Context-dependent roles of B cells during intestinal helminth infection.
The current approaches to reduce the burden of chronic helminth infections in endemic areas are adequate sanitation and periodic administration of deworming drugs. Yet, resistance against some deworming drugs and reinfection can still rapidly occur even after treatment. A vaccine against helminths w...
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ftdoajarticles:oai:doaj.org/article:af0853be025b41d1829541c9c44a78f9 2023-05-15T15:04:39+02:00 Context-dependent roles of B cells during intestinal helminth infection. Aidil Zaini Kim L Good-Jacobson Colby Zaph 2021-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009340 https://doaj.org/article/af0853be025b41d1829541c9c44a78f9 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009340 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009340 https://doaj.org/article/af0853be025b41d1829541c9c44a78f9 PLoS Neglected Tropical Diseases, Vol 15, Iss 5, p e0009340 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009340 2022-12-31T11:45:09Z The current approaches to reduce the burden of chronic helminth infections in endemic areas are adequate sanitation and periodic administration of deworming drugs. Yet, resistance against some deworming drugs and reinfection can still rapidly occur even after treatment. A vaccine against helminths would be an effective solution at preventing reinfection. However, vaccines against helminth parasites have yet to be successfully developed. While T helper cells and innate lymphoid cells have been established as important components of the protective type 2 response, the roles of B cells and antibodies remain the most controversial. Here, we review the roles of B cells during intestinal helminth infection. We discuss the potential factors that contribute to the context-specific roles for B cells in protection against diverse intestinal helminth parasite species, using evidence from well-defined murine model systems. Understanding the precise roles of B cells during resistance and susceptibility to helminth infection may offer a new perspective of type 2 protective immunity. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 5 e0009340 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Aidil Zaini Kim L Good-Jacobson Colby Zaph Context-dependent roles of B cells during intestinal helminth infection. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The current approaches to reduce the burden of chronic helminth infections in endemic areas are adequate sanitation and periodic administration of deworming drugs. Yet, resistance against some deworming drugs and reinfection can still rapidly occur even after treatment. A vaccine against helminths would be an effective solution at preventing reinfection. However, vaccines against helminth parasites have yet to be successfully developed. While T helper cells and innate lymphoid cells have been established as important components of the protective type 2 response, the roles of B cells and antibodies remain the most controversial. Here, we review the roles of B cells during intestinal helminth infection. We discuss the potential factors that contribute to the context-specific roles for B cells in protection against diverse intestinal helminth parasite species, using evidence from well-defined murine model systems. Understanding the precise roles of B cells during resistance and susceptibility to helminth infection may offer a new perspective of type 2 protective immunity. |
format |
Article in Journal/Newspaper |
author |
Aidil Zaini Kim L Good-Jacobson Colby Zaph |
author_facet |
Aidil Zaini Kim L Good-Jacobson Colby Zaph |
author_sort |
Aidil Zaini |
title |
Context-dependent roles of B cells during intestinal helminth infection. |
title_short |
Context-dependent roles of B cells during intestinal helminth infection. |
title_full |
Context-dependent roles of B cells during intestinal helminth infection. |
title_fullStr |
Context-dependent roles of B cells during intestinal helminth infection. |
title_full_unstemmed |
Context-dependent roles of B cells during intestinal helminth infection. |
title_sort |
context-dependent roles of b cells during intestinal helminth infection. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009340 https://doaj.org/article/af0853be025b41d1829541c9c44a78f9 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 5, p e0009340 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009340 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009340 https://doaj.org/article/af0853be025b41d1829541c9c44a78f9 |
op_doi |
https://doi.org/10.1371/journal.pntd.0009340 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
15 |
container_issue |
5 |
container_start_page |
e0009340 |
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1766336383841992704 |