MOLECULAR EPIDEMIOLOGICAL ANALYSIS OF HIV INFECTION IN NORTHERN SEAPORTS OF RUSSIA

• Published in: Problems of Virology
• Main Authors: E. V. Kazennova, V. Yu. Laga, K. B. Gromov, M. N. Sankov, E. S. Popova, E. G. Lgumnova, E. N. Oparina, T. A. Sorokina, M. R. Bobkova
• Format: Article in Journal/Newspaper
• Language: English; Russian
• Published: Central Research Institute for Epidemiology 2017
• Subjects: hiv-1; subtype; phylogenetic analysis; Microbiology; QR1-502; Murmansk; Arkhangelsk
• Online Access: https://doi.org/10.18821/0507-4088-2017-62-4-154-161; https://doaj.org/article/b0ce38d9e65343988c2dd78f41697a3a

The results of the molecular-epidemiological analysis of HIV-1 variants circulating in Arkhangelsk and Murmansk - northern seaports of Russia - were presented. In these seaports the HIV-1 variants belonging to subtype A1 were predominant (93% in Murmansk, 83% in Arkhangelsk). In addition to these variants, viruses of other subtypes such as B, C, D and recombinant forms CRF02_AG and CRF03_AB were identified. The heterogeneity of circulating HIV-1 variants was higher in Arkhangelsk than in Murmansk. According to the results of phylogenetic analysis, subtype A1 sequences formed the common branch with nucleotide sequences of IDU-A strains found in other regions of Russia. HIV-1 variants of subtype B sub-clustered with sequences of East European B-variants. The recombinant strains CRF02_AG formed the common branch with HIV-1 sequences from Central Asia republics of the former USSR. Among 124 therapy-naive patients from Arkhangelsk and Murmansk (n = 124) the transmitted resistance was less than 5%.