Polymorphism of the adiponutrin gene (PNPLA3) in the indigenous inhabitants of the Republic of Sakha (Yakutia) with type 2 diabetes mellitus
Rationale: The association of rs738409 I148M polymorphism with type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease has been confirmed for several ethnic and territorial groups. Up to now, no such studies have been performed in the populations of Yakutia.Aim: To study allele frequen...
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ftdoajarticles:oai:doaj.org/article:af7b428718d3418181294bfbd9e9a8b6 2023-05-15T18:06:37+02:00 Polymorphism of the adiponutrin gene (PNPLA3) in the indigenous inhabitants of the Republic of Sakha (Yakutia) with type 2 diabetes mellitus Kh. A. Kurtanov L. A. Sydykova N. I. Pavlova N. P. Filippova V. V. Dodokhov G. A. Apsolikhova N. A. Solov'eva A. T. D'yakonova L. M. Neustroeva M. A. Varlamova N. V. Borisova 2018-08-01T00:00:00Z https://doi.org/10.18786/2072-0505-2018-46-3-258-263 https://doaj.org/article/af7b428718d3418181294bfbd9e9a8b6 RU rus MONIKI https://www.almclinmed.ru/jour/article/view/827 https://doaj.org/toc/2072-0505 https://doaj.org/toc/2587-9294 2072-0505 2587-9294 doi:10.18786/2072-0505-2018-46-3-258-263 https://doaj.org/article/af7b428718d3418181294bfbd9e9a8b6 Alʹmanah Kliničeskoj Mediciny, Vol 46, Iss 3, Pp 258-263 (2018) type 2 diabetes mellitus insulin resistance adiponutrin gene polymorphism Medicine R article 2018 ftdoajarticles https://doi.org/10.18786/2072-0505-2018-46-3-258-263 2022-12-31T06:19:56Z Rationale: The association of rs738409 I148M polymorphism with type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease has been confirmed for several ethnic and territorial groups. Up to now, no such studies have been performed in the populations of Yakutia.Aim: To study allele frequency distribution and to identify associations of the PNPLA3 gene polymorphism (rs738409 C>G) with T2DM in the Yakuts.Materials and methods: DNA samples from 106 T2DM patients were used in the study; the control group included samples from 72 healthy volunteers. All study participants were ethnic Yakuts and were living in the territory of the Republic of Sakha (Yakutia), Russian Federation. rs738409 polymorphism of the PNPLA3 gene was studied by polymerase chain reaction and by restriction fragment length polymorphism.Results: There were no significant difference in the distribution of the allele frequencies and genotypes of the polymorphous variant of the PNPLA3 gene (rs738409) between the T2DM patients and the healthy control. Both groups showed prevailing allele G (р = 0.01) and homozygous genotype GG (96%).Conclusion: High frequency of the allele G (74.1%) with predominance of GG genotype (58.5%) was found in type 2 diabetic patients. Article in Journal/Newspaper Republic of Sakha Yakutia Yakuts Directory of Open Access Journals: DOAJ Articles Sakha Almanac of Clinical Medicine 46 3 258 263 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
Russian |
topic |
type 2 diabetes mellitus insulin resistance adiponutrin gene polymorphism Medicine R |
spellingShingle |
type 2 diabetes mellitus insulin resistance adiponutrin gene polymorphism Medicine R Kh. A. Kurtanov L. A. Sydykova N. I. Pavlova N. P. Filippova V. V. Dodokhov G. A. Apsolikhova N. A. Solov'eva A. T. D'yakonova L. M. Neustroeva M. A. Varlamova N. V. Borisova Polymorphism of the adiponutrin gene (PNPLA3) in the indigenous inhabitants of the Republic of Sakha (Yakutia) with type 2 diabetes mellitus |
topic_facet |
type 2 diabetes mellitus insulin resistance adiponutrin gene polymorphism Medicine R |
