Phialemonium curvatum infection after bone marrow transplantation Infecção por Phialemonium curvatum pós-transplante de medula óssea
We report a case of cutaneous infection caused by Phialemonium curvatum GAMS et COOKE, 1983, after bone marrow transplantation. The genus Phialemonium was created by GAMS & MCGINNIS in 1983 including three new species: Ph. obovatum, Ph. curvatum and Ph. dimorphosporum, and represents an intermed...
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Universidade de São Paulo (USP)
2001
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ftdoajarticles:oai:doaj.org/article:af9ce57145ea437eb0e0592d2a4029c7 2024-09-09T19:26:46+00:00 Phialemonium curvatum infection after bone marrow transplantation Infecção por Phialemonium curvatum pós-transplante de medula óssea Elisabeth Maria HEINS-VACCARI Clarisse M. MACHADO Rosaura S. SABOYA Roberto L. SILVA Frederico L. DULLEY Carlos da S. LACAZ Roseli S. de FREITAS LEITE Giovana L. HERNANDEZ ARRIAGADA 2001-06-01T00:00:00Z https://doi.org/10.1590/S0036-46652001000300009 https://doaj.org/article/af9ce57145ea437eb0e0592d2a4029c7 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652001000300009 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46652001000300009 0036-4665 1678-9946 https://doaj.org/article/af9ce57145ea437eb0e0592d2a4029c7 Revista do Instituto de Medicina Tropical de São Paulo, Vol 43, Iss 3, Pp 163-166 (2001) Phialemonium curvatum Bone marrow transplantation Phaeohyphomycosis Hyalohyphomycosis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2001 ftdoajarticles https://doi.org/10.1590/S0036-46652001000300009 2024-08-05T17:49:30Z We report a case of cutaneous infection caused by Phialemonium curvatum GAMS et COOKE, 1983, after bone marrow transplantation. The genus Phialemonium was created by GAMS & MCGINNIS in 1983 including three new species: Ph. obovatum, Ph. curvatum and Ph. dimorphosporum, and represents an intermediate genus between Acremonium and Phialophora. Nowadays, the genus Phialemonium is considered to be a pheoid fungus which may cause the eventual lesions observed in pheo- and hyalohyphomycosis. Species of this genus have been described as opportunistic agents in humans and animals, mainly as a result of immunosuppression. In the present case, the patient had multiple myeloma and received an allogenic bone marrow transplant from his HLA-compatible brother. Two months after transplantation, he developed purplish and painful nodular lesions on the right ankle. Some of these lesions drained spontaneously and apparently hyaline mycelial filaments were observed, whose culture was initially identified as Acremonium sp. Subsequent studies showed that the fungus was Phialemonium curvatum. The infection was treated with amphotericin B, followed by ketoconazole. The patient was submitted to surgical debridement followed by two skin grafts to repair the bloody area. The duration of the treatment was 4 months and secondary prophylaxis with ketoconazole alone was maintained for one additional month. No recurrence was observed after discontinuation of treatment. The authors comment on the pathogenicity of the genus Phialemonium. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 43 3 163 166 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Phialemonium curvatum Bone marrow transplantation Phaeohyphomycosis Hyalohyphomycosis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Phialemonium curvatum Bone marrow transplantation Phaeohyphomycosis Hyalohyphomycosis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Elisabeth Maria HEINS-VACCARI Clarisse M. MACHADO Rosaura S. SABOYA Roberto L. SILVA Frederico L. DULLEY Carlos da S. LACAZ Roseli S. de FREITAS LEITE Giovana L. HERNANDEZ ARRIAGADA Phialemonium curvatum infection after bone marrow transplantation Infecção por Phialemonium curvatum pós-transplante de medula óssea |
topic_facet |
Phialemonium curvatum Bone marrow transplantation Phaeohyphomycosis Hyalohyphomycosis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
We report a case of cutaneous infection caused by Phialemonium curvatum GAMS et COOKE, 1983, after bone marrow transplantation. The genus Phialemonium was created by GAMS & MCGINNIS in 1983 including three new species: Ph. obovatum, Ph. curvatum and Ph. dimorphosporum, and represents an intermediate genus between Acremonium and Phialophora. Nowadays, the genus Phialemonium is considered to be a pheoid fungus which may cause the eventual lesions observed in pheo- and hyalohyphomycosis. Species of this genus have been described as opportunistic agents in humans and animals, mainly as a result of immunosuppression. In the present case, the patient had multiple myeloma and received an allogenic bone marrow transplant from his HLA-compatible brother. Two months after transplantation, he developed purplish and painful nodular lesions on the right ankle. Some of these lesions drained spontaneously and apparently hyaline mycelial filaments were observed, whose culture was initially identified as Acremonium sp. Subsequent studies showed that the fungus was Phialemonium curvatum. The infection was treated with amphotericin B, followed by ketoconazole. The patient was submitted to surgical debridement followed by two skin grafts to repair the bloody area. The duration of the treatment was 4 months and secondary prophylaxis with ketoconazole alone was maintained for one additional month. No recurrence was observed after discontinuation of treatment. The authors comment on the pathogenicity of the genus Phialemonium. |
format |
Article in Journal/Newspaper |
author |
Elisabeth Maria HEINS-VACCARI Clarisse M. MACHADO Rosaura S. SABOYA Roberto L. SILVA Frederico L. DULLEY Carlos da S. LACAZ Roseli S. de FREITAS LEITE Giovana L. HERNANDEZ ARRIAGADA |
author_facet |
Elisabeth Maria HEINS-VACCARI Clarisse M. MACHADO Rosaura S. SABOYA Roberto L. SILVA Frederico L. DULLEY Carlos da S. LACAZ Roseli S. de FREITAS LEITE Giovana L. HERNANDEZ ARRIAGADA |
author_sort |
Elisabeth Maria HEINS-VACCARI |
title |
Phialemonium curvatum infection after bone marrow transplantation Infecção por Phialemonium curvatum pós-transplante de medula óssea |
title_short |
Phialemonium curvatum infection after bone marrow transplantation Infecção por Phialemonium curvatum pós-transplante de medula óssea |
title_full |
Phialemonium curvatum infection after bone marrow transplantation Infecção por Phialemonium curvatum pós-transplante de medula óssea |
title_fullStr |
Phialemonium curvatum infection after bone marrow transplantation Infecção por Phialemonium curvatum pós-transplante de medula óssea |
title_full_unstemmed |
Phialemonium curvatum infection after bone marrow transplantation Infecção por Phialemonium curvatum pós-transplante de medula óssea |
title_sort |
phialemonium curvatum infection after bone marrow transplantation infecção por phialemonium curvatum pós-transplante de medula óssea |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2001 |
url |
https://doi.org/10.1590/S0036-46652001000300009 https://doaj.org/article/af9ce57145ea437eb0e0592d2a4029c7 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 43, Iss 3, Pp 163-166 (2001) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652001000300009 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46652001000300009 0036-4665 1678-9946 https://doaj.org/article/af9ce57145ea437eb0e0592d2a4029c7 |
op_doi |
https://doi.org/10.1590/S0036-46652001000300009 |
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Revista do Instituto de Medicina Tropical de São Paulo |
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43 |
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3 |
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163 |
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