Modelling dynamic change of malaria transmission in holoendemic setting (Dielmo, Senegal) using longitudinal measures of antibody prevalence to Plasmodium falciparum crude schizonts extract
Abstract Background Evaluation of local Plasmodium falciparum malaria transmission has been investigated previously using the reversible catalytic model based on prevalence of antibody responses to single antigen to estimate seroconversion rates. High correlations were observed between seroconversio...
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ftdoajarticles:oai:doaj.org/article:b11f1decf35c4af896a34286b37889a1 2023-05-15T15:16:31+02:00 Modelling dynamic change of malaria transmission in holoendemic setting (Dielmo, Senegal) using longitudinal measures of antibody prevalence to Plasmodium falciparum crude schizonts extract Oumy Niass Philippe Saint-Pierre Makhtar Niang Fode Diop Babacar Diouf Michel Matar Faye Fatoumata Diène Sarr Joseph Faye Nafissatou Diagne Cheikh Sokhna Jean-François Trape Ronald Perraut Adama Tall Abdou Kâ Diongue Aïssatou Toure Balde 2017-10-01T00:00:00Z https://doi.org/10.1186/s12936-017-2052-0 https://doaj.org/article/b11f1decf35c4af896a34286b37889a1 EN eng BMC http://link.springer.com/article/10.1186/s12936-017-2052-0 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-017-2052-0 1475-2875 https://doaj.org/article/b11f1decf35c4af896a34286b37889a1 Malaria Journal, Vol 16, Iss 1, Pp 1-12 (2017) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2017 ftdoajarticles https://doi.org/10.1186/s12936-017-2052-0 2022-12-31T00:19:58Z Abstract Background Evaluation of local Plasmodium falciparum malaria transmission has been investigated previously using the reversible catalytic model based on prevalence of antibody responses to single antigen to estimate seroconversion rates. High correlations were observed between seroconversion rates and entomological inoculation rates (EIR). However, in this model, the effects of malaria control interventions and clinical episodes on serological measurements were not assessed. This study monitors the use of antibody responses to P. falciparum crude extracts for assessing malaria transmission, compares seroconversion rates estimated from longitudinal data to those derived from cross-sectional surveys and investigates the effects of malaria control interventions on these measures in an area of declining malaria transmission. In addition, the validity of this model was evaluated by comparison with the alternative model. Methods Five cross-sectional surveys were carried out at the end of the wet season in Dielmo, a malaria-endemic Senegalese rural area in 2000, 2002, 2008, 2010 and 2012. Antibodies against schizonts crude extract of a local P. falciparum strain adapted to culture (Pf 07/03) were measured by ELISA. Age-specific seroprevalence model was used both for cross-sectional surveys and longitudinal data (combined data of all surveys). Results A total of 1504 plasma samples obtained through several years follow-up of 350 subjects was used in this study. Seroconversion rates based on P. falciparum schizonts crude extract were estimated for each cross-sectional survey and were found strongly correlated with EIR. High variability between SCRs from cross-sectional and longitudinal surveys was observed. In longitudinal studies, the alternative catalytic reversible model adjusted better with serological data than the catalytic model. Clinical malaria attacks and malaria control interventions were found to have significant effect on seroconversion. Discussion The results of the study suggested that crude ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 16 1 |
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Directory of Open Access Journals: DOAJ Articles |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Oumy Niass Philippe Saint-Pierre Makhtar Niang Fode Diop Babacar Diouf Michel Matar Faye Fatoumata Diène Sarr Joseph Faye Nafissatou Diagne Cheikh Sokhna Jean-François Trape Ronald Perraut Adama Tall Abdou Kâ Diongue Aïssatou Toure Balde Modelling dynamic change of malaria transmission in holoendemic setting (Dielmo, Senegal) using longitudinal measures of antibody prevalence to Plasmodium falciparum crude schizonts extract |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Evaluation of local Plasmodium falciparum malaria transmission has been investigated