Family occurrence of schistosomal hepatosplenomegaly and maternal effect
In this paper we present a study of members of 265 nuclear families, aged six or more. This study is based of family heredograms, and takes into account the clinical form ofschistosomiasis observed before treatment with oxamniquine. The probability of occurrence of two or more cases ofhepatosplenome...
Published in: | Revista da Sociedade Brasileira de Medicina Tropical |
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Sociedade Brasileira de Medicina Tropical (SBMT)
1989
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Online Access: | https://doi.org/10.1590/S0037-86821989000100003 https://doaj.org/article/af8eaba679ae401da6dfa940d96beeac |
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ftdoajarticles:oai:doaj.org/article:af8eaba679ae401da6dfa940d96beeac 2023-05-15T15:08:51+02:00 Family occurrence of schistosomal hepatosplenomegaly and maternal effect José Tavares-Neto Aluizio Prata 1989-03-01T00:00:00Z https://doi.org/10.1590/S0037-86821989000100003 https://doaj.org/article/af8eaba679ae401da6dfa940d96beeac EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821989000100003&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/S0037-86821989000100003 https://doaj.org/article/af8eaba679ae401da6dfa940d96beeac Revista da Sociedade Brasileira de Medicina Tropical, Vol 22, Iss 1, Pp 13-18 (1989) Esquistossomose Recorrência familial Efeito materno Arctic medicine. Tropical medicine RC955-962 article 1989 ftdoajarticles https://doi.org/10.1590/S0037-86821989000100003 2022-12-30T23:17:51Z In this paper we present a study of members of 265 nuclear families, aged six or more. This study is based of family heredograms, and takes into account the clinical form ofschistosomiasis observed before treatment with oxamniquine. The probability of occurrence of two or more cases ofhepatosplenomegaly is low, notwithstanding the fact that it was observed in 38 families. Even less frequent is the occurrence of three or more cases observed in 17 families (P=0.002). The concentration of the hepatosplenic form was higher among siblings than it was among mothers and children, or fathers and children. It was found to be not significant between husband (father) and wife (mother). These observations reinforce the evidence for the presence of a genetic component in susceptibility to the hepatosplenic form of the disease. In cases in which the mother was hepatosplenic there was a higher incidence of hepatosplenic children; the relative risk was a least five times higher than in those in which the father was the affected member (the maternal effect). In cases where both members were affected by the hepatointestinal form, the risk to the filial generation was similar to that of the population in general. Thus, in the process towards severe forms of Schistosomiasis mansoni, pre and post natal factors might be involved. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 22 1 13 18 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Esquistossomose Recorrência familial Efeito materno Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Esquistossomose Recorrência familial Efeito materno Arctic medicine. Tropical medicine RC955-962 José Tavares-Neto Aluizio Prata Family occurrence of schistosomal hepatosplenomegaly and maternal effect |
topic_facet |
Esquistossomose Recorrência familial Efeito materno Arctic medicine. Tropical medicine RC955-962 |
description |
In this paper we present a study of members of 265 nuclear families, aged six or more. This study is based of family heredograms, and takes into account the clinical form ofschistosomiasis observed before treatment with oxamniquine. The probability of occurrence of two or more cases ofhepatosplenomegaly is low, notwithstanding the fact that it was observed in 38 families. Even less frequent is the occurrence of three or more cases observed in 17 families (P=0.002). The concentration of the hepatosplenic form was higher among siblings than it was among mothers and children, or fathers and children. It was found to be not significant between husband (father) and wife (mother). These observations reinforce the evidence for the presence of a genetic component in susceptibility to the hepatosplenic form of the disease. In cases in which the mother was hepatosplenic there was a higher incidence of hepatosplenic children; the relative risk was a least five times higher than in those in which the father was the affected member (the maternal effect). In cases where both members were affected by the hepatointestinal form, the risk to the filial generation was similar to that of the population in general. Thus, in the process towards severe forms of Schistosomiasis mansoni, pre and post natal factors might be involved. |
format |
Article in Journal/Newspaper |
author |
José Tavares-Neto Aluizio Prata |
author_facet |
José Tavares-Neto Aluizio Prata |
author_sort |
José Tavares-Neto |
title |
Family occurrence of schistosomal hepatosplenomegaly and maternal effect |
title_short |
Family occurrence of schistosomal hepatosplenomegaly and maternal effect |
title_full |
Family occurrence of schistosomal hepatosplenomegaly and maternal effect |
title_fullStr |
Family occurrence of schistosomal hepatosplenomegaly and maternal effect |
title_full_unstemmed |
Family occurrence of schistosomal hepatosplenomegaly and maternal effect |
title_sort |
family occurrence of schistosomal hepatosplenomegaly and maternal effect |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
1989 |
url |
https://doi.org/10.1590/S0037-86821989000100003 https://doaj.org/article/af8eaba679ae401da6dfa940d96beeac |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 22, Iss 1, Pp 13-18 (1989) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821989000100003&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/S0037-86821989000100003 https://doaj.org/article/af8eaba679ae401da6dfa940d96beeac |
op_doi |
https://doi.org/10.1590/S0037-86821989000100003 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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22 |
container_issue |
1 |
container_start_page |
13 |
op_container_end_page |
18 |
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