Gamma Aminobutyric Acid-Enriched Fermented Oyster ( Crassostrea gigas ) Increases the Length of the Growth Plate on the Proximal Tibia Bone in Sprague-Dawley Rats

Bone growth during childhood and puberty determines an adult’s final stature. Although several prior studies have reported that fermented oyster (FO) consisting of a high amount of gamma aminobutyric acid can be attributed to bone health, there is no research on the efficacy of FO on growth regulati...

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Bibliographic Details
Published in:Molecules
Main Authors: Hyesook Lee, Hyun Hwangbo, Seon Yeong Ji, Min Yeong Kim, So Young Kim, Da Hye Kim, Su Hyun Hong, Su Jeong Lee, Freshet Assefa, Gi-Young Kim, Eui Kyun Park, Joung-Hyun Park, Bae-Jin Lee, You-Jin Jeon, Yung Hyun Choi
Format: Article in Journal/Newspaper
Language:English
Published: MDPI AG 2020
Subjects:
fermented oyster
gamma aminobutyric acid
insulin like growth factor-1
recombinant human growth hormone
tibial growth plate
Organic chemistry
QD241-441
Crassostrea gigas
Online Access:https://doi.org/10.3390/molecules25194375
https://doaj.org/article/b17501da11954d40a4a3dfabf0881595
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Summary:Bone growth during childhood and puberty determines an adult’s final stature. Although several prior studies have reported that fermented oyster (FO) consisting of a high amount of gamma aminobutyric acid can be attributed to bone health, there is no research on the efficacy of FO on growth regulation and the proximal tibial growth plate. Therefore, in this study, we investigated the effect of FO oral administration on hepatic and serum growth regulator levels and the development of the proximal tibial growth plate in young Sprague-Dawley rats. Both oral administration of FO (FO 100, 100 mg/kg FO and FO 200, 200 mg/kg FO) and subcutaneous injection of recombinant human growth hormone (rhGH, 200 μg/kg of rhGH) for two weeks showed no toxicity. Circulating levels of growth hormone (GH) significantly increased in the FO 200 group. The expression and secretion of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) were enhanced by FO administration. FO administration promoted the expression of bone morphogenic proteins IGF-1 and IGFBP-3 in the proximal tibial growth plate. This positive effect of FO resulted in incremental growth of the entire plate length by expanding the proliferating and hypertrophic zones in the proximal tibial growth plate. Collectively, our results suggested that oral administration of FO is beneficial for bone health, which may ultimately result in increased height.

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