Human exposure to zoonotic malaria vectors in village, farm and forest habitats in Sabah, Malaysian Borneo.
The zoonotic malaria parasite, Plasmodium knowlesi, is now a substantial public health problem in Malaysian Borneo. Current understanding of P. knowlesi vector bionomics and ecology in Sabah comes from a few studies near the epicentre of human cases in one district, Kudat. These have incriminated An...
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ftdoajarticles:oai:doaj.org/article:ae47afbdfe1d4f0cb57803e53de878d3 2023-05-15T15:16:16+02:00 Human exposure to zoonotic malaria vectors in village, farm and forest habitats in Sabah, Malaysian Borneo. Rebecca Brown Tock H Chua Kimberly Fornace Chris Drakeley Indra Vythilingam Heather M Ferguson 2020-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008617 https://doaj.org/article/ae47afbdfe1d4f0cb57803e53de878d3 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008617 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008617 https://doaj.org/article/ae47afbdfe1d4f0cb57803e53de878d3 PLoS Neglected Tropical Diseases, Vol 14, Iss 9, p e0008617 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008617 2022-12-31T07:56:47Z The zoonotic malaria parasite, Plasmodium knowlesi, is now a substantial public health problem in Malaysian Borneo. Current understanding of P. knowlesi vector bionomics and ecology in Sabah comes from a few studies near the epicentre of human cases in one district, Kudat. These have incriminated Anopheles balabacensis as the primary vector, and suggest that human exposure to vector biting is peri-domestic as well as in forest environments. To address the limited understanding of vector ecology and human exposure risk outside of Kudat, we performed wider scale surveillance across four districts in Sabah with confirmed transmission to investigate spatial heterogeneity in vector abundance, diversity and infection rate. Entomological surveillance was carried out six months after a cross-sectional survey of P. knowlesi prevalence in humans throughout the study area; providing an opportunity to investigate associations between entomological indicators and infection. Human-landing catches were performed in peri-domestic, farm and forest sites in 11 villages (3-4 per district) and paired with estimates of human P. knowlesi exposure based on sero-prevalence. Anopheles balabacensis was present in all districts but only 6/11 villages. The mean density of An. balabacensis was relatively low, but significantly higher in farm (0.094/night) and forest (0.082/night) than peri-domestic areas (0.007/night). Only one An. balabacensis (n = 32) was infected with P. knowlesi. Plasmodium knowlesi sero-positivity in people was not associated with An. balabacensis density at the village-level however post hoc analyses indicated the study had limited power to detect a statistical association due low vector density. Wider scale sampling revealed substantial heterogeneity in vector density and distribution between villages and districts. Vector-habitat associations predicted from this larger-scale surveillance differed from those inferred from smaller-scale studies in Kudat; highlighting the importance of local ecological context. ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 14 9 e0008617 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Rebecca Brown Tock H Chua Kimberly Fornace Chris Drakeley Indra Vythilingam Heather M Ferguson Human exposure to zoonotic malaria vectors in village, farm and forest habitats in Sabah, Malaysian Borneo. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The zoonotic malaria parasite, Plasmodium knowlesi, is now a substantial public health problem in Malaysian Borneo. Current understanding of P. knowlesi vector bionomics and ecology in Sabah comes from a few studies near the epicentre of human cases in one district, Kudat. These have incriminated Anopheles balabacensis as the primary vector, and suggest that human exposure to vector biting is peri-domestic as well as in forest environments. To address the limited understanding of vector ecology and human exposure risk outside of Kudat, we performed wider scale surveillance across four districts in Sabah with confirmed transmission to investigate spatial heterogeneity in vector abundance, diversity and infection rate. Entomological surveillance was carried out six months after a cross-sectional survey of P. knowlesi prevalence in humans throughout the study area; providing an opportunity to investigate associations between entomological indicators and infection. Human-landing catches were performed in peri-domestic, farm and forest sites in 11 villages (3-4 per district) and paired with estimates of human P. knowlesi exposure based on sero-prevalence. Anopheles balabacensis was present in all districts but only 6/11 villages. The mean density of An. balabacensis was relatively low, but significantly higher in farm (0.094/night) and forest (0.082/night) than peri-domestic areas (0.007/night). Only one An. balabacensis (n = 32) was infected with P. knowlesi. Plasmodium knowlesi sero-positivity in people was not associated with An. balabacensis density at the village-level however post hoc analyses indicated the study had limited power to detect a statistical association due low vector density. Wider scale sampling revealed substantial heterogeneity in vector density and distribution between villages and districts. Vector-habitat associations predicted from this larger-scale surveillance differed from those inferred from smaller-scale studies in Kudat; highlighting the importance of local ecological context. ... |
format |
Article in Journal/Newspaper |
author |
Rebecca Brown Tock H Chua Kimberly Fornace Chris Drakeley Indra Vythilingam Heather M Ferguson |
author_facet |
Rebecca Brown Tock H Chua Kimberly Fornace Chris Drakeley Indra Vythilingam Heather M Ferguson |
author_sort |
Rebecca Brown |
title |
Human exposure to zoonotic malaria vectors in village, farm and forest habitats in Sabah, Malaysian Borneo. |
title_short |
Human exposure to zoonotic malaria vectors in village, farm and forest habitats in Sabah, Malaysian Borneo. |
title_full |
Human exposure to zoonotic malaria vectors in village, farm and forest habitats in Sabah, Malaysian Borneo. |
title_fullStr |
Human exposure to zoonotic malaria vectors in village, farm and forest habitats in Sabah, Malaysian Borneo. |
title_full_unstemmed |
Human exposure to zoonotic malaria vectors in village, farm and forest habitats in Sabah, Malaysian Borneo. |
title_sort |
human exposure to zoonotic malaria vectors in village, farm and forest habitats in sabah, malaysian borneo. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008617 https://doaj.org/article/ae47afbdfe1d4f0cb57803e53de878d3 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 9, p e0008617 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008617 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008617 https://doaj.org/article/ae47afbdfe1d4f0cb57803e53de878d3 |
op_doi |
https://doi.org/10.1371/journal.pntd.0008617 |
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PLOS Neglected Tropical Diseases |
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e0008617 |
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