Gene conversion transfers the GAF-A domain of phosphodiesterase TbrPDEB1 to one allele of TbrPDEB2 of Trypanosoma brucei.

• Published in: PLoS Neglected Tropical Diseases
• Main Authors: Stefan Kunz, Edith Luginbuehl, Thomas Seebeck
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2009
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Lister
• Online Access: https://doi.org/10.1371/journal.pntd.0000455; https://doaj.org/article/b31929ce38b14967883c3e6c3551649e

BACKGROUND: Chromosome 9 of Trypanosoma brucei contains two closely spaced, very similar open reading frames for cyclic nucleotide specific phosphodiesterases TbrPDEB1 and TbrPDEB2. They are separated by 2379 bp, and both code for phosphodiesterases with two GAF domains in their N-terminal moieties...