Prevalence and clinical significance of antiphospholipid antibodies among hospitalized COVID-19 patients
Objective: To describe the prevalence of antiphospholipid antibodies in coronavirus disease-19 (COVID-19) and to find potential associations between antiphospholipid antibody positivity and clinical outcomes. Methods: From September to November 2020, clinical and laboratory data were collected from...
Published in: | Asian Pacific Journal of Tropical Medicine |
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Wolters Kluwer Medknow Publications
2021
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Online Access: | https://doi.org/10.4103/1995-7645.321611 https://doaj.org/article/b2d1efea36f14d9daa4da98abd50863b |
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ftdoajarticles:oai:doaj.org/article:b2d1efea36f14d9daa4da98abd50863b 2023-05-15T15:15:57+02:00 Prevalence and clinical significance of antiphospholipid antibodies among hospitalized COVID-19 patients Cesarius Singgih Wahono Hani Susianti Tri Wahyudi Iman Dantara Perdana Aditya Rahman Mirza Zaka Pratama Indah Adhita Wulanda Khoirunisah Dwi Hartanti Elvira Sari Dewi Kusworini Handono 2021-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.321611 https://doaj.org/article/b2d1efea36f14d9daa4da98abd50863b EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2021;volume=14;issue=8;spage=350;epage=355;aulast=Wahono https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.321611 https://doaj.org/article/b2d1efea36f14d9daa4da98abd50863b Asian Pacific Journal of Tropical Medicine, Vol 14, Iss 8, Pp 350-355 (2021) antiphospholipid antibodies covid-19 covid-19 disease severity mortality Arctic medicine. Tropical medicine RC955-962 article 2021 ftdoajarticles https://doi.org/10.4103/1995-7645.321611 2022-12-31T00:29:21Z Objective: To describe the prevalence of antiphospholipid antibodies in coronavirus disease-19 (COVID-19) and to find potential associations between antiphospholipid antibody positivity and clinical outcomes. Methods: From September to November 2020, clinical and laboratory data were collected from 50 COVID-19 patients hospitalized at Saiful Anwar General Hospital in Malang, Indonesia. Antiphospholipid antibodies were measured by finding IgM anti-β2 glycoprotein, lupus anticoagulant, and IgM/IgG anticardiolipin. Clinical characteristics, thrombotic events, ICU admission, and mortality during hospitalization were recorded. Disease severity was defined by the Guidelines for the Prevention and Control of COVID-19, Indonesia. Results: Among 50 patients, 5 patients (10.0%) were positive for antiphospholipid antibodies: 4 patients (80.0%) had IgM anti-β2 glycoprotein and 1 patient had IgG anti-cardiolipin (20.0%) and IgM anti-cardiolipin (20.0%), none of lupus anticoagulant was detected. Antiphospholipid antibodies were associated with anosmia (OR 8.1; 95% CI 1.1-57.9; P=0.018), nausea and vomiting (OR 12.4; 95% CI 1.2-122.6; P=0.010), diarrhea (OR 9.8; 95% CI 1.3-70.9; P=0.010), cardiovascular disease (OR 1.4; 95% CI 1.0-1.9; P=0.001), chronic kidney disease (OR 12.0; 95% CI 1.6-90.1; P=0.05), acute coronary syndrome (OR 29.3; 95% CI 2.0-423.7; P=0.001), moderate (OR 0.11; 95% CI 0.01-1.10; P=0.031) and severe (OR 18.5; 95% CI 1.8-188.4; P=0.002) disease severity, and in-hospital mortality (OR 8.1; 95% CI 1.1-57.9; P=0.018). However, there is no correlation between the presence of antiphospholipid antibody and ICU admission. Conclusions: In summary, the prevalence of antiphospholipid antibodies in COVID-19 patients is low, mainly against IgM anticardiolipin, and is associated with an acute coronary syndrome, gastrointestinal manifestations, moderate and severe disease severity, and increased risk of mortality. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Medicine 14 8 350 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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antiphospholipid antibodies covid-19 covid-19 disease severity mortality Arctic medicine. Tropical medicine RC955-962 |
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antiphospholipid antibodies covid-19 covid-19 disease severity mortality Arctic medicine. Tropical medicine RC955-962 Cesarius Singgih Wahono Hani Susianti Tri Wahyudi Iman Dantara Perdana Aditya Rahman Mirza Zaka Pratama Indah Adhita Wulanda Khoirunisah Dwi Hartanti Elvira Sari Dewi Kusworini Handono Prevalence and clinical significance of antiphospholipid antibodies among hospitalized COVID-19 patients |
