Prevalence of Plasmodium falciparum infection among pregnant women at first antenatal visit in post-Ebola Monrovia, Liberia
Abstract Background Disruption of malaria control strategies during the West African 2014–2016 Ebola epidemic led to an increase in malaria-attributable mortality. However, recent data on malaria infection in vulnerable groups, such as pregnant women, are lacking in this post-Ebola scenario. This cr...
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ftdoajarticles:oai:doaj.org/article:af25a19c7148429e94291df0311f3fa1 2023-05-15T15:15:14+02:00 Prevalence of Plasmodium falciparum infection among pregnant women at first antenatal visit in post-Ebola Monrovia, Liberia Guillermo Martínez-Pérez Dawoh Peter Lansana Senga Omeonga Himanshu Gupta Bondey Breeze-Barry Raquel González Azucena Bardají Adelaida Sarukhan James D. K. Goteh Edith Tody Pau Cisteró Benard Benda Juwe D. Kercula Fanta D. Kibungu Ana Meyer García-Sípido Quique Bassat Christine K. Tarr-Attia Alfredo Mayor 2018-10-01T00:00:00Z https://doi.org/10.1186/s12936-018-2506-z https://doaj.org/article/af25a19c7148429e94291df0311f3fa1 EN eng BMC http://link.springer.com/article/10.1186/s12936-018-2506-z https://doaj.org/toc/1475-2875 doi:10.1186/s12936-018-2506-z 1475-2875 https://doaj.org/article/af25a19c7148429e94291df0311f3fa1 Malaria Journal, Vol 17, Iss 1, Pp 1-10 (2018) Malaria Pregnancy Prevalence Antenatal Liberia Parasite resistance Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2018 ftdoajarticles https://doi.org/10.1186/s12936-018-2506-z 2022-12-31T13:04:51Z Abstract Background Disruption of malaria control strategies during the West African 2014–2016 Ebola epidemic led to an increase in malaria-attributable mortality. However, recent data on malaria infection in vulnerable groups, such as pregnant women, are lacking in this post-Ebola scenario. This cross-sectional study aimed to assess the prevalence of Plasmodium falciparum infection and of molecular markers of drug resistance among pregnant women attending antenatal care in Monrovia, capital of Liberia. Methods From October 2016 to June 2017, all pregnant women attending their first antenatal care visit at the Saint Joseph’s Catholic Hospital, Monrovia, were invited to participate in the study. In addition to their routine antenatal care tests, capillary blood spotted onto filter papers were collected from all consenting participants to determine presence of P. falciparum by real-time quantitative PCR. Molecular markers of anti-malarial drug resistance were assessed through Sanger sequencing and quantitative PCR in specimens positive for P. falciparum analysis. Results Of the 195 women participants, 24 (12.3%) were P. falciparum-positive by qPCR. Infected women tended to be more commonly primigravidae and younger than uninfected ones. Parasite densities were higher in primigravidae. Fever was more frequently detected among the infected women. No statistically significant association between P. falciparum infection and haemoglobin levels or insecticide-treated net use was found. While high prevalence of genetic polymorphisms associated with chloroquine and amodiaquine resistance were detected, no molecular markers of artemisinin resistance were observed. Conclusion Plasmodium falciparum infections are expected to occur in at least one in every eight women attending first ANC at private clinics in Monrovia and outside the peak of the rainy season. Young primigravidae are at increased risk of P. falciparum infection. Molecular analyses did not provide evidence of resistance to artemisinins among the P. falciparum ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 17 1 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Malaria Pregnancy Prevalence Antenatal Liberia Parasite resistance Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Malaria Pregnancy Prevalence Antenatal Liberia Parasite resistance Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Guillermo Martínez-Pérez Dawoh Peter Lansana Senga Omeonga Himanshu Gupta Bondey Breeze-Barry Raquel González Azucena Bardají Adelaida Sarukhan James D. K. Goteh Edith Tody Pau Cisteró Benard Benda Juwe D. Kercula Fanta D. Kibungu Ana Meyer García-Sípido Quique Bassat Christine K. Tarr-Attia Alfredo Mayor Prevalence of Plasmodium falciparum infection among pregnant women at first antenatal visit in post-Ebola Monrovia, Liberia |
topic_facet |
