MONTENEGRO SKIN TEST AND AGE OF SKIN LESION AS PREDICTORS OF TREATMENT FAILURE IN CUTANEOUS LEISHMANIASIS
A case-control study was conducted to examine the association among the Montenegro skin test (MST), age of skin lesion and therapeutic response in patients with cutaneous leishmaniasis (CL) treated at Evandro Chagas National Institute of Infectious Diseases (INI), Oswaldo Cruz Foundation (FIOCRUZ),...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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Universidade de São Paulo (USP)
2014
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Online Access: | https://doi.org/10.1590/S0036-46652014000500002 https://doaj.org/article/b086a46ca94c458088e463b47656754f |
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ftdoajarticles:oai:doaj.org/article:b086a46ca94c458088e463b47656754f 2024-09-09T19:26:10+00:00 MONTENEGRO SKIN TEST AND AGE OF SKIN LESION AS PREDICTORS OF TREATMENT FAILURE IN CUTANEOUS LEISHMANIASIS Liliane de Fátima Antonio Aline Fagundes Raquel Vasconcellos Carvalhaes Oliveira Priscila Garcia Pinto Sandro Javier Bedoya-Pacheco Érica de Camargo Ferreira e Vasconcellos Maria Cláudia Valete-Rosalino Marcelo Rosandiski Lyra Sônia Regina Lambert Passos Maria Inês Fernandes Pimentel Armando de Oliveira Schubach 2014-09-01T00:00:00Z https://doi.org/10.1590/S0036-46652014000500002 https://doaj.org/article/b086a46ca94c458088e463b47656754f EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652014000500375&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/S0036-46652014000500002 https://doaj.org/article/b086a46ca94c458088e463b47656754f Revista do Instituto de Medicina Tropical de São Paulo, Vol 56, Iss 5, Pp 375-380 (2014) Skin tests Cutaneous leishmaniasis Treatment failure Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2014 ftdoajarticles https://doi.org/10.1590/S0036-46652014000500002 2024-08-05T17:49:31Z A case-control study was conducted to examine the association among the Montenegro skin test (MST), age of skin lesion and therapeutic response in patients with cutaneous leishmaniasis (CL) treated at Evandro Chagas National Institute of Infectious Diseases (INI), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil. For each treatment failure (case), two controls showing skin lesion healing following treatment, paired by sex and age, were randomly selected. All patients were treated with 5 mg Sb5+/kg/day of intramuscular meglumine antimoniate (Sb5+) for 30 successive days. Patients with CL were approximately five times more likely to fail when lesions were less than two months old at the first appointment. Patients with treatment failure showed less intense MST reactions than patients progressing to clinical cure. For each 10 mm of increase in MST response, there was a 26% reduction in the chance of treatment failure. An early treatment - defined as a treatment applied for skin lesions, which starts when they are less than two months old at the first appointment -, as well as a poor cellular immune response, reflected by lower reactivity in MST, were associated with treatment failure in cutaneous leishmaniasis. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Evandro ENVELOPE(-65.633,-65.633,-65.400,-65.400) Revista do Instituto de Medicina Tropical de São Paulo 56 5 375 380 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Skin tests Cutaneous leishmaniasis Treatment failure Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Skin tests Cutaneous leishmaniasis Treatment failure Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Liliane de Fátima Antonio Aline Fagundes Raquel Vasconcellos Carvalhaes Oliveira Priscila Garcia Pinto Sandro Javier Bedoya-Pacheco Érica de Camargo Ferreira e Vasconcellos Maria Cláudia Valete-Rosalino Marcelo Rosandiski Lyra Sônia Regina Lambert Passos Maria Inês Fernandes Pimentel Armando de Oliveira Schubach MONTENEGRO SKIN TEST AND AGE OF SKIN LESION AS PREDICTORS OF TREATMENT FAILURE IN CUTANEOUS LEISHMANIASIS |
topic_facet |
Skin tests Cutaneous leishmaniasis Treatment failure Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
A case-control study was conducted to examine the association among the Montenegro skin test (MST), age of skin lesion and therapeutic response in patients with cutaneous leishmaniasis (CL) treated at Evandro Chagas National Institute of Infectious Diseases (INI), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil. For each treatment failure (case), two controls showing skin lesion healing following treatment, paired by sex and age, were randomly selected. All patients were treated with 5 mg Sb5+/kg/day of intramuscular meglumine antimoniate (Sb5+) for 30 successive days. Patients with CL were approximately five times more likely to fail when lesions were less than two months old at the first appointment. Patients with treatment failure showed less intense MST reactions than patients progressing to clinical cure. For each 10 mm of increase in MST response, there was a 26% reduction in the chance of treatment failure. An early treatment - defined as a treatment applied for skin lesions, which starts when they are less than two months old at the first appointment -, as well as a poor cellular immune response, reflected by lower reactivity in MST, were associated with treatment failure in cutaneous leishmaniasis. |
format |
Article in Journal/Newspaper |
author |
Liliane de Fátima Antonio Aline Fagundes Raquel Vasconcellos Carvalhaes Oliveira Priscila Garcia Pinto Sandro Javier Bedoya-Pacheco Érica de Camargo Ferreira e Vasconcellos Maria Cláudia Valete-Rosalino Marcelo Rosandiski Lyra Sônia Regina Lambert Passos Maria Inês Fernandes Pimentel Armando de Oliveira Schubach |
author_facet |
Liliane de Fátima Antonio Aline Fagundes Raquel Vasconcellos Carvalhaes Oliveira Priscila Garcia Pinto Sandro Javier Bedoya-Pacheco Érica de Camargo Ferreira e Vasconcellos Maria Cláudia Valete-Rosalino Marcelo Rosandiski Lyra Sônia Regina Lambert Passos Maria Inês Fernandes Pimentel Armando de Oliveira Schubach |
author_sort |
Liliane de Fátima Antonio |
title |
MONTENEGRO SKIN TEST AND AGE OF SKIN LESION AS PREDICTORS OF TREATMENT FAILURE IN CUTANEOUS LEISHMANIASIS |
title_short |
MONTENEGRO SKIN TEST AND AGE OF SKIN LESION AS PREDICTORS OF TREATMENT FAILURE IN CUTANEOUS LEISHMANIASIS |
title_full |
MONTENEGRO SKIN TEST AND AGE OF SKIN LESION AS PREDICTORS OF TREATMENT FAILURE IN CUTANEOUS LEISHMANIASIS |
title_fullStr |
MONTENEGRO SKIN TEST AND AGE OF SKIN LESION AS PREDICTORS OF TREATMENT FAILURE IN CUTANEOUS LEISHMANIASIS |
title_full_unstemmed |
MONTENEGRO SKIN TEST AND AGE OF SKIN LESION AS PREDICTORS OF TREATMENT FAILURE IN CUTANEOUS LEISHMANIASIS |
title_sort |
montenegro skin test and age of skin lesion as predictors of treatment failure in cutaneous leishmaniasis |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2014 |
url |
https://doi.org/10.1590/S0036-46652014000500002 https://doaj.org/article/b086a46ca94c458088e463b47656754f |
long_lat |
ENVELOPE(-65.633,-65.633,-65.400,-65.400) |
geographic |
Arctic Evandro |
geographic_facet |
Arctic Evandro |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 56, Iss 5, Pp 375-380 (2014) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652014000500375&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/S0036-46652014000500002 https://doaj.org/article/b086a46ca94c458088e463b47656754f |
op_doi |
https://doi.org/10.1590/S0036-46652014000500002 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
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56 |
container_issue |
5 |
container_start_page |
375 |
op_container_end_page |
380 |
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