A newly emerged cutaneous leishmaniasis focus in northern Israel and two new reservoir hosts of Leishmania major.
In 2006/7, 18 cases of cutaneous leishmaniasis (CL) were reported for the first time from Sde Eliyahu (pop. 650), a village in the Beit She'an valley of Israel. Between 2007-2011, a further 88 CL cases were diagnosed bringing the total to 106 (16.3% of the population of Sde Eliyahu). The majori...
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ftdoajarticles:oai:doaj.org/article:adff22b9dfa34561ae0be4aa768312f3 2023-05-15T15:18:40+02:00 A newly emerged cutaneous leishmaniasis focus in northern Israel and two new reservoir hosts of Leishmania major. Roy Faiman Ibrahim Abbasi Charles Jaffe Yoav Motro Abdelmagid Nasereddin Lionel F Schnur Moshe Torem Francine Pratlong Jean-Pierre Dedet Alon Warburg 2013-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002058 https://doaj.org/article/adff22b9dfa34561ae0be4aa768312f3 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3578753?pdf=render https://doaj.org/toc/1935-2735 1935-2735 doi:10.1371/journal.pntd.0002058 https://doaj.org/article/adff22b9dfa34561ae0be4aa768312f3 PLoS Neglected Tropical Diseases, Vol 7, Iss 2, p e2058 (2013) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2013 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002058 2022-12-31T14:25:40Z In 2006/7, 18 cases of cutaneous leishmaniasis (CL) were reported for the first time from Sde Eliyahu (pop. 650), a village in the Beit She'an valley of Israel. Between 2007-2011, a further 88 CL cases were diagnosed bringing the total to 106 (16.3% of the population of Sde Eliyahu). The majority of cases resided in the south-western part of the village along the perimeter fence. The causative parasite was identified as Leishmania major Yakimoff & Schokhor, 1914 (Kinetoplastida: Trypanosomatidae). Phlebotomus papatasi (Scopoli), 1786 (Diptera: Psychodidae) was found to be the most abundant phlebotomine species comprising 97% of the sand flies trapped inside the village, and an average of 7.9% of the females were positive for Leishmania ITS1 DNA. Parasite isolates from CL cases and a sand fly were characterized using several methods and shown to be L. major. During a comprehensive survey of rodents 164 Levant voles Microtus guentheri Danford & Alston, 1880 (Rodentia: Cricetidae) were captured in alfalfa fields bordering the village. Of these 27 (16.5%) tested positive for Leishmania ITS1 DNA and shown to be L. major by reverse line blotting. A very high percentage (58.3%-21/36) of Tristram's jirds Meriones tristrami Thomas, 1892 (Rodentia: Muridae), found further away from the village also tested positive for ITS1 by PCR. Isolates of L. major were successfully cultured from the ear of a wild jird found positive by ITS1 PCR. Although none of the wild PCR-positive voles exhibited external pathology, laboratory-reared voles that were infected by intradermal L. major inoculation, developed patent lesions and sand flies became infected by feeding on the ears of these laboratory-infected voles. This is the first report implicating M. guentheri and M. tristrami as reservoirs of Leishmania. The widespread co-distribution of M. guentheri and P. papatasi, suggests a significant threat from the spread of CL caused by L. major in the Middle East, central Asia and southern Europe. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 7 2 e2058 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Roy Faiman Ibrahim Abbasi Charles Jaffe Yoav Motro Abdelmagid Nasereddin Lionel F Schnur Moshe Torem Francine Pratlong Jean-Pierre Dedet Alon Warburg A newly emerged cutaneous leishmaniasis focus in northern Israel and two new reservoir hosts of Leishmania major. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
In 2006/7, 18 cases of cutaneous leishmaniasis (CL) were reported for the first time from Sde Eliyahu (pop. 650), a village in the Beit She'an valley of Israel. Between 2007-2011, a further 88 CL cases were diagnosed bringing the total to 106 (16.3% of the population of Sde Eliyahu). The majority of cases resided in the south-western part of the village along the perimeter fence. The causative parasite was identified as Leishmania major Yakimoff & Schokhor, 1914 (Kinetoplastida: Trypanosomatidae). Phlebotomus papatasi (Scopoli), 1786 (Diptera: Psychodidae) was found to be the most abundant phlebotomine species comprising 97% of the sand flies trapped inside the village, and an average of 7.9% of the females were positive for Leishmania ITS1 DNA. Parasite isolates from CL cases and a sand fly were characterized using several methods and shown to be L. major. During a comprehensive survey of rodents 164 Levant voles Microtus guentheri Danford & Alston, 1880 (Rodentia: Cricetidae) were captured in alfalfa fields bordering the village. Of these 27 (16.5%) tested positive for Leishmania ITS1 DNA and shown to be L. major by reverse line blotting. A very high percentage (58.3%-21/36) of Tristram's jirds Meriones tristrami Thomas, 1892 (Rodentia: Muridae), found further away from the village also tested positive for ITS1 by PCR. Isolates of L. major were successfully cultured from the ear of a wild jird found positive by ITS1 PCR. Although none of the wild PCR-positive voles exhibited external pathology, laboratory-reared voles that were infected by intradermal L. major inoculation, developed patent lesions and sand flies became infected by feeding on the ears of these laboratory-infected voles. This is the first report implicating M. guentheri and M. tristrami as reservoirs of Leishmania. The widespread co-distribution of M. guentheri and P. papatasi, suggests a significant threat from the spread of CL caused by L. major in the Middle East, central Asia and southern Europe. |
format |
Article in Journal/Newspaper |
author |
Roy Faiman Ibrahim Abbasi Charles Jaffe Yoav Motro Abdelmagid Nasereddin Lionel F Schnur Moshe Torem Francine Pratlong Jean-Pierre Dedet Alon Warburg |
author_facet |
Roy Faiman Ibrahim Abbasi Charles Jaffe Yoav Motro Abdelmagid Nasereddin Lionel F Schnur Moshe Torem Francine Pratlong Jean-Pierre Dedet Alon Warburg |
author_sort |
Roy Faiman |
title |
A newly emerged cutaneous leishmaniasis focus in northern Israel and two new reservoir hosts of Leishmania major. |
title_short |
A newly emerged cutaneous leishmaniasis focus in northern Israel and two new reservoir hosts of Leishmania major. |
title_full |
A newly emerged cutaneous leishmaniasis focus in northern Israel and two new reservoir hosts of Leishmania major. |
title_fullStr |
A newly emerged cutaneous leishmaniasis focus in northern Israel and two new reservoir hosts of Leishmania major. |
title_full_unstemmed |
A newly emerged cutaneous leishmaniasis focus in northern Israel and two new reservoir hosts of Leishmania major. |
title_sort |
newly emerged cutaneous leishmaniasis focus in northern israel and two new reservoir hosts of leishmania major. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2013 |
url |
https://doi.org/10.1371/journal.pntd.0002058 https://doaj.org/article/adff22b9dfa34561ae0be4aa768312f3 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 7, Iss 2, p e2058 (2013) |
op_relation |
http://europepmc.org/articles/PMC3578753?pdf=render https://doaj.org/toc/1935-2735 1935-2735 doi:10.1371/journal.pntd.0002058 https://doaj.org/article/adff22b9dfa34561ae0be4aa768312f3 |
op_doi |
https://doi.org/10.1371/journal.pntd.0002058 |
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PLoS Neglected Tropical Diseases |
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7 |
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2 |
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e2058 |
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1766348854573137920 |