Pharmacological effects of ethanol extract of Egyptian Artemisia herba-alba in rats and mice
Objective: To investigate some pharmacological effects including gastroprotective, anti-inflammatory, analgesic, antipyretic and in vitro antioxidant effects of Artemisia herba-alba extract in different experimental models. Methods: Inflammation was induced in rat paw by subcutaneous injection of 1%...
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Wolters Kluwer Medknow Publications
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ftdoajarticles:oai:doaj.org/article:b0abaea603f5499d9447cdd37f8c0a32 2023-05-15T15:06:23+02:00 Pharmacological effects of ethanol extract of Egyptian Artemisia herba-alba in rats and mice Gehad Abdel Raheem Abdel Jaleel Heba Mohammed Ibrahim Abdallah Nawal E.L. Sayed Gomaa 2016-01-01T00:00:00Z https://doi.org/10.1016/j.apjtb.2015.10.005 https://doaj.org/article/b0abaea603f5499d9447cdd37f8c0a32 EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169115002518 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2015.10.005 https://doaj.org/article/b0abaea603f5499d9447cdd37f8c0a32 Asian Pacific Journal of Tropical Biomedicine, Vol 6, Iss 1, Pp 44-49 (2016) Artemisia herba-alba Gastric ulcer Inflammation Antioxidant Rats Mice Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2016 ftdoajarticles https://doi.org/10.1016/j.apjtb.2015.10.005 2022-12-31T06:53:23Z Objective: To investigate some pharmacological effects including gastroprotective, anti-inflammatory, analgesic, antipyretic and in vitro antioxidant effects of Artemisia herba-alba extract in different experimental models. Methods: Inflammation was induced in rat paw by subcutaneous injection of 1% (v/v) carrageenan solution. Writhes was induced in mice by intraperitoneal injection of 0.6% (v/v) acetic acid solution. Pyrexia was induced using Brewer's yeast suspension. Gastric lesion was induced in rats by oral administration of 99% ethanol. The anti-inflammatory, analgesic, antipyretic and gastroprotective activities of Artemisia herba-alba extract were investigated respectively. In vitro antioxidant effect was investigated using DPPH free radical. Results: The plant extract showed anti-inflammatory effect in carrageenan-induced paw edema in rats, analgesic effect against acetic acid-induced writhing, and antipyretic activity in Brewer's yeast model of pyrexia. Besides, it was shown to be a gastroprotective agent against ethanol-induced gastric ulcers. The plant also exhibited a free radical scavenging potential in an in vitro antioxidant study using DPPH. Conclusions: The results validate the use of the investigated plant in traditional medicine for different ailments. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 6 1 44 49 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Artemisia herba-alba Gastric ulcer Inflammation Antioxidant Rats Mice Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Artemisia herba-alba Gastric ulcer Inflammation Antioxidant Rats Mice Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Gehad Abdel Raheem Abdel Jaleel Heba Mohammed Ibrahim Abdallah Nawal E.L. Sayed Gomaa Pharmacological effects of ethanol extract of Egyptian Artemisia herba-alba in rats and mice |
topic_facet |
Artemisia herba-alba Gastric ulcer Inflammation Antioxidant Rats Mice Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To investigate some pharmacological effects including gastroprotective, anti-inflammatory, analgesic, antipyretic and in vitro antioxidant effects of Artemisia herba-alba extract in different experimental models. Methods: Inflammation was induced in rat paw by subcutaneous injection of 1% (v/v) carrageenan solution. Writhes was induced in mice by intraperitoneal injection of 0.6% (v/v) acetic acid solution. Pyrexia was induced using Brewer's yeast suspension. Gastric lesion was induced in rats by oral administration of 99% ethanol. The anti-inflammatory, analgesic, antipyretic and gastroprotective activities of Artemisia herba-alba extract were investigated respectively. In vitro antioxidant effect was investigated using DPPH free radical. Results: The plant extract showed anti-inflammatory effect in carrageenan-induced paw edema in rats, analgesic effect against acetic acid-induced writhing, and antipyretic activity in Brewer's yeast model of pyrexia. Besides, it was shown to be a gastroprotective agent against ethanol-induced gastric ulcers. The plant also exhibited a free radical scavenging potential in an in vitro antioxidant study using DPPH. Conclusions: The results validate the use of the investigated plant in traditional medicine for different ailments. |
format |
Article in Journal/Newspaper |
author |
Gehad Abdel Raheem Abdel Jaleel Heba Mohammed Ibrahim Abdallah Nawal E.L. Sayed Gomaa |
author_facet |
Gehad Abdel Raheem Abdel Jaleel Heba Mohammed Ibrahim Abdallah Nawal E.L. Sayed Gomaa |
author_sort |
Gehad Abdel Raheem Abdel Jaleel |
title |
Pharmacological effects of ethanol extract of Egyptian Artemisia herba-alba in rats and mice |
title_short |
Pharmacological effects of ethanol extract of Egyptian Artemisia herba-alba in rats and mice |
title_full |
Pharmacological effects of ethanol extract of Egyptian Artemisia herba-alba in rats and mice |
title_fullStr |
Pharmacological effects of ethanol extract of Egyptian Artemisia herba-alba in rats and mice |
title_full_unstemmed |
Pharmacological effects of ethanol extract of Egyptian Artemisia herba-alba in rats and mice |
title_sort |
pharmacological effects of ethanol extract of egyptian artemisia herba-alba in rats and mice |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2016 |
url |
https://doi.org/10.1016/j.apjtb.2015.10.005 https://doaj.org/article/b0abaea603f5499d9447cdd37f8c0a32 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 6, Iss 1, Pp 44-49 (2016) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169115002518 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2015.10.005 https://doaj.org/article/b0abaea603f5499d9447cdd37f8c0a32 |
op_doi |
https://doi.org/10.1016/j.apjtb.2015.10.005 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
6 |
container_issue |
1 |
container_start_page |
44 |
op_container_end_page |
49 |
_version_ |
1766338007677272064 |