Effect of pancreas disease vaccines on infection levels and virus transmission in Atlantic salmon (Salmo salar) challenged with salmonid alphavirus, genotype 2

• Published in: Frontiers in Immunology
• Main Authors: Ragnar Thorarinsson, Anne Ramstad, Jeffrey C. Wolf, Hilde Sindre, Eystein Skjerve, Espen Rimstad, Øystein Evensen, Jose F. Rodriguez
• Format: Article in Journal/Newspaper
• Language: English
• Published: Frontiers Media S.A. 2024
• Subjects: pancreas disease; salmonid alphavirus; Atlantic salmon; DNA vaccine; vaccine efficacy; viral shedding; Immunologic diseases. Allergy; RC581-607; Sav’; Salmo salar
• Online Access: https://doi.org/10.3389/fimmu.2024.1342816; https://doaj.org/article/b1ae960cf8e24427a09a98d4ff23dbaf

Salmonid alphavirus (SAV) causes pancreas disease (PD), which negatively impacts farmed Atlantic salmon. In this study, fish were vaccinated with a DNA-PD vaccine (DNA-PD) and an oil-adjuvanted, inactivated whole virus PD vaccine (Oil-PD). Controls were two non-PD vaccinated groups. Fish were kept i...