely contribute to periodic re-emergence among humans in Kenya. |
format |
Article in Journal/Newspaper |
author |
Claire J Heath Elysse N Grossi-Soyster Bryson A Ndenga Francis M Mutuku Malaya K Sahoo Harun N Ngugi Joel O Mbakaya Peter Siema Uriel Kitron Nayer Zahiri Jimmy Hortion Jesse J Waggoner Charles H King Benjamin A Pinsky A Desiree LaBeaud |
author_facet |
Claire J Heath Elysse N Grossi-Soyster Bryson A Ndenga Francis M Mutuku Malaya K Sahoo Harun N Ngugi Joel O Mbakaya Peter Siema Uriel Kitron Nayer Zahiri Jimmy Hortion Jesse J Waggoner Charles H King Benjamin A Pinsky A Desiree LaBeaud |
author_sort |
Claire J Heath |
title |
Evidence of transovarial transmission of Chikungunya and Dengue viruses in field-caught mosquitoes in Kenya. |
title_short |
Evidence of transovarial transmission of Chikungunya and Dengue viruses in field-caught mosquitoes in Kenya. |
title_full |
Evidence of transovarial transmission of Chikungunya and Dengue viruses in field-caught mosquitoes in Kenya. |
title_fullStr |
Evidence of transovarial transmission of Chikungunya and Dengue viruses in field-caught mosquitoes in Kenya. |
title_full_unstemmed |
Evidence of transovarial transmission of Chikungunya and Dengue viruses in field-caught mosquitoes in Kenya. |
title_sort |
evidence of transovarial transmission of chikungunya and dengue viruses in field-caught mosquitoes in kenya. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008362 https://doaj.org/article/b3266bf482014fd8860b562026735425 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 6, p e0008362 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008362 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008362 https://doaj.org/article/b3266bf482014fd8860b562026735425 |
op_doi |
https://doi.org/10.1371/journal.pntd.0008362 |
container_title |
PLOS Neglected Tropical Diseases |
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14 |
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6 |
container_start_page |
e0008362 |
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