Cryoglobulinemia in chronic hepatitis C: clinical aspects and response to treatment with interferon alpha and ribavirin Crioglobulinemia na hepatite crônica C: aspectos clínicos e resposta ao tratamento com interferon alfa e ribavirina
INTRODUCTION: The main extra-hepatic manifestation of hepatitis C is mixed cryoglobulinemia (MC). The aim of this study was to evaluate its prevalence among patients with chronic hepatitis C (CHC), to correlate its presence to host and virological variables and to the response to combined therapy wi...
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ftdoajarticles:oai:doaj.org/article:b14cc09afa6b48168fd9ccdc5bfa9942 2024-09-09T19:28:26+00:00 Cryoglobulinemia in chronic hepatitis C: clinical aspects and response to treatment with interferon alpha and ribavirin Crioglobulinemia na hepatite crônica C: aspectos clínicos e resposta ao tratamento com interferon alfa e ribavirina Edison Roberto Parise Ana Cláudia de Oliveira Maria Lúcia Ferraz Aparecido Bernardo Pereira Kátia Ramos Leite 2007-04-01T00:00:00Z https://doi.org/10.1590/S0036-46652007000200001 https://doaj.org/article/b14cc09afa6b48168fd9ccdc5bfa9942 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652007000200001 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46652007000200001 0036-4665 1678-9946 https://doaj.org/article/b14cc09afa6b48168fd9ccdc5bfa9942 Revista do Instituto de Medicina Tropical de São Paulo, Vol 49, Iss 2, Pp 67-72 (2007) Mixed cryoglobulinemia Chronic hepatitis C Interferon and ribavirin Cirrhosis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2007 ftdoajarticles https://doi.org/10.1590/S0036-46652007000200001 2024-08-05T17:49:30Z INTRODUCTION: The main extra-hepatic manifestation of hepatitis C is mixed cryoglobulinemia (MC). The aim of this study was to evaluate its prevalence among patients with chronic hepatitis C (CHC), to correlate its presence to host and virological variables and to the response to combined therapy with interferon-alpha and ribavirin. CASUISTIC AND METHODS: 202 CHC naive patients (136 with chronic hepatitis and 66 with cirrhosis) were consecutively evaluated for the presence of cryoglobulins. Cryoprecipitates were characterized by immunoelectrophoresis and classified according to the Brouet's criteria. RESULTS: The prevalence of MC was 27% (54/202), and 24% of them (13/54) showed major clinical manifestation of the disease. Even though type III MC was more frequent (78%), symptomatic MC was more common in type II MC. The presence of cirrhosis (RR = 2.073; IC95% = 1.029 - 4.179; p = 0.041), and age of the patients (RR = 1.035; IC95% = 1.008 - 1.062; p = 0.01) were independently associated with the presence of cryoglobulins. No relationship was found with viral load and genotype. 102 patients were treated with interferon alpha and ribavirin. Among these, 31 had MC. Sustained virological response (around 30%) was similar in patients with and without MC (p = 0.971). CONCLUSION: MC represents a prevalent complication in patients with CHC, specially older and cirrhotic patients. Only 24% of these patients show clinical manifestation of the disease, specially those with type II MC. The presence of MC did not affect the response to therapy. INTRODUÇÃO: A crioglobulinemia mista (CM) representa importante complicação extra-hepática da hepatite C. Nesse estudo avaliamos sua prevelência em pacientes com hepatite C crônica (HCC) e relacionamos sua presença com aspectos clínicos e resposta ao tratamento com interferon alfa e ribavirina. CASUÍSTICA E MÉTODOS: 202 pacientes consecutivos com HCC (136 com hepatite crônica e 66 com cirrose) foram avaliados para a presença de CM. Os crioprecipitados foram caracterizados por ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 49 2 67 72 |
institution |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Mixed cryoglobulinemia Chronic hepatitis C Interferon and ribavirin Cirrhosis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Mixed cryoglobulinemia Chronic hepatitis C Interferon and ribavirin Cirrhosis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Edison Roberto Parise Ana Cláudia de Oliveira Maria Lúcia Ferraz Aparecido Bernardo Pereira Kátia Ramos Leite Cryoglobulinemia in chronic hepatitis C: clinical aspects and response to treatment with interferon alpha and ribavirin Crioglobulinemia na hepatite crônica C: aspectos clínicos e resposta ao tratamento com interferon alfa e ribavirina |
topic_facet |
Mixed cryoglobulinemia Chronic hepatitis C Interferon and ribavirin Cirrhosis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
