Iquitos virus: a novel reassortant Orthobunyavirus associated with human illness in Peru.
Oropouche (ORO) virus, a member of the Simbu serogroup, is one of the few human pathogens in the Orthobunyavirus genus in the family Bunyaviridae. Genetic analyses of ORO-like strains from Iquitos, Peru, identified a novel reassortant containing the S and L segments of ORO virus and the M segment of...
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ftdoajarticles:oai:doaj.org/article:b238878513f84445b6090537547c6d1a 2023-05-15T15:07:54+02:00 Iquitos virus: a novel reassortant Orthobunyavirus associated with human illness in Peru. Patricia V Aguilar Alan D Barrett Mohammad F Saeed Douglas M Watts Kevin Russell Carolina Guevara Julia S Ampuero Luis Suarez Manuel Cespedes Joel M Montgomery Eric S Halsey Tadeusz J Kochel 2011-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001315 https://doaj.org/article/b238878513f84445b6090537547c6d1a EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3176741?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001315 https://doaj.org/article/b238878513f84445b6090537547c6d1a PLoS Neglected Tropical Diseases, Vol 5, Iss 9, p e1315 (2011) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2011 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001315 2022-12-31T10:36:08Z Oropouche (ORO) virus, a member of the Simbu serogroup, is one of the few human pathogens in the Orthobunyavirus genus in the family Bunyaviridae. Genetic analyses of ORO-like strains from Iquitos, Peru, identified a novel reassortant containing the S and L segments of ORO virus and the M segment of a novel Simbu serogroup virus. This new pathogen, which we named Iquitos (IQT) virus, was first isolated during 1999 from a febrile patient in Iquitos, an Amazonian city in Peru. Subsequently, the virus was identified as the cause of outbreaks of "Oropouche fever" during 2005 and 2006 in Iquitos. In addition to the identification of 17 isolates of IQT virus between 1999 and 2006, surveys for neutralizing antibody among Iquitos residents revealed prevalence rates of 14.9% for ORO virus and 15.4% for IQT virus. Limited studies indicate that prior infection with ORO virus does not seem to protect against disease caused with the IQT virus infection. Identification of a new Orthobunyavirus human pathogen in the Amazon region of Peru highlights the need for strengthening surveillance activities and laboratory capabilities, and investigating the emergence of new pathogens in tropical regions of South America. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 5 9 e1315 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Patricia V Aguilar Alan D Barrett Mohammad F Saeed Douglas M Watts Kevin Russell Carolina Guevara Julia S Ampuero Luis Suarez Manuel Cespedes Joel M Montgomery Eric S Halsey Tadeusz J Kochel Iquitos virus: a novel reassortant Orthobunyavirus associated with human illness in Peru. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Oropouche (ORO) virus, a member of the Simbu serogroup, is one of the few human pathogens in the Orthobunyavirus genus in the family Bunyaviridae. Genetic analyses of ORO-like strains from Iquitos, Peru, identified a novel reassortant containing the S and L segments of ORO virus and the M segment of a novel Simbu serogroup virus. This new pathogen, which we named Iquitos (IQT) virus, was first isolated during 1999 from a febrile patient in Iquitos, an Amazonian city in Peru. Subsequently, the virus was identified as the cause of outbreaks of "Oropouche fever" during 2005 and 2006 in Iquitos. In addition to the identification of 17 isolates of IQT virus between 1999 and 2006, surveys for neutralizing antibody among Iquitos residents revealed prevalence rates of 14.9% for ORO virus and 15.4% for IQT virus. Limited studies indicate that prior infection with ORO virus does not seem to protect against disease caused with the IQT virus infection. Identification of a new Orthobunyavirus human pathogen in the Amazon region of Peru highlights the need for strengthening surveillance activities and laboratory capabilities, and investigating the emergence of new pathogens in tropical regions of South America. |
format |
Article in Journal/Newspaper |
author |
Patricia V Aguilar Alan D Barrett Mohammad F Saeed Douglas M Watts Kevin Russell Carolina Guevara Julia S Ampuero Luis Suarez Manuel Cespedes Joel M Montgomery Eric S Halsey Tadeusz J Kochel |
author_facet |
Patricia V Aguilar Alan D Barrett Mohammad F Saeed Douglas M Watts Kevin Russell Carolina Guevara Julia S Ampuero Luis Suarez Manuel Cespedes Joel M Montgomery Eric S Halsey Tadeusz J Kochel |
author_sort |
Patricia V Aguilar |
title |
Iquitos virus: a novel reassortant Orthobunyavirus associated with human illness in Peru. |
title_short |
Iquitos virus: a novel reassortant Orthobunyavirus associated with human illness in Peru. |
title_full |
Iquitos virus: a novel reassortant Orthobunyavirus associated with human illness in Peru. |
title_fullStr |
Iquitos virus: a novel reassortant Orthobunyavirus associated with human illness in Peru. |
title_full_unstemmed |
Iquitos virus: a novel reassortant Orthobunyavirus associated with human illness in Peru. |
title_sort |
iquitos virus: a novel reassortant orthobunyavirus associated with human illness in peru. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2011 |
url |
https://doi.org/10.1371/journal.pntd.0001315 https://doaj.org/article/b238878513f84445b6090537547c6d1a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 5, Iss 9, p e1315 (2011) |
op_relation |
http://europepmc.org/articles/PMC3176741?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001315 https://doaj.org/article/b238878513f84445b6090537547c6d1a |
op_doi |
https://doi.org/10.1371/journal.pntd.0001315 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
5 |
container_issue |
9 |
container_start_page |
e1315 |
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1766339330623668224 |