description |
Rationale: The association of rs738409 I148M polymorphism with type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease has been confirmed for several ethnic and territorial groups. Up to now, no such studies have been performed in the populations of Yakutia.Aim: To study allele frequency distribution and to identify associations of the PNPLA3 gene polymorphism (rs738409 C>G) with T2DM in the Yakuts.Materials and methods: DNA samples from 106 T2DM patients were used in the study; the control group included samples from 72 healthy volunteers. All study participants were ethnic Yakuts and were living in the territory of the Republic of Sakha (Yakutia), Russian Federation. rs738409 polymorphism of the PNPLA3 gene was studied by polymerase chain reaction and by restriction fragment length polymorphism.Results: There were no significant difference in the distribution of the allele frequencies and genotypes of the polymorphous variant of the PNPLA3 gene (rs738409) between the T2DM patients and the healthy control. Both groups showed prevailing allele G (р = 0.01) and homozygous genotype GG (96%).Conclusion: High frequency of the allele G (74.1%) with predominance of GG genotype (58.5%) was found in type 2 diabetic patients. |
format |
Article in Journal/Newspaper |
author |
Kh. A. Kurtanov L. A. Sydykova N. I. Pavlova N. P. Filippova V. V. Dodokhov G. A. Apsolikhova N. A. Solov'eva A. T. D'yakonova L. M. Neustroeva M. A. Varlamova N. V. Borisova |
author_facet |
Kh. A. Kurtanov L. A. Sydykova N. I. Pavlova N. P. Filippova V. V. Dodokhov G. A. Apsolikhova N. A. Solov'eva A. T. D'yakonova L. M. Neustroeva M. A. Varlamova N. V. Borisova |
author_sort |
Kh. A. Kurtanov |
title |
Polymorphism of the adiponutrin gene (PNPLA3) in the indigenous inhabitants of the Republic of Sakha (Yakutia) with type 2 diabetes mellitus |
title_short |
Polymorphism of the adiponutrin gene (PNPLA3) in the indigenous inhabitants of the Republic of Sakha (Yakutia) with type 2 diabetes mellitus |
title_full |
Polymorphism of the adiponutrin gene (PNPLA3) in the indigenous inhabitants of the Republic of Sakha (Yakutia) with type 2 diabetes mellitus |
title_fullStr |
Polymorphism of the adiponutrin gene (PNPLA3) in the indigenous inhabitants of the Republic of Sakha (Yakutia) with type 2 diabetes mellitus |
title_full_unstemmed |
Polymorphism of the adiponutrin gene (PNPLA3) in the indigenous inhabitants of the Republic of Sakha (Yakutia) with type 2 diabetes mellitus |
title_sort |
polymorphism of the adiponutrin gene (pnpla3) in the indigenous inhabitants of the republic of sakha (yakutia) with type 2 diabetes mellitus |
publisher |
MONIKI |
publishDate |
2018 |
url |
https://doi.org/10.18786/2072-0505-2018-46-3-258-263 https://doaj.org/article/af7b428718d3418181294bfbd9e9a8b6 |
geographic |
Sakha |
geographic_facet |
Sakha |
genre |
Republic of Sakha Yakutia Yakuts |
genre_facet |
Republic of Sakha Yakutia Yakuts |
op_source |
Alʹmanah Kliničeskoj Mediciny, Vol 46, Iss 3, Pp 258-263 (2018) |
op_relation |
https://www.almclinmed.ru/jour/article/view/827 https://doaj.org/toc/2072-0505 https://doaj.org/toc/2587-9294 2072-0505 2587-9294 doi:10.18786/2072-0505-2018-46-3-258-263 https://doaj.org/article/af7b428718d3418181294bfbd9e9a8b6 |
op_doi |
https://doi.org/10.18786/2072-0505-2018-46-3-258-263 |
container_title |
Almanac of Clinical Medicine |
container_volume |
46 |
container_issue |
3 |
container_start_page |
258 |
op_container_end_page |
263 |
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1766178262913908736 |