Evaluation of DawaPlus 3.0 and DawaPlus 4.0, deltamethrin–PBO combination nets against pyrethroid-resistant Anopheles culicifacies in experimental huts in India
Abstract Background The development of resistance in vectors is one of the major impediments for malaria control. Adding synergists to insecticides has proven to be an alternative choice for controlling resistant mosquitoes. DawaPlus 3.0 and DawaPlus 4.0 are new long-lasting insecticidal nets (LLINs...
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ftdoajarticles:oai:doaj.org/article:b250bc62217b445586603d9df7c61bbc 2023-05-15T15:08:15+02:00 Evaluation of DawaPlus 3.0 and DawaPlus 4.0, deltamethrin–PBO combination nets against pyrethroid-resistant Anopheles culicifacies in experimental huts in India Kasinathan Gunasekaran Sudhansu Sekhar Sahu Tharmalingam Vijayakumar Swaminathan Subramanian Manju Rahi Purushothaman Jambulingam 2020-01-01T00:00:00Z https://doi.org/10.1186/s12936-020-3119-x https://doaj.org/article/b250bc62217b445586603d9df7c61bbc EN eng BMC https://doi.org/10.1186/s12936-020-3119-x https://doaj.org/toc/1475-2875 doi:10.1186/s12936-020-3119-x 1475-2875 https://doaj.org/article/b250bc62217b445586603d9df7c61bbc Malaria Journal, Vol 19, Iss 1, Pp 1-9 (2020) Anopheles culicifacies DawaPlus 3.0 DawaPlus 4.0 Experimental huts India Piperonyl butoxide Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2020 ftdoajarticles https://doi.org/10.1186/s12936-020-3119-x 2022-12-31T13:03:06Z Abstract Background The development of resistance in vectors is one of the major impediments for malaria control. Adding synergists to insecticides has proven to be an alternative choice for controlling resistant mosquitoes. DawaPlus 3.0 and DawaPlus 4.0 are new long-lasting insecticidal nets (LLINs) in which deltamethrin and a synergist, piperonyl butoxide (PBO) are added into filaments and their efficacy was tested against resistant malaria vector, Anopheles culicifacies in experimental huts in India. Methods The performance of two trial nets in terms of deterrence induced exiting, blood-feeding inhibition and mortality of An. culicifacies was compared with DawaPlus 2.0 and untreated net. Results There was a significant reduction in entry, blood feeding and mortality (p < 0.05) and increase in exit rates of An. culicifacies in the treatment arms compared to untreated arm. But, both candidate LNs washed 20 times could not perform better than the washed reference net (DawaPlus 2.0). Cone bioassay results showed that all the treatment arms (both washed and unwashed) produced < 80% mortality of An. culicifacies before and after hut evaluation. Conclusions DawaPlus 3.0 and DawaPlus 4.0 with their current specification may not be as effective as required to control the resistant vector, An. culicifacies, in east-central India. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 19 1 |
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Directory of Open Access Journals: DOAJ Articles |
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Anopheles culicifacies DawaPlus 3.0 DawaPlus 4.0 Experimental huts India Piperonyl butoxide Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Anopheles culicifacies DawaPlus 3.0 DawaPlus 4.0 Experimental huts India Piperonyl butoxide Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Kasinathan Gunasekaran Sudhansu Sekhar Sahu Tharmalingam Vijayakumar Swaminathan Subramanian Manju Rahi Purushothaman Jambulingam Evaluation of DawaPlus 3.0 and DawaPlus 4.0, deltamethrin–PBO combination nets against pyrethroid-resistant Anopheles culicifacies in experimental huts in India |
topic_facet |
Anopheles culicifacies DawaPlus 3.0 DawaPlus 4.0 Experimental huts India Piperonyl butoxide Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background The development of resistance in vectors is one of the major impediments for malaria control. Adding synergists to insecticides has proven to be an alternative choice for controlling resistant mosquitoes. DawaPlus 3.0 and DawaPlus 4.0 are new long-lasting insecticidal nets (LLINs) in which deltamethrin and a synergist, piperonyl butoxide (PBO) are added into filaments and their efficacy was tested against resistant malaria vector, Anopheles culicifacies in experimental huts in India. Methods The performance of two trial nets in terms of deterrence induced exiting, blood-feeding inhibition and mortality of An. culicifacies was compared with DawaPlus 2.0 and untreated net. Results There was a significant reduction in entry, blood feeding and mortality (p < 0.05) and increase in exit rates of An. culicifacies in the treatment arms compared to untreated arm. But, both candidate LNs washed 20 times could not perform better than the washed reference net (DawaPlus 2.0). Cone bioassay results showed that all the treatment arms (both washed and unwashed) produced < 80% mortality of An. culicifacies before and after hut evaluation. Conclusions DawaPlus 3.0 and DawaPlus 4.0 with their current specification may not be as effective as required to control the resistant vector, An. culicifacies, in east-central India. |
format |
Article in Journal/Newspaper |
author |
Kasinathan Gunasekaran Sudhansu Sekhar Sahu Tharmalingam Vijayakumar Swaminathan Subramanian Manju Rahi Purushothaman Jambulingam |
author_facet |
Kasinathan Gunasekaran Sudhansu Sekhar Sahu Tharmalingam Vijayakumar Swaminathan Subramanian Manju Rahi Purushothaman Jambulingam |
author_sort |
Kasinathan Gunasekaran |
title |
Evaluation of DawaPlus 3.0 and DawaPlus 4.0, deltamethrin–PBO combination nets against pyrethroid-resistant Anopheles culicifacies in experimental huts in India |
title_short |
Evaluation of DawaPlus 3.0 and DawaPlus 4.0, deltamethrin–PBO combination nets against pyrethroid-resistant Anopheles culicifacies in experimental huts in India |
title_full |
Evaluation of DawaPlus 3.0 and DawaPlus 4.0, deltamethrin–PBO combination nets against pyrethroid-resistant Anopheles culicifacies in experimental huts in India |
title_fullStr |
Evaluation of DawaPlus 3.0 and DawaPlus 4.0, deltamethrin–PBO combination nets against pyrethroid-resistant Anopheles culicifacies in experimental huts in India |
title_full_unstemmed |
Evaluation of DawaPlus 3.0 and DawaPlus 4.0, deltamethrin–PBO combination nets against pyrethroid-resistant Anopheles culicifacies in experimental huts in India |
title_sort |
evaluation of dawaplus 3.0 and dawaplus 4.0, deltamethrin–pbo combination nets against pyrethroid-resistant anopheles culicifacies in experimental huts in india |
publisher |
BMC |
publishDate |
2020 |
url |
https://doi.org/10.1186/s12936-020-3119-x https://doaj.org/article/b250bc62217b445586603d9df7c61bbc |
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Arctic |
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Arctic |
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Arctic |
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Arctic |
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Malaria Journal, Vol 19, Iss 1, Pp 1-9 (2020) |
op_relation |
https://doi.org/10.1186/s12936-020-3119-x https://doaj.org/toc/1475-2875 doi:10.1186/s12936-020-3119-x 1475-2875 https://doaj.org/article/b250bc62217b445586603d9df7c61bbc |
op_doi |
https://doi.org/10.1186/s12936-020-3119-x |
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Malaria Journal |
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19 |
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1 |
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1766339647429935104 |