Neurotropic effects of aspartame, stevia and sucralose on memory retention and on the histology of the hippocampus of the ICR mice (Mus musculus)
Objective: To identify the effects of the consumption of non-nutritive sweeteners on memory retention and on the histology of the hippocampus. Methods: In this study, 20 mice were used to determine if there is an effect of consuming the maximum allowable dose of the non-nutritive sweeteners on the m...
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Wolters Kluwer Medknow Publications
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ftdoajarticles:oai:doaj.org/article:b255188a184c4d45bc977ba958811e58 2023-05-15T15:08:48+02:00 Neurotropic effects of aspartame, stevia and sucralose on memory retention and on the histology of the hippocampus of the ICR mice (Mus musculus) Lejan Miguel Alabastro Villareal Rachelle Anne Montes Cruz Michael Bagui Ples Rodel Jonathan Santos Vitor, II 2016-02-01T00:00:00Z https://doi.org/10.1016/j.apjtb.2015.11.001 https://doaj.org/article/b255188a184c4d45bc977ba958811e58 EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169115002555 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2015.11.001 https://doaj.org/article/b255188a184c4d45bc977ba958811e58 Asian Pacific Journal of Tropical Biomedicine, Vol 6, Iss 2, Pp 114-118 (2016) Aspartame Hippocampus Learning Memory Mus musculus Stevia Sucralose Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2016 ftdoajarticles https://doi.org/10.1016/j.apjtb.2015.11.001 2022-12-31T13:09:52Z Objective: To identify the effects of the consumption of non-nutritive sweeteners on memory retention and on the histology of the hippocampus. Methods: In this study, 20 mice were used to determine if there is an effect of consuming the maximum allowable dose of the non-nutritive sweeteners on the memory retention and on the histology of the hippocampus. The mice were distributed into four groups and the treatments were given via oral gavage: Group 1 (water), Group 2 (aspartame: 1000 mg/kg), Group 3 (stevia: 1000 mg/kg) and Group 4 (sucralose: 16000 mg/kg). Treatments were administered to the different experimental groups for 32 days, after which memory retention was tested using the two-day water maze protocol. After the tests, the mice were sacrificed and the brain was analyzed histologically for neurotrophic effects. Results: Based on the results of the two-day water maze protocol, there were no differences between the non-nutritive sweeteners and the control group. However, stevia showed high cellular apoptosis followed by aspartame, sucralose and control group. Conclusions: There was no significant effect on the memory of the mice. It showed histologically however, that stevia had a significant neurotropic effect compared to the other sweeteners. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 6 2 114 118 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Aspartame Hippocampus Learning Memory Mus musculus Stevia Sucralose Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Aspartame Hippocampus Learning Memory Mus musculus Stevia Sucralose Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Lejan Miguel Alabastro Villareal Rachelle Anne Montes Cruz Michael Bagui Ples Rodel Jonathan Santos Vitor, II Neurotropic effects of aspartame, stevia and sucralose on memory retention and on the histology of the hippocampus of the ICR mice (Mus musculus) |
topic_facet |
Aspartame Hippocampus Learning Memory Mus musculus Stevia Sucralose Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To identify the effects of the consumption of non-nutritive sweeteners on memory retention and on the histology of the hippocampus. Methods: In this study, 20 mice were used to determine if there is an effect of consuming the maximum allowable dose of the non-nutritive sweeteners on the memory retention and on the histology of the hippocampus. The mice were distributed into four groups and the treatments were given via oral gavage: Group 1 (water), Group 2 (aspartame: 1000 mg/kg), Group 3 (stevia: 1000 mg/kg) and Group 4 (sucralose: 16000 mg/kg). Treatments were administered to the different experimental groups for 32 days, after which memory retention was tested using the two-day water maze protocol. After the tests, the mice were sacrificed and the brain was analyzed histologically for neurotrophic effects. Results: Based on the results of the two-day water maze protocol, there were no differences between the non-nutritive sweeteners and the control group. However, stevia showed high cellular apoptosis followed by aspartame, sucralose and control group. Conclusions: There was no significant effect on the memory of the mice. It showed histologically however, that stevia had a significant neurotropic effect compared to the other sweeteners. |
format |
Article in Journal/Newspaper |
author |
Lejan Miguel Alabastro Villareal Rachelle Anne Montes Cruz Michael Bagui Ples Rodel Jonathan Santos Vitor, II |
author_facet |
Lejan Miguel Alabastro Villareal Rachelle Anne Montes Cruz Michael Bagui Ples Rodel Jonathan Santos Vitor, II |
author_sort |
Lejan Miguel Alabastro Villareal |
title |
Neurotropic effects of aspartame, stevia and sucralose on memory retention and on the histology of the hippocampus of the ICR mice (Mus musculus) |
title_short |
Neurotropic effects of aspartame, stevia and sucralose on memory retention and on the histology of the hippocampus of the ICR mice (Mus musculus) |
title_full |
Neurotropic effects of aspartame, stevia and sucralose on memory retention and on the histology of the hippocampus of the ICR mice (Mus musculus) |
title_fullStr |
Neurotropic effects of aspartame, stevia and sucralose on memory retention and on the histology of the hippocampus of the ICR mice (Mus musculus) |
title_full_unstemmed |
Neurotropic effects of aspartame, stevia and sucralose on memory retention and on the histology of the hippocampus of the ICR mice (Mus musculus) |
title_sort |
neurotropic effects of aspartame, stevia and sucralose on memory retention and on the histology of the hippocampus of the icr mice (mus musculus) |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2016 |
url |
https://doi.org/10.1016/j.apjtb.2015.11.001 https://doaj.org/article/b255188a184c4d45bc977ba958811e58 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 6, Iss 2, Pp 114-118 (2016) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169115002555 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2015.11.001 https://doaj.org/article/b255188a184c4d45bc977ba958811e58 |
op_doi |
https://doi.org/10.1016/j.apjtb.2015.11.001 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
6 |
container_issue |
2 |
container_start_page |
114 |
op_container_end_page |
118 |
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1766340094318346240 |