INTRODUCTION: The main extra-hepatic manifestation of hepatitis C is mixed cryoglobulinemia (MC). The aim of this study was to evaluate its prevalence among patients with chronic hepatitis C (CHC), to correlate its presence to host and virological variables and to the response to combined therapy with interferon-alpha and ribavirin. CASUISTIC AND METHODS: 202 CHC naive patients (136 with chronic hepatitis and 66 with cirrhosis) were consecutively evaluated for the presence of cryoglobulins. Cryoprecipitates were characterized by immunoelectrophoresis and classified according to the Brouet's criteria. RESULTS: The prevalence of MC was 27% (54/202), and 24% of them (13/54) showed major clinical manifestation of the disease. Even though type III MC was more frequent (78%), symptomatic MC was more common in type II MC. The presence of cirrhosis (RR = 2.073; IC95% = 1.029 - 4.179; p = 0.041), and age of the patients (RR = 1.035; IC95% = 1.008 - 1.062; p = 0.01) were independently associated with the presence of cryoglobulins. No relationship was found with viral load and genotype. 102 patients were treated with interferon alpha and ribavirin. Among these, 31 had MC. Sustained virological response (around 30%) was similar in patients with and without MC (p = 0.971). CONCLUSION: MC represents a prevalent complication in patients with CHC, specially older and cirrhotic patients. Only 24% of these patients show clinical manifestation of the disease, specially those with type II MC. The presence of MC did not affect the response to therapy. INTRODUÇÃO: A crioglobulinemia mista (CM) representa importante complicação extra-hepática da hepatite C. Nesse estudo avaliamos sua prevelência em pacientes com hepatite C crônica (HCC) e relacionamos sua presença com aspectos clínicos e resposta ao tratamento com interferon alfa e ribavirina. CASUÍSTICA E MÉTODOS: 202 pacientes consecutivos com HCC (136 com hepatite crônica e 66 com cirrose) foram avaliados para a presença de CM. Os crioprecipitados foram caracterizados por ... |
format |
Article in Journal/Newspaper |
author |
Edison Roberto Parise Ana Cláudia de Oliveira Maria Lúcia Ferraz Aparecido Bernardo Pereira Kátia Ramos Leite |
author_facet |
Edison Roberto Parise Ana Cláudia de Oliveira Maria Lúcia Ferraz Aparecido Bernardo Pereira Kátia Ramos Leite |
author_sort |
Edison Roberto Parise |
title |
Cryoglobulinemia in chronic hepatitis C: clinical aspects and response to treatment with interferon alpha and ribavirin Crioglobulinemia na hepatite crônica C: aspectos clínicos e resposta ao tratamento com interferon alfa e ribavirina |
title_short |
Cryoglobulinemia in chronic hepatitis C: clinical aspects and response to treatment with interferon alpha and ribavirin Crioglobulinemia na hepatite crônica C: aspectos clínicos e resposta ao tratamento com interferon alfa e ribavirina |
title_full |
Cryoglobulinemia in chronic hepatitis C: clinical aspects and response to treatment with interferon alpha and ribavirin Crioglobulinemia na hepatite crônica C: aspectos clínicos e resposta ao tratamento com interferon alfa e ribavirina |
title_fullStr |
Cryoglobulinemia in chronic hepatitis C: clinical aspects and response to treatment with interferon alpha and ribavirin Crioglobulinemia na hepatite crônica C: aspectos clínicos e resposta ao tratamento com interferon alfa e ribavirina |
title_full_unstemmed |
Cryoglobulinemia in chronic hepatitis C: clinical aspects and response to treatment with interferon alpha and ribavirin Crioglobulinemia na hepatite crônica C: aspectos clínicos e resposta ao tratamento com interferon alfa e ribavirina |
title_sort |
cryoglobulinemia in chronic hepatitis c: clinical aspects and response to treatment with interferon alpha and ribavirin crioglobulinemia na hepatite crônica c: aspectos clínicos e resposta ao tratamento com interferon alfa e ribavirina |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2007 |
url |
https://doi.org/10.1590/S0036-46652007000200001 https://doaj.org/article/b14cc09afa6b48168fd9ccdc5bfa9942 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 49, Iss 2, Pp 67-72 (2007) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652007000200001 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46652007000200001 0036-4665 1678-9946 https://doaj.org/article/b14cc09afa6b48168fd9ccdc5bfa9942 |
op_doi |
https://doi.org/10.1590/S0036-46652007000200001 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
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49 |
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2 |
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67 |
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72 |
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