Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil
In August 1983,85 inhabitants of the municipality of Humaitá, Amazonas State, Brazil were studied to determine the prevalence of antigens to HLA-A, -B, -C and DR. Thirty-eight were sick with malaria due to Plasmodium falciparum. All subjects were examined for splenomegaly, blood parasitaemia and ant...
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Sociedade Brasileira de Medicina Tropical (SBMT)
1987
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ftdoajarticles:oai:doaj.org/article:b2b5de65d5a94d2f9649e24a1e3d4c71 2023-05-15T15:18:06+02:00 Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil Domingos Alves Meira Jordão Pellegrino Júnior Jussara Marcondes-Machado Kimiyoski Tsuji Elinda Satie Matsuoka Elizete Haida Albert Boutros El Khoury 1987-09-01T00:00:00Z https://doaj.org/article/b2b5de65d5a94d2f9649e24a1e3d4c71 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821987000300005 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 0037-8682 1678-9849 https://doaj.org/article/b2b5de65d5a94d2f9649e24a1e3d4c71 Revista da Sociedade Brasileira de Medicina Tropical, Vol 20, Iss 3, Pp 153-158 (1987) Malária Plasmodium falciparum Prevalência de HLA Plasmodium falciparum malaria HLA frequency Arctic medicine. Tropical medicine RC955-962 article 1987 ftdoajarticles 2022-12-31T02:59:09Z In August 1983,85 inhabitants of the municipality of Humaitá, Amazonas State, Brazil were studied to determine the prevalence of antigens to HLA-A, -B, -C and DR. Thirty-eight were sick with malaria due to Plasmodium falciparum. All subjects were examined for splenomegaly, blood parasitaemia and antibodies to malaria. They constituted three groups: 1) 25 subjects native to the Amazon region who had never had malaria; 2) 38 Amazonian subjects who had malaria in the past or currently had an infection; 3) 22 patients with malaria who had acquired the infection in the Amazon Region but came from other regions of Brazil. Blood was taken from each person, the lymphocytes were separated and typed by the test of microlymphocytotoxicity. There was a high frequency of antigens that could not be identified in the groups studied which suggests the existence of a homozygote or phenotype not identified in the population. There was a high frequency of the phenotype Ag(W24) (44.7%) in group 2 when compared with group 1 (32%) or group 3 (9%). Also the individuals in group 2 showed an elevated frequency of antigen DR(4)80%) when compared with group 1 (36.6%) or group 3 (16.6%). These observations suggest the possibility of a genetic susceptibility to malaria among Amazonian residents and indicate a necessity for more extensive studies of the frequency of HLA antigens among inhabitants of this endemic malarial zone. Em agosto de 1983 foram observados 85 habitantes do Município de Humaitá, Estado do Amazonas, Brasil, com a finalidade de estudar a prevalência dos antígenos de HLA -A, -B, -C e DR, dentre os quais 38 eram doentes com malária causada pelo Plasmodium falciparum Todos eles foram examinados para avaliação de esplenomegalia, exame parasitológico de sangue e pesquisa de anticorpos de malária. Foram constituídos três grupos: (I) 25 indivíduos nascidos na região Amazônica que nunca tiveram malária; (II) 38 indivíduos naturais da Amazônia que tinham sido tratados de malária no passado, ou que estavam tendo malária atual, e ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Directory of Open Access Journals: DOAJ Articles |
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Malária Plasmodium falciparum Prevalência de HLA Plasmodium falciparum malaria HLA frequency Arctic medicine. Tropical medicine RC955-962 |
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Malária Plasmodium falciparum Prevalência de HLA Plasmodium falciparum malaria HLA frequency Arctic medicine. Tropical medicine RC955-962 Domingos Alves Meira Jordão Pellegrino Júnior Jussara Marcondes-Machado Kimiyoski Tsuji Elinda Satie Matsuoka Elizete Haida Albert Boutros El Khoury Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil |
topic_facet |
Malária Plasmodium falciparum Prevalência de HLA Plasmodium falciparum malaria HLA frequency Arctic medicine. Tropical medicine RC955-962 |
description |
In August 1983,85 inhabitants of the municipality of Humaitá, Amazonas State, Brazil were studied to determine the prevalence of antigens to HLA-A, -B, -C and DR. Thirty-eight were sick with malaria due to Plasmodium falciparum. All subjects were examined for splenomegaly, blood parasitaemia and antibodies to malaria. They constituted three groups: 1) 25 subjects native to the Amazon region who had never had malaria; 2) 38 Amazonian subjects who had malaria in the past or currently had an infection; 3) 22 patients with malaria who had acquired the infection in the Amazon Region but came from other regions of Brazil. Blood was taken from each person, the lymphocytes were separated and typed by the test of microlymphocytotoxicity. There was a high frequency of antigens that could not be identified in the groups studied which suggests the existence of a homozygote or phenotype not identified in the population. There was a high frequency of the phenotype Ag(W24) (44.7%) in group 2 when compared with group 1 (32%) or group 3 (9%). Also the individuals in group 2 showed an elevated frequency of antigen DR(4)80%) when compared with group 1 (36.6%) or group 3 (16.6%). These observations suggest the possibility of a genetic susceptibility to malaria among Amazonian residents and indicate a necessity for more extensive studies of the frequency of HLA antigens among inhabitants of this endemic malarial zone. Em agosto de 1983 foram observados 85 habitantes do Município de Humaitá, Estado do Amazonas, Brasil, com a finalidade de estudar a prevalência dos antígenos de HLA -A, -B, -C e DR, dentre os quais 38 eram doentes com malária causada pelo Plasmodium falciparum Todos eles foram examinados para avaliação de esplenomegalia, exame parasitológico de sangue e pesquisa de anticorpos de malária. Foram constituídos três grupos: (I) 25 indivíduos nascidos na região Amazônica que nunca tiveram malária; (II) 38 indivíduos naturais da Amazônia que tinham sido tratados de malária no passado, ou que estavam tendo malária atual, e ... |
format |
Article in Journal/Newspaper |
author |
Domingos Alves Meira Jordão Pellegrino Júnior Jussara Marcondes-Machado Kimiyoski Tsuji Elinda Satie Matsuoka Elizete Haida Albert Boutros El Khoury |
author_facet |
Domingos Alves Meira Jordão Pellegrino Júnior Jussara Marcondes-Machado Kimiyoski Tsuji Elinda Satie Matsuoka Elizete Haida Albert Boutros El Khoury |
author_sort |
Domingos Alves Meira |
title |
Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil |
title_short |
Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil |
title_full |
Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil |
title_fullStr |
Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil |
title_full_unstemmed |
Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil |
title_sort |
frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of humaitá county, amazonas state, brazil |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
1987 |
url |
https://doaj.org/article/b2b5de65d5a94d2f9649e24a1e3d4c71 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 20, Iss 3, Pp 153-158 (1987) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821987000300005 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 0037-8682 1678-9849 https://doaj.org/article/b2b5de65d5a94d2f9649e24a1e3d4c71 |
_version_ |
1766348330652139520 |