Association of FOXP3 gene -3279 C>A polymorphism with the risk of pulmonary sarcoidosis
Aim. To investigate the association of the polymorphic marker -3279 C>A of the FOXP3 gene with the risk of pulmonary sarcoidosis (PS) and to estimate the transcription level of this gene in the carriers of different genotypes of this polymorphic marker. Subjects and methods. The investigation inc...
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ftdoajarticles:oai:doaj.org/article:b12f65581e334ccb8ca3aaab141cdf87 2023-05-15T18:06:28+02:00 Association of FOXP3 gene -3279 C>A polymorphism with the risk of pulmonary sarcoidosis I E Malysheva L V Topchieva E L Tikhonovich I V Kurbatova O V Balan 2017-12-01T00:00:00Z https://doi.org/10.17116/terarkh2017891264-67 https://doaj.org/article/b12f65581e334ccb8ca3aaab141cdf87 RU rus "Consilium Medicum" Publishing house https://ter-arkhiv.ru/0040-3660/article/view/32332 https://doaj.org/toc/0040-3660 https://doaj.org/toc/2309-5342 0040-3660 2309-5342 doi:10.17116/terarkh2017891264-67 https://doaj.org/article/b12f65581e334ccb8ca3aaab141cdf87 Терапевтический архив, Vol 89, Iss 12, Pp 64-67 (2017) pulmonary sarcoidosis foxp3 gene polymorphism expression Medicine R article 2017 ftdoajarticles https://doi.org/10.17116/terarkh2017891264-67 2022-12-31T08:56:22Z Aim. To investigate the association of the polymorphic marker -3279 C>A of the FOXP3 gene with the risk of pulmonary sarcoidosis (PS) and to estimate the transcription level of this gene in the carriers of different genotypes of this polymorphic marker. Subjects and methods. The investigation included 99 patients of Russian ethnicity (mean age, 45.41±1.31 years) living in the Republic of Karelia, who were diagnosed with persistent PS, and 116 healthy donors (mean age, 42.06±1.30 years) in the control group. The alleles and genotypes of the polymorphic marker -3279 C>A of the FOXP3 gene were identified using polymerase chain reaction (PCR)-restriction fragment length polymorphism. The number of transcripts of the studied gene in the peripheral blood leukocytes of healthy donors and PS patients was determined with real-time PCR. Results. The control group and the PS patient one had no statistically significant differences in the distribution of the frequencies of alleles and genotypes by the polymorphic marker –308G>A of the FOXP3 gene (p > 0.05). The number of FOXP3 gene transcripts was not statistically significantly different in the peripheral blood leukocytes of patients with PS and control individuals. No statistically significant differences were observed in the mRNA expression levels in the above-mentioned gene in the carriers of different genotypes by the polymorphic marker -3279 C>A of the FOXP3 gene in all examined groups. Conclusion. The polymorphic marker -3279 C>A of the FOXP3 gene is unassociated with the risk of PS. Article in Journal/Newspaper Republic of Karelia Directory of Open Access Journals: DOAJ Articles Terapevticheskii arkhiv 89 12 64 67 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
Russian |
topic |
pulmonary sarcoidosis foxp3 gene polymorphism expression Medicine R |
spellingShingle |
pulmonary sarcoidosis foxp3 gene polymorphism expression Medicine R I E Malysheva L V Topchieva E L Tikhonovich I V Kurbatova O V Balan Association of FOXP3 gene -3279 C>A polymorphism with the risk of pulmonary sarcoidosis |
topic_facet |
pulmonary sarcoidosis foxp3 gene polymorphism expression Medicine R |
description |
Aim. To investigate the association of the polymorphic marker -3279 C>A of the FOXP3 gene with the risk of pulmonary sarcoidosis (PS) and to estimate the transcription level of this gene in the carriers of different genotypes of this polymorphic marker. Subjects and methods. The investigation included 99 patients of Russian ethnicity (mean age, 45.41±1.31 years) living in the Republic of Karelia, who were diagnosed with persistent PS, and 116 healthy donors (mean age, 42.06±1.30 years) in the control group. The alleles and genotypes of the polymorphic marker -3279 C>A of the FOXP3 gene were identified using polymerase chain reaction (PCR)-restriction fragment length polymorphism. The number of transcripts of the studied gene in the peripheral blood leukocytes of healthy donors and PS patients was determined with real-time PCR. Results. The control group and the PS patient one had no statistically significant differences in the distribution of the frequencies of alleles and genotypes by the polymorphic marker –308G>A of the FOXP3 gene (p > 0.05). The number of FOXP3 gene transcripts was not statistically significantly different in the peripheral blood leukocytes of patients with PS and control individuals. No statistically significant differences were observed in the mRNA expression levels in the above-mentioned gene in the carriers of different genotypes by the polymorphic marker -3279 C>A of the FOXP3 gene in all examined groups. Conclusion. The polymorphic marker -3279 C>A of the FOXP3 gene is unassociated with the risk of PS. |
format |
Article in Journal/Newspaper |
author |
I E Malysheva L V Topchieva E L Tikhonovich I V Kurbatova O V Balan |
author_facet |
I E Malysheva L V Topchieva E L Tikhonovich I V Kurbatova O V Balan |
author_sort |
I E Malysheva |
title |
Association of FOXP3 gene -3279 C>A polymorphism with the risk of pulmonary sarcoidosis |
title_short |
Association of FOXP3 gene -3279 C>A polymorphism with the risk of pulmonary sarcoidosis |
title_full |
Association of FOXP3 gene -3279 C>A polymorphism with the risk of pulmonary sarcoidosis |
title_fullStr |
Association of FOXP3 gene -3279 C>A polymorphism with the risk of pulmonary sarcoidosis |
title_full_unstemmed |
Association of FOXP3 gene -3279 C>A polymorphism with the risk of pulmonary sarcoidosis |
title_sort |
association of foxp3 gene -3279 c>a polymorphism with the risk of pulmonary sarcoidosis |
publisher |
"Consilium Medicum" Publishing house |
publishDate |
2017 |
url |
https://doi.org/10.17116/terarkh2017891264-67 https://doaj.org/article/b12f65581e334ccb8ca3aaab141cdf87 |
genre |
Republic of Karelia |
genre_facet |
Republic of Karelia |
op_source |
Терапевтический архив, Vol 89, Iss 12, Pp 64-67 (2017) |
op_relation |
https://ter-arkhiv.ru/0040-3660/article/view/32332 https://doaj.org/toc/0040-3660 https://doaj.org/toc/2309-5342 0040-3660 2309-5342 doi:10.17116/terarkh2017891264-67 https://doaj.org/article/b12f65581e334ccb8ca3aaab141cdf87 |
op_doi |
https://doi.org/10.17116/terarkh2017891264-67 |
container_title |
Terapevticheskii arkhiv |
container_volume |
89 |
container_issue |
12 |
container_start_page |
64 |
op_container_end_page |
67 |
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1766178106789330944 |