Neonatal Tetanus Immunity in Nigeria: The Effect of HIV Infection on Serum Levels and Transplacental Transfer of Antibodies
Background. Tetanus toxoid immunisation of pregnant mother has remained the most effective strategy in eliminating neonatal tetanus. Impaired production and/or transplacental transfer of antibodies may affect the effectiveness of this strategy. We studied the effect of maternal HIV infection on seru...
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ftdoajarticles:oai:doaj.org/article:b24e2a198f764cbcb23052904e1dc009 2023-05-15T15:07:46+02:00 Neonatal Tetanus Immunity in Nigeria: The Effect of HIV Infection on Serum Levels and Transplacental Transfer of Antibodies Muhammad Faruk Bashir Hassan Abdullahi Elechi Mohammed Garba Ashir Adamu Ibrahim Rabasa David Nadeba Bukbuk Ahmadu Baba Usman Modu Gofama Mustapha Mohammad Arab Alhaji 2016-01-01T00:00:00Z https://doi.org/10.1155/2016/7439605 https://doaj.org/article/b24e2a198f764cbcb23052904e1dc009 EN eng Hindawi Limited http://dx.doi.org/10.1155/2016/7439605 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2016/7439605 https://doaj.org/article/b24e2a198f764cbcb23052904e1dc009 Journal of Tropical Medicine, Vol 2016 (2016) Arctic medicine. Tropical medicine RC955-962 article 2016 ftdoajarticles https://doi.org/10.1155/2016/7439605 2022-12-31T14:06:05Z Background. Tetanus toxoid immunisation of pregnant mother has remained the most effective strategy in eliminating neonatal tetanus. Impaired production and/or transplacental transfer of antibodies may affect the effectiveness of this strategy. We studied the effect of maternal HIV infection on serum levels and transplacental transfer of anti-tetanus antibodies. Methods. A total of 162 mother-baby paired serum samples were taken and analysed for anti-tetanus antibody levels using ELISA. Maternal HIV status was also determined by double ELISA technique. Maternal TT vaccination status was also documented. Results. Thirty-eight (23.5%) mothers and 41 (25.3%) babies were seronegative, out of whom 8 mothers were HIV positive and 9 babies were HIV exposed. HIV infected mothers and HIV exposed infants were, respectively, 16.27 times (OR = 16.27, 95% CI = 3.28 to 80.61) and 33.75 times (OR = 33.75, 95% CI = 4.12 to 276.40) more likely to be seronegative for anti-tetanus antibody. Similarly, HIV positive mother-newborn pairs were 7.46 times more likely to have a poor transplacental transfer of tetanus antibodies (OR = 7.46, 95% CI = 1.96 to 28.41). Conclusions. Maternal HIV infection is associated with impaired maternofoetal transfer of anti-tetanus antibodies and seronegativity among mothers and their newborns. Hence, this may hinder efforts to eliminate neonatal tetanus. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2016 1 6 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
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Arctic medicine. Tropical medicine RC955-962 Muhammad Faruk Bashir Hassan Abdullahi Elechi Mohammed Garba Ashir Adamu Ibrahim Rabasa David Nadeba Bukbuk Ahmadu Baba Usman Modu Gofama Mustapha Mohammad Arab Alhaji Neonatal Tetanus Immunity in Nigeria: The Effect of HIV Infection on Serum Levels and Transplacental Transfer of Antibodies |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Background. Tetanus toxoid immunisation of pregnant mother has remained the most effective strategy in eliminating neonatal tetanus. Impaired production and/or transplacental transfer of antibodies may affect the effectiveness of this strategy. We studied the effect of maternal HIV infection on serum levels and transplacental transfer of anti-tetanus antibodies. Methods. A total of 162 mother-baby paired serum samples were taken and analysed for anti-tetanus antibody levels using ELISA. Maternal HIV status was also determined by double ELISA technique. Maternal TT vaccination status was also documented. Results. Thirty-eight (23.5%) mothers and 41 (25.3%) babies were seronegative, out of whom 8 mothers were HIV positive and 9 babies were HIV exposed. HIV infected mothers and HIV exposed infants were, respectively, 16.27 times (OR = 16.27, 95% CI = 3.28 to 80.61) and 33.75 times (OR = 33.75, 95% CI = 4.12 to 276.40) more likely to be seronegative for anti-tetanus antibody. Similarly, HIV positive mother-newborn pairs were 7.46 times more likely to have a poor transplacental transfer of tetanus antibodies (OR = 7.46, 95% CI = 1.96 to 28.41). Conclusions. Maternal HIV infection is associated with impaired maternofoetal transfer of anti-tetanus antibodies and seronegativity among mothers and their newborns. Hence, this may hinder efforts to eliminate neonatal tetanus. |
format |
Article in Journal/Newspaper |
author |
Muhammad Faruk Bashir Hassan Abdullahi Elechi Mohammed Garba Ashir Adamu Ibrahim Rabasa David Nadeba Bukbuk Ahmadu Baba Usman Modu Gofama Mustapha Mohammad Arab Alhaji |
author_facet |
Muhammad Faruk Bashir Hassan Abdullahi Elechi Mohammed Garba Ashir Adamu Ibrahim Rabasa David Nadeba Bukbuk Ahmadu Baba Usman Modu Gofama Mustapha Mohammad Arab Alhaji |
author_sort |
Muhammad Faruk Bashir |
title |
Neonatal Tetanus Immunity in Nigeria: The Effect of HIV Infection on Serum Levels and Transplacental Transfer of Antibodies |
title_short |
Neonatal Tetanus Immunity in Nigeria: The Effect of HIV Infection on Serum Levels and Transplacental Transfer of Antibodies |
title_full |
Neonatal Tetanus Immunity in Nigeria: The Effect of HIV Infection on Serum Levels and Transplacental Transfer of Antibodies |
title_fullStr |
Neonatal Tetanus Immunity in Nigeria: The Effect of HIV Infection on Serum Levels and Transplacental Transfer of Antibodies |
title_full_unstemmed |
Neonatal Tetanus Immunity in Nigeria: The Effect of HIV Infection on Serum Levels and Transplacental Transfer of Antibodies |
title_sort |
neonatal tetanus immunity in nigeria: the effect of hiv infection on serum levels and transplacental transfer of antibodies |
publisher |
Hindawi Limited |
publishDate |
2016 |
url |
https://doi.org/10.1155/2016/7439605 https://doaj.org/article/b24e2a198f764cbcb23052904e1dc009 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2016 (2016) |
op_relation |
http://dx.doi.org/10.1155/2016/7439605 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2016/7439605 https://doaj.org/article/b24e2a198f764cbcb23052904e1dc009 |
op_doi |
https://doi.org/10.1155/2016/7439605 |
container_title |
Journal of Tropical Medicine |
container_volume |
2016 |
container_start_page |
1 |
op_container_end_page |
6 |
_version_ |
1766339196599926784 |