previously using the reversible catalytic model based on prevalence of antibody responses to single antigen to estimate seroconversion rates. High correlations were observed between seroconversion rates and entomological inoculation rates (EIR). However, in this model, the effects of malaria control interventions and clinical episodes on serological measurements were not assessed. This study monitors the use of antibody responses to P. falciparum crude extracts for assessing malaria transmission, compares seroconversion rates estimated from longitudinal data to those derived from cross-sectional surveys and investigates the effects of malaria control interventions on these measures in an area of declining malaria transmission. In addition, the validity of this model was evaluated by comparison with the alternative model. Methods Five cross-sectional surveys were carried out at the end of the wet season in Dielmo, a malaria-endemic Senegalese rural area in 2000, 2002, 2008, 2010 and 2012. Antibodies against schizonts crude extract of a local P. falciparum strain adapted to culture (Pf 07/03) were measured by ELISA. Age-specific seroprevalence model was used both for cross-sectional surveys and longitudinal data (combined data of all surveys). Results A total of 1504 plasma samples obtained through several years follow-up of 350 subjects was used in this study. Seroconversion rates based on P. falciparum schizonts crude extract were estimated for each cross-sectional survey and were found strongly correlated with EIR. High variability between SCRs from cross-sectional and longitudinal surveys was observed. In longitudinal studies, the alternative catalytic reversible model adjusted better with serological data than the catalytic model. Clinical malaria attacks and malaria control interventions were found to have significant effect on seroconversion. Discussion The results of the study suggested that crude ... |
format |
Article in Journal/Newspaper |
author |
Oumy Niass Philippe Saint-Pierre Makhtar Niang Fode Diop Babacar Diouf Michel Matar Faye Fatoumata Diène Sarr Joseph Faye Nafissatou Diagne Cheikh Sokhna Jean-François Trape Ronald Perraut Adama Tall Abdou Kâ Diongue Aïssatou Toure Balde |
author_facet |
Oumy Niass Philippe Saint-Pierre Makhtar Niang Fode Diop Babacar Diouf Michel Matar Faye Fatoumata Diène Sarr Joseph Faye Nafissatou Diagne Cheikh Sokhna Jean-François Trape Ronald Perraut Adama Tall Abdou Kâ Diongue Aïssatou Toure Balde |
author_sort |
Oumy Niass |
title |
Modelling dynamic change of malaria transmission in holoendemic setting (Dielmo, Senegal) using longitudinal measures of antibody prevalence to Plasmodium falciparum crude schizonts extract |
title_short |
Modelling dynamic change of malaria transmission in holoendemic setting (Dielmo, Senegal) using longitudinal measures of antibody prevalence to Plasmodium falciparum crude schizonts extract |
title_full |
Modelling dynamic change of malaria transmission in holoendemic setting (Dielmo, Senegal) using longitudinal measures of antibody prevalence to Plasmodium falciparum crude schizonts extract |
title_fullStr |
Modelling dynamic change of malaria transmission in holoendemic setting (Dielmo, Senegal) using longitudinal measures of antibody prevalence to Plasmodium falciparum crude schizonts extract |
title_full_unstemmed |
Modelling dynamic change of malaria transmission in holoendemic setting (Dielmo, Senegal) using longitudinal measures of antibody prevalence to Plasmodium falciparum crude schizonts extract |
title_sort |
modelling dynamic change of malaria transmission in holoendemic setting (dielmo, senegal) using longitudinal measures of antibody prevalence to plasmodium falciparum crude schizonts extract |
publisher |
BMC |
publishDate |
2017 |
url |
https://doi.org/10.1186/s12936-017-2052-0 https://doaj.org/article/b11f1decf35c4af896a34286b37889a1 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 16, Iss 1, Pp 1-12 (2017) |
op_relation |
http://link.springer.com/article/10.1186/s12936-017-2052-0 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-017-2052-0 1475-2875 https://doaj.org/article/b11f1decf35c4af896a34286b37889a1 |
op_doi |
https://doi.org/10.1186/s12936-017-2052-0 |
container_title |
Malaria Journal |
container_volume |
16 |
container_issue |
1 |
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1766346809345572864 |