Malaria Pregnancy Prevalence Antenatal Liberia Parasite resistance Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Disruption of malaria control strategies during the West African 2014–2016 Ebola epidemic led to an increase in malaria-attributable mortality. However, recent data on malaria infection in vulnerable groups, such as pregnant women, are lacking in this post-Ebola scenario. This cross-sectional study aimed to assess the prevalence of Plasmodium falciparum infection and of molecular markers of drug resistance among pregnant women attending antenatal care in Monrovia, capital of Liberia. Methods From October 2016 to June 2017, all pregnant women attending their first antenatal care visit at the Saint Joseph’s Catholic Hospital, Monrovia, were invited to participate in the study. In addition to their routine antenatal care tests, capillary blood spotted onto filter papers were collected from all consenting participants to determine presence of P. falciparum by real-time quantitative PCR. Molecular markers of anti-malarial drug resistance were assessed through Sanger sequencing and quantitative PCR in specimens positive for P. falciparum analysis. Results Of the 195 women participants, 24 (12.3%) were P. falciparum-positive by qPCR. Infected women tended to be more commonly primigravidae and younger than uninfected ones. Parasite densities were higher in primigravidae. Fever was more frequently detected among the infected women. No statistically significant association between P. falciparum infection and haemoglobin levels or insecticide-treated net use was found. While high prevalence of genetic polymorphisms associated with chloroquine and amodiaquine resistance were detected, no molecular markers of artemisinin resistance were observed. Conclusion Plasmodium falciparum infections are expected to occur in at least one in every eight women attending first ANC at private clinics in Monrovia and outside the peak of the rainy season. Young primigravidae are at increased risk of P. falciparum infection. Molecular analyses did not provide evidence of resistance to artemisinins among the P. falciparum ... |
format |
Article in Journal/Newspaper |
author |
Guillermo Martínez-Pérez Dawoh Peter Lansana Senga Omeonga Himanshu Gupta Bondey Breeze-Barry Raquel González Azucena Bardají Adelaida Sarukhan James D. K. Goteh Edith Tody Pau Cisteró Benard Benda Juwe D. Kercula Fanta D. Kibungu Ana Meyer García-Sípido Quique Bassat Christine K. Tarr-Attia Alfredo Mayor |
author_facet |
Guillermo Martínez-Pérez Dawoh Peter Lansana Senga Omeonga Himanshu Gupta Bondey Breeze-Barry Raquel González Azucena Bardají Adelaida Sarukhan James D. K. Goteh Edith Tody Pau Cisteró Benard Benda Juwe D. Kercula Fanta D. Kibungu Ana Meyer García-Sípido Quique Bassat Christine K. Tarr-Attia Alfredo Mayor |
author_sort |
Guillermo Martínez-Pérez |
title |
Prevalence of Plasmodium falciparum infection among pregnant women at first antenatal visit in post-Ebola Monrovia, Liberia |
title_short |
Prevalence of Plasmodium falciparum infection among pregnant women at first antenatal visit in post-Ebola Monrovia, Liberia |
title_full |
Prevalence of Plasmodium falciparum infection among pregnant women at first antenatal visit in post-Ebola Monrovia, Liberia |
title_fullStr |
Prevalence of Plasmodium falciparum infection among pregnant women at first antenatal visit in post-Ebola Monrovia, Liberia |
title_full_unstemmed |
Prevalence of Plasmodium falciparum infection among pregnant women at first antenatal visit in post-Ebola Monrovia, Liberia |
title_sort |
prevalence of plasmodium falciparum infection among pregnant women at first antenatal visit in post-ebola monrovia, liberia |
publisher |
BMC |
publishDate |
2018 |
url |
https://doi.org/10.1186/s12936-018-2506-z https://doaj.org/article/af25a19c7148429e94291df0311f3fa1 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 17, Iss 1, Pp 1-10 (2018) |
op_relation |
http://link.springer.com/article/10.1186/s12936-018-2506-z https://doaj.org/toc/1475-2875 doi:10.1186/s12936-018-2506-z 1475-2875 https://doaj.org/article/af25a19c7148429e94291df0311f3fa1 |
op_doi |
https://doi.org/10.1186/s12936-018-2506-z |
container_title |
Malaria Journal |
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17 |
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1 |
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1766345602514288640 |