Biochemical and hematological study of goats envenomed with natural and 60Co-irradiated bothropic venom
Venoms from snakes of the Bothrops genus are proteolytic, coagulant, hemorrhagic and nephrotoxic, causing edema, necrosis, hemorrhage and intense pain at the bite site, besides systemic alterations. Many adjuvants have been added to the venom used in the sensitization of antiserum-producer animals t...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:af1c559467344331ad4ab9f52371cebe 2023-05-15T15:07:40+02:00 Biochemical and hematological study of goats envenomed with natural and 60Co-irradiated bothropic venom P. C. Lucas de Oliveira M. Sakate R. A. Madruga N. P.U. Barbosa 2007-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992007000300003 https://doaj.org/article/af1c559467344331ad4ab9f52371cebe EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000300003 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992007000300003 1678-9199 https://doaj.org/article/af1c559467344331ad4ab9f52371cebe Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 13, Iss 3, Pp 576-597 (2007) radiation Bothrops jararaca cobalt goats Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2007 ftdoajarticles https://doi.org/10.1590/S1678-91992007000300003 2022-12-31T01:19:04Z Venoms from snakes of the Bothrops genus are proteolytic, coagulant, hemorrhagic and nephrotoxic, causing edema, necrosis, hemorrhage and intense pain at the bite site, besides systemic alterations. Many adjuvants have been added to the venom used in the sensitization of antiserum-producer animals to increase antigenic induction and reduce the envenomation pathological effects. Gamma radiation from 60Co has been used as an attenuating agent of the venoms toxic properties. The main objective was to study, comparatively, clinical and laboratory aspects of goats inoculated with bothropic (Bothrops jararaca) venom, natural and irradiated from a 60Co source. Twelve goats were divided into two groups of six animals: GINV, inoculated with 0.5mg/kg of natural venom; and GIIV, inoculated with 0.5mg/kg of irradiated venom. Blood samples were collected immediately before and one, two, seven, and thirty days after venom injection. Local lesions were daily evaluated. The following exams were carried out: blood tests; biochemical tests of urea, creatinine, creatine kinase (CK), aspartate amino-transferase (AST) and alanine amino-transferase (ALT); clotting time; platelets count; and total serum immunoglobulin measurement. In the conditions of the present experiment, irradiated venom was less aggressive and more immunogenic than natural venom. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 13 3 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
radiation Bothrops jararaca cobalt goats Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
radiation Bothrops jararaca cobalt goats Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 P. C. Lucas de Oliveira M. Sakate R. A. Madruga N. P.U. Barbosa Biochemical and hematological study of goats envenomed with natural and 60Co-irradiated bothropic venom |
topic_facet |
radiation Bothrops jararaca cobalt goats Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Venoms from snakes of the Bothrops genus are proteolytic, coagulant, hemorrhagic and nephrotoxic, causing edema, necrosis, hemorrhage and intense pain at the bite site, besides systemic alterations. Many adjuvants have been added to the venom used in the sensitization of antiserum-producer animals to increase antigenic induction and reduce the envenomation pathological effects. Gamma radiation from 60Co has been used as an attenuating agent of the venoms toxic properties. The main objective was to study, comparatively, clinical and laboratory aspects of goats inoculated with bothropic (Bothrops jararaca) venom, natural and irradiated from a 60Co source. Twelve goats were divided into two groups of six animals: GINV, inoculated with 0.5mg/kg of natural venom; and GIIV, inoculated with 0.5mg/kg of irradiated venom. Blood samples were collected immediately before and one, two, seven, and thirty days after venom injection. Local lesions were daily evaluated. The following exams were carried out: blood tests; biochemical tests of urea, creatinine, creatine kinase (CK), aspartate amino-transferase (AST) and alanine amino-transferase (ALT); clotting time; platelets count; and total serum immunoglobulin measurement. In the conditions of the present experiment, irradiated venom was less aggressive and more immunogenic than natural venom. |
format |
Article in Journal/Newspaper |
author |
P. C. Lucas de Oliveira M. Sakate R. A. Madruga N. P.U. Barbosa |
author_facet |
P. C. Lucas de Oliveira M. Sakate R. A. Madruga N. P.U. Barbosa |
author_sort |
P. C. Lucas de Oliveira |
title |
Biochemical and hematological study of goats envenomed with natural and 60Co-irradiated bothropic venom |
title_short |
Biochemical and hematological study of goats envenomed with natural and 60Co-irradiated bothropic venom |
title_full |
Biochemical and hematological study of goats envenomed with natural and 60Co-irradiated bothropic venom |
title_fullStr |
Biochemical and hematological study of goats envenomed with natural and 60Co-irradiated bothropic venom |
title_full_unstemmed |
Biochemical and hematological study of goats envenomed with natural and 60Co-irradiated bothropic venom |
title_sort |
biochemical and hematological study of goats envenomed with natural and 60co-irradiated bothropic venom |
publisher |
SciELO |
publishDate |
2007 |
url |
https://doi.org/10.1590/S1678-91992007000300003 https://doaj.org/article/af1c559467344331ad4ab9f52371cebe |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 13, Iss 3, Pp 576-597 (2007) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000300003 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992007000300003 1678-9199 https://doaj.org/article/af1c559467344331ad4ab9f52371cebe |
op_doi |
https://doi.org/10.1590/S1678-91992007000300003 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
13 |
container_issue |
3 |
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1766339121152786432 |