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antiphospholipid antibodies covid-19 covid-19 disease severity mortality Arctic medicine. Tropical medicine RC955-962 |
description |
Objective: To describe the prevalence of antiphospholipid antibodies in coronavirus disease-19 (COVID-19) and to find potential associations between antiphospholipid antibody positivity and clinical outcomes. Methods: From September to November 2020, clinical and laboratory data were collected from 50 COVID-19 patients hospitalized at Saiful Anwar General Hospital in Malang, Indonesia. Antiphospholipid antibodies were measured by finding IgM anti-β2 glycoprotein, lupus anticoagulant, and IgM/IgG anticardiolipin. Clinical characteristics, thrombotic events, ICU admission, and mortality during hospitalization were recorded. Disease severity was defined by the Guidelines for the Prevention and Control of COVID-19, Indonesia. Results: Among 50 patients, 5 patients (10.0%) were positive for antiphospholipid antibodies: 4 patients (80.0%) had IgM anti-β2 glycoprotein and 1 patient had IgG anti-cardiolipin (20.0%) and IgM anti-cardiolipin (20.0%), none of lupus anticoagulant was detected. Antiphospholipid antibodies were associated with anosmia (OR 8.1; 95% CI 1.1-57.9; P=0.018), nausea and vomiting (OR 12.4; 95% CI 1.2-122.6; P=0.010), diarrhea (OR 9.8; 95% CI 1.3-70.9; P=0.010), cardiovascular disease (OR 1.4; 95% CI 1.0-1.9; P=0.001), chronic kidney disease (OR 12.0; 95% CI 1.6-90.1; P=0.05), acute coronary syndrome (OR 29.3; 95% CI 2.0-423.7; P=0.001), moderate (OR 0.11; 95% CI 0.01-1.10; P=0.031) and severe (OR 18.5; 95% CI 1.8-188.4; P=0.002) disease severity, and in-hospital mortality (OR 8.1; 95% CI 1.1-57.9; P=0.018). However, there is no correlation between the presence of antiphospholipid antibody and ICU admission. Conclusions: In summary, the prevalence of antiphospholipid antibodies in COVID-19 patients is low, mainly against IgM anticardiolipin, and is associated with an acute coronary syndrome, gastrointestinal manifestations, moderate and severe disease severity, and increased risk of mortality. |
format |
Article in Journal/Newspaper |
author |
Cesarius Singgih Wahono Hani Susianti Tri Wahyudi Iman Dantara Perdana Aditya Rahman Mirza Zaka Pratama Indah Adhita Wulanda Khoirunisah Dwi Hartanti Elvira Sari Dewi Kusworini Handono |
author_facet |
Cesarius Singgih Wahono Hani Susianti Tri Wahyudi Iman Dantara Perdana Aditya Rahman Mirza Zaka Pratama Indah Adhita Wulanda Khoirunisah Dwi Hartanti Elvira Sari Dewi Kusworini Handono |
author_sort |
Cesarius Singgih Wahono |
title |
Prevalence and clinical significance of antiphospholipid antibodies among hospitalized COVID-19 patients |
title_short |
Prevalence and clinical significance of antiphospholipid antibodies among hospitalized COVID-19 patients |
title_full |
Prevalence and clinical significance of antiphospholipid antibodies among hospitalized COVID-19 patients |
title_fullStr |
Prevalence and clinical significance of antiphospholipid antibodies among hospitalized COVID-19 patients |
title_full_unstemmed |
Prevalence and clinical significance of antiphospholipid antibodies among hospitalized COVID-19 patients |
title_sort |
prevalence and clinical significance of antiphospholipid antibodies among hospitalized covid-19 patients |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2021 |
url |
https://doi.org/10.4103/1995-7645.321611 https://doaj.org/article/b2d1efea36f14d9daa4da98abd50863b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 14, Iss 8, Pp 350-355 (2021) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2021;volume=14;issue=8;spage=350;epage=355;aulast=Wahono https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.321611 https://doaj.org/article/b2d1efea36f14d9daa4da98abd50863b |
op_doi |
https://doi.org/10.4103/1995-7645.321611 |
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Asian Pacific Journal of Tropical Medicine |
container_volume |
14 |
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8 |
container_start_page |
350 |
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