Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil
Abstract INTRODUCTION: Benznidazole is used for treating Chagas disease (CD). This cross-sectional study aimed to characterize the adverse drug reactions (ADRs) of benznidazole at a public hospital in Brazil’s Federal District. METHODS: Medical records were analyzed and ADRs were categorized by type...
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Online Access: | https://doi.org/10.1590/0037-8682-0150-2019 https://doaj.org/article/b008dce33aa3473d957c8c8f7a2ddbca |
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ftdoajarticles:oai:doaj.org/article:b008dce33aa3473d957c8c8f7a2ddbca 2023-05-15T15:01:16+02:00 Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil Maria Katarine Costa Lucas Gontijo Hilda Maria Benevides da Silva de Arruda Elza Ferreira Noronha Maria Inês de Toledo 2020-01-01T00:00:00Z https://doi.org/10.1590/0037-8682-0150-2019 https://doaj.org/article/b008dce33aa3473d957c8c8f7a2ddbca EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100622&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0150-2019 https://doaj.org/article/b008dce33aa3473d957c8c8f7a2ddbca Revista da Sociedade Brasileira de Medicina Tropical, Vol 53 (2020) Chagas disease Benznidazole Drug-related side effects Adverse reactions Arctic medicine. Tropical medicine RC955-962 article 2020 ftdoajarticles https://doi.org/10.1590/0037-8682-0150-2019 2022-12-30T21:38:58Z Abstract INTRODUCTION: Benznidazole is used for treating Chagas disease (CD). This cross-sectional study aimed to characterize the adverse drug reactions (ADRs) of benznidazole at a public hospital in Brazil’s Federal District. METHODS: Medical records were analyzed and ADRs were categorized by type, intensity, seriousness, and causality. RESULTS: Of the 62 patients who started benznidazole treatment for CD, 41 (66%) presented with 105 ADRs; 23 (37%) discontinued the treatment. Most reactions were classified as probable (81%), severe (63%), serious (67%), and dose-dependent (56%). CONCLUSIONS: The high incidence of ADRs because of treatment withdrawal revealed the need for safer alternatives for CD treatment. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 53 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Chagas disease Benznidazole Drug-related side effects Adverse reactions Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Chagas disease Benznidazole Drug-related side effects Adverse reactions Arctic medicine. Tropical medicine RC955-962 Maria Katarine Costa Lucas Gontijo Hilda Maria Benevides da Silva de Arruda Elza Ferreira Noronha Maria Inês de Toledo Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil |
topic_facet |
Chagas disease Benznidazole Drug-related side effects Adverse reactions Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract INTRODUCTION: Benznidazole is used for treating Chagas disease (CD). This cross-sectional study aimed to characterize the adverse drug reactions (ADRs) of benznidazole at a public hospital in Brazil’s Federal District. METHODS: Medical records were analyzed and ADRs were categorized by type, intensity, seriousness, and causality. RESULTS: Of the 62 patients who started benznidazole treatment for CD, 41 (66%) presented with 105 ADRs; 23 (37%) discontinued the treatment. Most reactions were classified as probable (81%), severe (63%), serious (67%), and dose-dependent (56%). CONCLUSIONS: The high incidence of ADRs because of treatment withdrawal revealed the need for safer alternatives for CD treatment. |
format |
Article in Journal/Newspaper |
author |
Maria Katarine Costa Lucas Gontijo Hilda Maria Benevides da Silva de Arruda Elza Ferreira Noronha Maria Inês de Toledo |
author_facet |
Maria Katarine Costa Lucas Gontijo Hilda Maria Benevides da Silva de Arruda Elza Ferreira Noronha Maria Inês de Toledo |
author_sort |
Maria Katarine Costa Lucas Gontijo |
title |
Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil |
title_short |
Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil |
title_full |
Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil |
title_fullStr |
Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil |
title_full_unstemmed |
Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil |
title_sort |
characterization of adverse reactions to benznidazole in patients with chagas disease in the federal district, brazil |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2020 |
url |
https://doi.org/10.1590/0037-8682-0150-2019 https://doaj.org/article/b008dce33aa3473d957c8c8f7a2ddbca |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 53 (2020) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100622&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0150-2019 https://doaj.org/article/b008dce33aa3473d957c8c8f7a2ddbca |
op_doi |
https://doi.org/10.1590/0037-8682-0150-2019 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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53 |
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