A bioreactor system for the manufacture of a genetically modified Plasmodium falciparum blood stage malaria cell bank for use in a clinical trial

Abstract Background Although the use of induced blood stage malaria infection has proven to be a valuable tool for testing the efficacy of vaccines and drugs against Plasmodium falciparum, a limiting factor has been the availability of Good Manufacturing Practice (GMP)—compliant defined P. falciparu...

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Bibliographic Details
Published in:Malaria Journal
Main Authors: Rebecca Pawliw, Rebecca Farrow, Silvana Sekuloski, Helen Jennings, Julie Healer, Thuan Phuong, Pri Sathe, Cielo Pasay, Krystal Evans, Alan F. Cowman, Louis Schofield, Nanhua Chen, James McCarthy, Katharine Trenholme
Format: Article in Journal/Newspaper
Language:English
Published: BMC 2018
Subjects:
Malaria
Plasmodium falciparum
Bioreactor
In vitro cultivation
Good Manufacturing Practice
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
Arctic
The Knob
Online Access:https://doi.org/10.1186/s12936-018-2435-x
https://doaj.org/article/afed1c50820b48f497a9eb2b6f34ff09

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