PTSD patients show increasing cytokine levels during treatment despite reduced psychological distress
Helge Toft,1,2 Jørgen G Bramness,1,3 Lars Lien,1,4 Dawit S Abebe,1,5 Bruce E Wampold,6,7 Terje Tilden,6 Knut Hestad,4,8,9 Sudan Prasad Neupane1,10 1Norwegian National Advisory Unit on Concurrent Substance Abuse and Mental Health Disorders, Innlandet Hospital Trust, Ottestad, Norway; 2Institute of Cl...
Main Authors: | , , , , , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Dove Medical Press
2018
|
Subjects: | |
Online Access: | https://doaj.org/article/b29589b3851b428fb3f76b4ca906fca4 |
id |
ftdoajarticles:oai:doaj.org/article:b29589b3851b428fb3f76b4ca906fca4 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:b29589b3851b428fb3f76b4ca906fca4 2023-05-15T15:15:05+02:00 PTSD patients show increasing cytokine levels during treatment despite reduced psychological distress Toft H Bramness JG Lien L Abebe DS Wampold BE Tilden T Hestad KA Neupane SP 2018-09-01T00:00:00Z https://doaj.org/article/b29589b3851b428fb3f76b4ca906fca4 EN eng Dove Medical Press https://www.dovepress.com/ptsd-patients-show-increasing-cytokine-levels-during-treatment-despite-peer-reviewed-article-NDT https://doaj.org/toc/1178-2021 1178-2021 https://doaj.org/article/b29589b3851b428fb3f76b4ca906fca4 Neuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2367-2378 (2018) Cytokines trauma inflammation PTSD immune activation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 article 2018 ftdoajarticles 2022-12-31T11:40:34Z Helge Toft,1,2 Jørgen G Bramness,1,3 Lars Lien,1,4 Dawit S Abebe,1,5 Bruce E Wampold,6,7 Terje Tilden,6 Knut Hestad,4,8,9 Sudan Prasad Neupane1,10 1Norwegian National Advisory Unit on Concurrent Substance Abuse and Mental Health Disorders, Innlandet Hospital Trust, Ottestad, Norway; 2Institute of Clinical Medicine, University of Oslo, Oslo, Norway; 3Institute of Clinical Medicine, UiT, Norway's Arctic University, Tromsø, Norway; 4Department of Health Studies, Inland Norway University of Applied Sciences, Elverum, Norway; 5Department of Nursing and Health Promotion, Oslo Metropolitan University, Oslo, Norway; 6Research Institute, Modum Psychiatric Center, Vikersund, Norway; 7Department of Counseling Psychology, University of Wisconsin-Madison, Madison, WI, USA; 8Department of Research, Innlandet Hospital Trust, Brumunddal, Norway; 9Department of Psychology, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; 10Norwegian Center for Addiction Research (SERAF), Institute of Clinical Medicine, University of Oslo, Oslo, Norway Background: A reciprocal relationship between activated innate immune system and changes in mood and behavior has been established. There is still a paucity of knowledge on how the immune system responds during psychiatric treatment. We aimed to explore circulating cytokines and assess psychiatric symptom severity scores during 12 weeks of inpatient psychiatric treatment. Methods: The study was a longitudinal assessment of 124 patients (88 women and 36 men) in treatment at Modum Psychiatric Center, Norway. The patient sample comprised a mixed psychiatric population of whom 39 were diagnosed with posttraumatic stress disorder (PTSD). Serum blood samples for cytokine analysis and measures of mental distress using Global Severity Index were collected at admission (T0), halfway (T1), and before discharge (T2). Other factors assessed were age, gender, and the use of antidepressants and anti-inflammatory drugs. Multilevel modeling was used for longitudinal analyses to assess the ... Article in Journal/Newspaper Arctic Tromsø Directory of Open Access Journals: DOAJ Articles Arctic Norway Tromsø Hestad ENVELOPE(7.719,7.719,62.735,62.735) |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Cytokines trauma inflammation PTSD immune activation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
spellingShingle |
