Characterization of a Zika Virus Isolate from Colombia.
Zika virus (Flavivirus genus) is the first mosquito-borne virus known to cause high rates of microcephaly and abortion in humans. Typically, Zika virus causes a self-limiting, systemic illness; however, the current outbreak of Zika virus in the Americas has been associated with increased rates of fe...
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ftdoajarticles:oai:doaj.org/article:b299a55177e7479ba4bcbc2a08f21e98 2023-05-15T15:07:46+02:00 Characterization of a Zika Virus Isolate from Colombia. Anismrita Lahon Ravi P Arya Alexander R Kneubehl Megan B Vogt Natalie J M Dailey Garnes Rebecca Rico-Hesse 2016-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005019 https://doaj.org/article/b299a55177e7479ba4bcbc2a08f21e98 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5031432?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005019 https://doaj.org/article/b299a55177e7479ba4bcbc2a08f21e98 PLoS Neglected Tropical Diseases, Vol 10, Iss 9, p e0005019 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005019 2022-12-31T05:10:52Z Zika virus (Flavivirus genus) is the first mosquito-borne virus known to cause high rates of microcephaly and abortion in humans. Typically, Zika virus causes a self-limiting, systemic illness; however, the current outbreak of Zika virus in the Americas has been associated with increased rates of fetal malformations and Guillain-Barré syndrome. Very few Zika virus isolates have been described in the literature, and live viruses are needed to perform studies of pathogenesis and to develop vaccines and treatments.We isolated Zika virus, strain FLR, directly from the serum of an individual infected in Barranquilla, Colombia (December, 2015). Here, we describe the patient's clinical course and characterize strain FLR by its growth characteristics in mosquito and mammalian cells and its partial resistance to UV-inactivation. The full genome sequence of FLR was also analyzed (including the 3' un-translated region), to determine its probable geographic origin, and to pinpoint structural differences from other Zika virus strains.We anticipate that the study of this low passage, clinical isolate of Zika virus, which is available for worldwide distribution, will help uncover the mechanisms of viral replication and host immune responses contributing to the varied and sometimes severe clinical presentations seen during the current epidemic in the Americas. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Barré ENVELOPE(-68.550,-68.550,-67.500,-67.500) PLOS Neglected Tropical Diseases 10 9 e0005019 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Anismrita Lahon Ravi P Arya Alexander R Kneubehl Megan B Vogt Natalie J M Dailey Garnes Rebecca Rico-Hesse Characterization of a Zika Virus Isolate from Colombia. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Zika virus (Flavivirus genus) is the first mosquito-borne virus known to cause high rates of microcephaly and abortion in humans. Typically, Zika virus causes a self-limiting, systemic illness; however, the current outbreak of Zika virus in the Americas has been associated with increased rates of fetal malformations and Guillain-Barré syndrome. Very few Zika virus isolates have been described in the literature, and live viruses are needed to perform studies of pathogenesis and to develop vaccines and treatments.We isolated Zika virus, strain FLR, directly from the serum of an individual infected in Barranquilla, Colombia (December, 2015). Here, we describe the patient's clinical course and characterize strain FLR by its growth characteristics in mosquito and mammalian cells and its partial resistance to UV-inactivation. The full genome sequence of FLR was also analyzed (including the 3' un-translated region), to determine its probable geographic origin, and to pinpoint structural differences from other Zika virus strains.We anticipate that the study of this low passage, clinical isolate of Zika virus, which is available for worldwide distribution, will help uncover the mechanisms of viral replication and host immune responses contributing to the varied and sometimes severe clinical presentations seen during the current epidemic in the Americas. |
format |
Article in Journal/Newspaper |
author |
Anismrita Lahon Ravi P Arya Alexander R Kneubehl Megan B Vogt Natalie J M Dailey Garnes Rebecca Rico-Hesse |
author_facet |
Anismrita Lahon Ravi P Arya Alexander R Kneubehl Megan B Vogt Natalie J M Dailey Garnes Rebecca Rico-Hesse |
author_sort |
Anismrita Lahon |
title |
Characterization of a Zika Virus Isolate from Colombia. |
title_short |
Characterization of a Zika Virus Isolate from Colombia. |
title_full |
Characterization of a Zika Virus Isolate from Colombia. |
title_fullStr |
Characterization of a Zika Virus Isolate from Colombia. |
title_full_unstemmed |
Characterization of a Zika Virus Isolate from Colombia. |
title_sort |
characterization of a zika virus isolate from colombia. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0005019 https://doaj.org/article/b299a55177e7479ba4bcbc2a08f21e98 |
long_lat |
ENVELOPE(-68.550,-68.550,-67.500,-67.500) |
geographic |
Arctic Barré |
geographic_facet |
Arctic Barré |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 9, p e0005019 (2016) |
op_relation |
http://europepmc.org/articles/PMC5031432?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005019 https://doaj.org/article/b299a55177e7479ba4bcbc2a08f21e98 |
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https://doi.org/10.1371/journal.pntd.0005019 |
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PLOS Neglected Tropical Diseases |
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10 |
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9 |
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e0005019 |
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