The frequency of HLA alleles in a population of Inuit women of northern Quebec
Background. Human leukocyte antigen (HLA) alleles code for proteins that are involved in the recognition of foreign antigens and activation of the immune system. The frequency of HLA alleles varies across different populations. Objective. To describe the frequency of HLA alleles in a population of I...
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2013
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Online Access: | https://doi.org/10.3402/ijch.v72i0.21350 https://doaj.org/article/b0046db2cb574346b590e7c439d73016 |
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ftdoajarticles:oai:doaj.org/article:b0046db2cb574346b590e7c439d73016 2023-05-15T15:05:23+02:00 The frequency of HLA alleles in a population of Inuit women of northern Quebec Stephanie Metcalfe Michel Roger Marie-Claude Faucher François Coutlée Eduardo L. Franco Paul Brassard 2013-08-01T00:00:00Z https://doi.org/10.3402/ijch.v72i0.21350 https://doaj.org/article/b0046db2cb574346b590e7c439d73016 EN eng Taylor & Francis Group http://www.circumpolarhealthjournal.net/index.php/ijch/article/download/21350/pdf_1 https://doaj.org/toc/2242-3982 doi:10.3402/ijch.v72i0.21350 2242-3982 https://doaj.org/article/b0046db2cb574346b590e7c439d73016 International Journal of Circumpolar Health, Vol 72, Iss 0, Pp 1-4 (2013) human leukocyte antigen Inuit Nunavik Canada Arctic medicine. Tropical medicine RC955-962 article 2013 ftdoajarticles https://doi.org/10.3402/ijch.v72i0.21350 2022-12-31T08:38:25Z Background. Human leukocyte antigen (HLA) alleles code for proteins that are involved in the recognition of foreign antigens and activation of the immune system. The frequency of HLA alleles varies across different populations. Objective. To describe the frequency of HLA alleles in a population of Inuit women of Nunavik, Quebec, Canada. Design. A cohort of women was recruited from 4 different communities between January 2002 and December 2007. HLA-B*07, HLA-DQB1*03, DQB1*06:02, DRB1*13 and DRB1*15:01 alleles were typed by PCR sequence-specific primers (PCR-SSP) and HLA-E and G alleles were type by DNA-sequencing procedures. Results. We obtained data on 524 participants. The most frequent HLA alleles in this population were HLA-E*01:03, HLA-G*01:04:01 and HLA-DQB1*03, and they were found in 89, 75 and 94% of the population, respectively. Conclusions. The distribution of HLA alleles in Nunavik, Quebec is unique when compared to other populations in Canada or around the world. Article in Journal/Newspaper Arctic Circumpolar Health International Journal of Circumpolar Health inuit Nunavik Directory of Open Access Journals: DOAJ Articles Arctic Canada Nunavik International Journal of Circumpolar Health 72 1 21350 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
human leukocyte antigen Inuit Nunavik Canada Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
human leukocyte antigen Inuit Nunavik Canada Arctic medicine. Tropical medicine RC955-962 Stephanie Metcalfe Michel Roger Marie-Claude Faucher François Coutlée Eduardo L. Franco Paul Brassard The frequency of HLA alleles in a population of Inuit women of northern Quebec |
topic_facet |
human leukocyte antigen Inuit Nunavik Canada Arctic medicine. Tropical medicine RC955-962 |
description |
Background. Human leukocyte antigen (HLA) alleles code for proteins that are involved in the recognition of foreign antigens and activation of the immune system. The frequency of HLA alleles varies across different populations. Objective. To describe the frequency of HLA alleles in a population of Inuit women of Nunavik, Quebec, Canada. Design. A cohort of women was recruited from 4 different communities between January 2002 and December 2007. HLA-B*07, HLA-DQB1*03, DQB1*06:02, DRB1*13 and DRB1*15:01 alleles were typed by PCR sequence-specific primers (PCR-SSP) and HLA-E and G alleles were type by DNA-sequencing procedures. Results. We obtained data on 524 participants. The most frequent HLA alleles in this population were HLA-E*01:03, HLA-G*01:04:01 and HLA-DQB1*03, and they were found in 89, 75 and 94% of the population, respectively. Conclusions. The distribution of HLA alleles in Nunavik, Quebec is unique when compared to other populations in Canada or around the world. |
format |
Article in Journal/Newspaper |
author |
Stephanie Metcalfe Michel Roger Marie-Claude Faucher François Coutlée Eduardo L. Franco Paul Brassard |
author_facet |
Stephanie Metcalfe Michel Roger Marie-Claude Faucher François Coutlée Eduardo L. Franco Paul Brassard |
author_sort |
Stephanie Metcalfe |
title |
The frequency of HLA alleles in a population of Inuit women of northern Quebec |
title_short |
The frequency of HLA alleles in a population of Inuit women of northern Quebec |
title_full |
The frequency of HLA alleles in a population of Inuit women of northern Quebec |
title_fullStr |
The frequency of HLA alleles in a population of Inuit women of northern Quebec |
title_full_unstemmed |
The frequency of HLA alleles in a population of Inuit women of northern Quebec |
title_sort |
frequency of hla alleles in a population of inuit women of northern quebec |
publisher |
Taylor & Francis Group |
publishDate |
2013 |
url |
https://doi.org/10.3402/ijch.v72i0.21350 https://doaj.org/article/b0046db2cb574346b590e7c439d73016 |
geographic |
Arctic Canada Nunavik |
geographic_facet |
Arctic Canada Nunavik |
genre |
Arctic Circumpolar Health International Journal of Circumpolar Health inuit Nunavik |
genre_facet |
Arctic Circumpolar Health International Journal of Circumpolar Health inuit Nunavik |
op_source |
International Journal of Circumpolar Health, Vol 72, Iss 0, Pp 1-4 (2013) |
op_relation |
http://www.circumpolarhealthjournal.net/index.php/ijch/article/download/21350/pdf_1 https://doaj.org/toc/2242-3982 doi:10.3402/ijch.v72i0.21350 2242-3982 https://doaj.org/article/b0046db2cb574346b590e7c439d73016 |
op_doi |
https://doi.org/10.3402/ijch.v72i0.21350 |
container_title |
International Journal of Circumpolar Health |
container_volume |
72 |
container_issue |
1 |
container_start_page |
21350 |
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1766337089524203520 |