Resistance of Streptococcus pneumoniae to antimicrobials in São Paulo, Brazil: clinical features and serotypes Resistência antimicrobiana de Streptococcus pneumoniae em São Paulo, Brasil: quadro clínico e sorotipos

• Published in: Revista do Instituto de Medicina Tropical de São Paulo
• Main Authors: Anna Sara S. Levin, Lucia Martins Teixeira, Juliana Furian Sessegolo, Antonio Alci Barone
• Format: Article in Journal/Newspaper
• Language: English
• Published: Universidade de São Paulo (USP) 1996
• Subjects: Streptococcus pneumoniae; Pneumococcal infections; Resistance; Serotypes; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic
• Online Access: https://doi.org/10.1590/S0036-46651996000300004; https://doaj.org/article/ae3d848c1f8548e69da62f88edbc9e29

To study resistance to antimicrobials, serotypes and clinical features of S. pneumoniae in S. Paulo, Brazil, 50 patients with a positive culture were evaluated: 7 were considered carriers and 43 had pneumococcal infections. Pneumonia and meningitis were the most commom infections. Mortality was 34% and underlying diseases were present in 70%. Relative resistance to penicillin occurred in 24% and complete resistance was not detected. Resistance to tetracycline was 32% and to sulfamethoxazole/trimethoprim 32%; one strain had intermediate susceptibility to erythromycin; no resistance was present for chloramphenicol, rifampin or vancomycin. Resistance to at least one of the drugs tested occurred in 62%. Results by the E-test for penicillin were similar to those by the agar dilution method. There were 24 different serotypes and 74% of the strains belonged to the 23-valent vaccine including all the penicillin-resistant strains. In this study S. pneumoniae caused severe infections and presented a high resistance rate to commonly used antimicrobials. Routine surveillance of resistance and the use of vaccination, as well as the restriction of inappropriate use of antimicrobials, are recommended in São Paulo, Brazil. Com a finalidade de estudar resistência a antimicrobianos, sorotipos e quadro clínico de Streptococcus pneumoniae em São Paulo, Brasil, foram avaliados 50 pacientes com culturas positivas: 7 foram considerados portadores e 43 infectados. Pneumonia e meningite foram as infecções mais freqüentes. A letalidade foi de 34% e doenças de base estiveram presentes em 70%. Resistência relativa a penicilina ocorreu em 24% e a resistência completa não foi detectada. Resistência a tetraciclina ocorreu em 32% e a sulfametoxazol/trimetoprim em 32% e houve uma cepa com sensibilidade intermediária a eritromicina. Não houve resistência a cloranfenicol, rifampicina ou vancomicina. Em 62% dos casos houve resistência a pelo menos uma das drogas testadas. Resultados de sensibilidade utilizando o E-teste resultaram semelhantes aos ...