An evaluation of Brazil's surveillance and prophylaxis of canine rabies between 2008 and 2017.
An effective surveillance system is critical for the elimination of canine rabies in Latin America. Brazil has made substantial progress towards canine rabies elimination, but outbreaks still occurred in the last decade in two states. Brazil uses a health information system (SINAN) to record patient...
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ftdoajarticles:oai:doaj.org/article:b1f50642a37749d4b5d607726ca9f91f 2023-05-15T15:16:13+02:00 An evaluation of Brazil's surveillance and prophylaxis of canine rabies between 2008 and 2017. Julio A Benavides Jane Megid Aline Campos Silene Rocha Marco A N Vigilato Katie Hampson 2019-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007564 https://doaj.org/article/b1f50642a37749d4b5d607726ca9f91f EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0007564 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007564 https://doaj.org/article/b1f50642a37749d4b5d607726ca9f91f PLoS Neglected Tropical Diseases, Vol 13, Iss 8, p e0007564 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007564 2022-12-31T13:53:26Z An effective surveillance system is critical for the elimination of canine rabies in Latin America. Brazil has made substantial progress towards canine rabies elimination, but outbreaks still occurred in the last decade in two states. Brazil uses a health information system (SINAN) to record patients seeking post-exposure prophylaxis (PEP) following contact with an animal suspected of having rabies. This study evaluated: (i) whether SINAN can be reliably used for rabies surveillance; (ii) if patients in Brazil are receiving appropriate PEP and (iii) the benefits of implementing the latest World Health Organization (WHO) recommendations on PEP. Analysing SINAN records from 2008 to 2017 reveals an average of 506,148 bite-injury patients/year [range: 437k-545k] in the country, equivalent to an incidence of 255 bite-injuries/100,000 people/year [range: 231-280]. The number of reports of bites from suspect rabid dogs generally increased over time. In most states, records from SINAN indicating a suspect rabid dog do not correlate with confirmed dog rabies cases reported to the Regional Information System for Epidemiological Surveillance of Rabies (SIRVERA) maintained by the Pan American Health Organization (PAHO). Analyses showed that in 2017, only 45% of patients received appropriate PEP as indicated by the Brazilian Ministry of Health guidance. Implementation of the latest WHO guidance using an abridged intradermal post-exposure vaccination regimen including one precautionary dose for dog bites prior to observation would reduce the volume of vaccine required by up to 64%, with potential for annual savings of over USD 6 million from reduced vaccine use. Our results highlight the need to improve the implementation of SINAN, including training of health workers responsible for delivering PEP using an Integrated Bite Case Management approach so that SINAN can serve as a reliable surveillance tool for canine rabies elimination. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 13 8 e0007564 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Julio A Benavides Jane Megid Aline Campos Silene Rocha Marco A N Vigilato Katie Hampson An evaluation of Brazil's surveillance and prophylaxis of canine rabies between 2008 and 2017. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
An effective surveillance system is critical for the elimination of canine rabies in Latin America. Brazil has made substantial progress towards canine rabies elimination, but outbreaks still occurred in the last decade in two states. Brazil uses a health information system (SINAN) to record patients seeking post-exposure prophylaxis (PEP) following contact with an animal suspected of having rabies. This study evaluated: (i) whether SINAN can be reliably used for rabies surveillance; (ii) if patients in Brazil are receiving appropriate PEP and (iii) the benefits of implementing the latest World Health Organization (WHO) recommendations on PEP. Analysing SINAN records from 2008 to 2017 reveals an average of 506,148 bite-injury patients/year [range: 437k-545k] in the country, equivalent to an incidence of 255 bite-injuries/100,000 people/year [range: 231-280]. The number of reports of bites from suspect rabid dogs generally increased over time. In most states, records from SINAN indicating a suspect rabid dog do not correlate with confirmed dog rabies cases reported to the Regional Information System for Epidemiological Surveillance of Rabies (SIRVERA) maintained by the Pan American Health Organization (PAHO). Analyses showed that in 2017, only 45% of patients received appropriate PEP as indicated by the Brazilian Ministry of Health guidance. Implementation of the latest WHO guidance using an abridged intradermal post-exposure vaccination regimen including one precautionary dose for dog bites prior to observation would reduce the volume of vaccine required by up to 64%, with potential for annual savings of over USD 6 million from reduced vaccine use. Our results highlight the need to improve the implementation of SINAN, including training of health workers responsible for delivering PEP using an Integrated Bite Case Management approach so that SINAN can serve as a reliable surveillance tool for canine rabies elimination. |
format |
Article in Journal/Newspaper |
author |
Julio A Benavides Jane Megid Aline Campos Silene Rocha Marco A N Vigilato Katie Hampson |
author_facet |
Julio A Benavides Jane Megid Aline Campos Silene Rocha Marco A N Vigilato Katie Hampson |
author_sort |
Julio A Benavides |
title |
An evaluation of Brazil's surveillance and prophylaxis of canine rabies between 2008 and 2017. |
title_short |
An evaluation of Brazil's surveillance and prophylaxis of canine rabies between 2008 and 2017. |
title_full |
An evaluation of Brazil's surveillance and prophylaxis of canine rabies between 2008 and 2017. |
title_fullStr |
An evaluation of Brazil's surveillance and prophylaxis of canine rabies between 2008 and 2017. |
title_full_unstemmed |
An evaluation of Brazil's surveillance and prophylaxis of canine rabies between 2008 and 2017. |
title_sort |
evaluation of brazil's surveillance and prophylaxis of canine rabies between 2008 and 2017. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0007564 https://doaj.org/article/b1f50642a37749d4b5d607726ca9f91f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 8, p e0007564 (2019) |
op_relation |
https://doi.org/10.1371/journal.pntd.0007564 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007564 https://doaj.org/article/b1f50642a37749d4b5d607726ca9f91f |
op_doi |
https://doi.org/10.1371/journal.pntd.0007564 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
13 |
container_issue |
8 |
container_start_page |
e0007564 |
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1766346509417185280 |