The safety and immunogenicity of a cell-derived adjuvanted H5N1 vaccine – A phase I randomized clinical trial

• Published in: Journal of Microbiology, Immunology and Infection
• Main Authors: Aristine Cheng, Szu-Min Hsieh, Sung-Ching Pan, Yu-Han Li, Erh-Fang Hsieh, Hsiang-Chi Lee, Ting-Wan Lin, Kuan-Lang Lai, Charles Chen, Stanley Shi-Chung Chang, Shan-Chwen Chang
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier 2019
• Subjects: Microbiology; QR1-502; Darby; Avian flu
• Online Access: https://doi.org/10.1016/j.jmii.2019.03.009; https://doaj.org/article/b0907daaec2e4aae84ad5f05d69fb80a

Background: Development of an efficacious egg-free mock-up H5N1 vaccine is key to our preparedness against pandemic avian flu. Methods: This is a single-center, randomized, observer-blinded phase I clinical trial evaluating the safety and immunogenicity of an alum-adjuvanted Madin–Darby canine kidne...