Allolobophora caliginosa coelomic fluid ameliorates gentamicin-induced hepatorenal toxicity in rats

• Published in: Asian Pacific Journal of Tropical Biomedicine
• Main Authors: Saad Bin Dajem, Sara Bayoumi Ali, Omar Ghanem Abdelrady, Nouraldin Mahmoud Salahaldin, Ahmed Muhammed Soliman, Yasmin Mohamed Kamal, Ammar Yasser Abdelazim, Aya Fadi Mohamed, Kareem Morsy, Ayman Saber Mohamed, Sohair Ramadan Fahmy
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wolters Kluwer Medknow Publications 2020
• Subjects: allolobophora caliginosa; coelomic fluid; gentamicin; hepatorenal toxicity; earthworm; Arctic medicine. Tropical medicine; RC955-962; Biology (General); QH301-705.5; Arctic
• Online Access: https://doi.org/10.4103/2221-1691.290132; https://doaj.org/article/b1a06572c45c4b0ab409e0b4edc4a856

Objective: To explore the efficacy of earthworm’s coelomic fluid against gentamicin-induced hepatic and renal toxicity in rats. Methods: The animals were divided randomly into three groups (n = 6 per group): control, gentamicin, and Allolobophora caliginosa coelomic fluid-treated groups. Toxicity was established after injection of gentamicin daily for 8 days at a dose of 100 mg/kg. Aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total proteins, albumin, creatinine, urea, uric acid, malondialdehyde, glutathione, catalase and histopathology of tissues were investigated in the study. Results: Allolobophora caliginosa coelomic fluid significantly decreased urea, creatinine, uric acid, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and malondialdehyde levels while significantly increasing levels of total proteins, albumin, glutathione and catalase. The histopathological investigation showed partial restoration of renal and hepatic architecture. Conclusions: This study shows the potency of Allolobophora caliginosa coelomic fluid in improving the biochemical and histopathological changes induced by gentamicin in the liver and kidney of the rats.