Evaluation of DawaPlus 3.0 and DawaPlus 4.0, deltamethrin–PBO combination nets against pyrethroid-resistant Anopheles culicifacies in experimental huts in India

Abstract Background The development of resistance in vectors is one of the major impediments for malaria control. Adding synergists to insecticides has proven to be an alternative choice for controlling resistant mosquitoes. DawaPlus 3.0 and DawaPlus 4.0 are new long-lasting insecticidal nets (LLINs...

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Bibliographic Details
Published in:Malaria Journal
Main Authors: Kasinathan Gunasekaran, Sudhansu Sekhar Sahu, Tharmalingam Vijayakumar, Swaminathan Subramanian, Manju Rahi, Purushothaman Jambulingam
Format: Article in Journal/Newspaper
Language:English
Published: BMC 2020
Subjects:
Anopheles culicifacies
DawaPlus 3.0
DawaPlus 4.0
Experimental huts
India
Piperonyl butoxide
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
Arctic
Online Access:https://doi.org/10.1186/s12936-020-3119-x
https://doaj.org/article/b250bc62217b445586603d9df7c61bbc
Description
Summary:Abstract Background The development of resistance in vectors is one of the major impediments for malaria control. Adding synergists to insecticides has proven to be an alternative choice for controlling resistant mosquitoes. DawaPlus 3.0 and DawaPlus 4.0 are new long-lasting insecticidal nets (LLINs) in which deltamethrin and a synergist, piperonyl butoxide (PBO) are added into filaments and their efficacy was tested against resistant malaria vector, Anopheles culicifacies in experimental huts in India. Methods The performance of two trial nets in terms of deterrence induced exiting, blood-feeding inhibition and mortality of An. culicifacies was compared with DawaPlus 2.0 and untreated net. Results There was a significant reduction in entry, blood feeding and mortality (p < 0.05) and increase in exit rates of An. culicifacies in the treatment arms compared to untreated arm. But, both candidate LNs washed 20 times could not perform better than the washed reference net (DawaPlus 2.0). Cone bioassay results showed that all the treatment arms (both washed and unwashed) produced < 80% mortality of An. culicifacies before and after hut evaluation. Conclusions DawaPlus 3.0 and DawaPlus 4.0 with their current specification may not be as effective as required to control the resistant vector, An. culicifacies, in east-central India.

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