Human Trypanosoma cruzi infection is driven by eco-social interactions in rural communities of the Argentine Chaco.
The transmission of Trypanosoma cruzi to humans is determined by multiple ecological, socio-economic and cultural factors acting at different scales. Their effects on human infection with T. cruzi have often been examined separately or using a limited set of ecological and socio-demographic variable...
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ftdoajarticles:oai:doaj.org/article:b1812440f4654cf6a4a2f229c1f2b09c 2023-05-15T15:15:44+02:00 Human Trypanosoma cruzi infection is driven by eco-social interactions in rural communities of the Argentine Chaco. Maria Del Pilar Fernández Maria Sol Gaspe Paula Sartor Ricardo E Gürtler 2019-12-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007430 https://doaj.org/article/b1812440f4654cf6a4a2f229c1f2b09c EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0007430 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007430 https://doaj.org/article/b1812440f4654cf6a4a2f229c1f2b09c PLoS Neglected Tropical Diseases, Vol 13, Iss 12, p e0007430 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007430 2022-12-31T15:17:04Z The transmission of Trypanosoma cruzi to humans is determined by multiple ecological, socio-economic and cultural factors acting at different scales. Their effects on human infection with T. cruzi have often been examined separately or using a limited set of ecological and socio-demographic variables. Herein, we integrated the ecological and social dimensions of human infection risk with the spatial distribution patterns of human and vector (Triatoma infestans) infection in rural communities of the Argentine Chaco composed of indigenous people (90% Qom) and a creole minority. We conducted serosurveys in 470 households aiming at complete population enumeration over 2012-2015. The estimated seroprevalence of T. cruzi prior to the implementation of an insecticide spraying campaign (2008) was 29.0% (N = 1,373 in 301 households), and was twice as large in Qom than creoles. Using generalized linear mixed models, human seropositive cases significantly increased with infected triatomine abundance, having a seropositive household co-inhabitant and household social vulnerability (a multidimensional index of poverty), and significantly decreased with increasing host availability in sleeping quarters (an index summarizing the number of domestic hosts for T. infestans). Vulnerable household residents were exposed to a higher risk of infection even at low infected-vector abundances. The risk of being seropositive increased significantly with house infestation among children from stable households, whereas both variables were not significantly associated among children from households exhibiting high mobility within the communities, possibly owing to less consistent exposures. Human infection was clustered by household and at a larger spatial scale, with hotspots of human and vector infection matching areas of higher social vulnerability. These results were integrated in a risk map that shows high-priority areas for targeted interventions oriented to suppress house (re)infestations, detect and treat infected children, and thus ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Argentine Chaco ENVELOPE(-60.583,-60.583,-63.033,-63.033) PLOS Neglected Tropical Diseases 13 12 e0007430 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Maria Del Pilar Fernández Maria Sol Gaspe Paula Sartor Ricardo E Gürtler Human Trypanosoma cruzi infection is driven by eco-social interactions in rural communities of the Argentine Chaco. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The transmission of Trypanosoma cruzi to humans is determined by multiple ecological, socio-economic and cultural factors acting at different scales. Their effects on human infection with T. cruzi have often been examined separately or using a limited set of ecological and socio-demographic variables. Herein, we integrated the ecological and social dimensions of human infection risk with the spatial distribution patterns of human and vector (Triatoma infestans) infection in rural communities of the Argentine Chaco composed of indigenous people (90% Qom) and a creole minority. We conducted serosurveys in 470 households aiming at complete population enumeration over 2012-2015. The estimated seroprevalence of T. cruzi prior to the implementation of an insecticide spraying campaign (2008) was 29.0% (N = 1,373 in 301 households), and was twice as large in Qom than creoles. Using generalized linear mixed models, human seropositive cases significantly increased with infected triatomine abundance, having a seropositive household co-inhabitant and household social vulnerability (a multidimensional index of poverty), and significantly decreased with increasing host availability in sleeping quarters (an index summarizing the number of domestic hosts for T. infestans). Vulnerable household residents were exposed to a higher risk of infection even at low infected-vector abundances. The risk of being seropositive increased significantly with house infestation among children from stable households, whereas both variables were not significantly associated among children from households exhibiting high mobility within the communities, possibly owing to less consistent exposures. Human infection was clustered by household and at a larger spatial scale, with hotspots of human and vector infection matching areas of higher social vulnerability. These results were integrated in a risk map that shows high-priority areas for targeted interventions oriented to suppress house (re)infestations, detect and treat infected children, and thus ... |
format |
Article in Journal/Newspaper |
author |
Maria Del Pilar Fernández Maria Sol Gaspe Paula Sartor Ricardo E Gürtler |
author_facet |
Maria Del Pilar Fernández Maria Sol Gaspe Paula Sartor Ricardo E Gürtler |
author_sort |
Maria Del Pilar Fernández |
title |
Human Trypanosoma cruzi infection is driven by eco-social interactions in rural communities of the Argentine Chaco. |
title_short |
Human Trypanosoma cruzi infection is driven by eco-social interactions in rural communities of the Argentine Chaco. |
title_full |
Human Trypanosoma cruzi infection is driven by eco-social interactions in rural communities of the Argentine Chaco. |
title_fullStr |
Human Trypanosoma cruzi infection is driven by eco-social interactions in rural communities of the Argentine Chaco. |
title_full_unstemmed |
Human Trypanosoma cruzi infection is driven by eco-social interactions in rural communities of the Argentine Chaco. |
title_sort |
human trypanosoma cruzi infection is driven by eco-social interactions in rural communities of the argentine chaco. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0007430 https://doaj.org/article/b1812440f4654cf6a4a2f229c1f2b09c |
long_lat |
ENVELOPE(-60.583,-60.583,-63.033,-63.033) |
geographic |
Arctic Argentine Chaco |
geographic_facet |
Arctic Argentine Chaco |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 12, p e0007430 (2019) |
op_relation |
https://doi.org/10.1371/journal.pntd.0007430 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007430 https://doaj.org/article/b1812440f4654cf6a4a2f229c1f2b09c |
op_doi |
https://doi.org/10.1371/journal.pntd.0007430 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
13 |
container_issue |
12 |
container_start_page |
e0007430 |
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1766346078909628416 |