Cytokines trauma inflammation PTSD immune activation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Toft H Bramness JG Lien L Abebe DS Wampold BE Tilden T Hestad KA Neupane SP PTSD patients show increasing cytokine levels during treatment despite reduced psychological distress |
topic_facet |
Cytokines trauma inflammation PTSD immune activation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
description |
Helge Toft,1,2 Jørgen G Bramness,1,3 Lars Lien,1,4 Dawit S Abebe,1,5 Bruce E Wampold,6,7 Terje Tilden,6 Knut Hestad,4,8,9 Sudan Prasad Neupane1,10 1Norwegian National Advisory Unit on Concurrent Substance Abuse and Mental Health Disorders, Innlandet Hospital Trust, Ottestad, Norway; 2Institute of Clinical Medicine, University of Oslo, Oslo, Norway; 3Institute of Clinical Medicine, UiT, Norway's Arctic University, Tromsø, Norway; 4Department of Health Studies, Inland Norway University of Applied Sciences, Elverum, Norway; 5Department of Nursing and Health Promotion, Oslo Metropolitan University, Oslo, Norway; 6Research Institute, Modum Psychiatric Center, Vikersund, Norway; 7Department of Counseling Psychology, University of Wisconsin-Madison, Madison, WI, USA; 8Department of Research, Innlandet Hospital Trust, Brumunddal, Norway; 9Department of Psychology, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; 10Norwegian Center for Addiction Research (SERAF), Institute of Clinical Medicine, University of Oslo, Oslo, Norway Background: A reciprocal relationship between activated innate immune system and changes in mood and behavior has been established. There is still a paucity of knowledge on how the immune system responds during psychiatric treatment. We aimed to explore circulating cytokines and assess psychiatric symptom severity scores during 12 weeks of inpatient psychiatric treatment. Methods: The study was a longitudinal assessment of 124 patients (88 women and 36 men) in treatment at Modum Psychiatric Center, Norway. The patient sample comprised a mixed psychiatric population of whom 39 were diagnosed with posttraumatic stress disorder (PTSD). Serum blood samples for cytokine analysis and measures of mental distress using Global Severity Index were collected at admission (T0), halfway (T1), and before discharge (T2). Other factors assessed were age, gender, and the use of antidepressants and anti-inflammatory drugs. Multilevel modeling was used for longitudinal analyses to assess the ... |
format |
Article in Journal/Newspaper |
author |
Toft H Bramness JG Lien L Abebe DS Wampold BE Tilden T Hestad KA Neupane SP |
author_facet |
Toft H Bramness JG Lien L Abebe DS Wampold BE Tilden T Hestad KA Neupane SP |
author_sort |
Toft H |
title |
PTSD patients show increasing cytokine levels during treatment despite reduced psychological distress |
title_short |
PTSD patients show increasing cytokine levels during treatment despite reduced psychological distress |
title_full |
PTSD patients show increasing cytokine levels during treatment despite reduced psychological distress |
title_fullStr |
PTSD patients show increasing cytokine levels during treatment despite reduced psychological distress |
title_full_unstemmed |
PTSD patients show increasing cytokine levels during treatment despite reduced psychological distress |
title_sort |
ptsd patients show increasing cytokine levels during treatment despite reduced psychological distress |
publisher |
Dove Medical Press |
publishDate |
2018 |
url |
https://doaj.org/article/b29589b3851b428fb3f76b4ca906fca4 |
long_lat |
ENVELOPE(7.719,7.719,62.735,62.735) |
geographic |
Arctic Norway Tromsø Hestad |
geographic_facet |
Arctic Norway Tromsø Hestad |
genre |
Arctic Tromsø |
genre_facet |
Arctic Tromsø |
op_source |
Neuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2367-2378 (2018) |
op_relation |
https://www.dovepress.com/ptsd-patients-show-increasing-cytokine-levels-during-treatment-despite-peer-reviewed-article-NDT https://doaj.org/toc/1178-2021 1178-2021 https://doaj.org/article/b29589b3851b428fb3f76b4ca906fca4 |
_version_ |
1766345463218307072 |