Biochemical and pharmacological study of venom of the wolf spider Lycosa singoriensis
The wolf spider Lycosa singoriensis is a large and venomous spider distributed throughout northwestern China. Like other spider venoms, the wolf spider venom is a chemical cocktail. Its protein content is 0.659 mg protein/mg crude venom as determined by the Lowry method. MALDI-TOF analysis revealed...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:adeb2a3b66d54f6ea9844525bea91e85 2023-05-15T15:03:27+02:00 Biochemical and pharmacological study of venom of the wolf spider Lycosa singoriensis ZH Liu W Qian J Li Y Zhang S Liang 2009-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992009000100008 https://doaj.org/article/adeb2a3b66d54f6ea9844525bea91e85 EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000100008 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992009000100008 1678-9199 https://doaj.org/article/adeb2a3b66d54f6ea9844525bea91e85 Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 15, Iss 1, Pp 79-92 (2009) spider Lycosa singoriensis crude venom MALDI-TOF antimicrobial activity Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2009 ftdoajarticles https://doi.org/10.1590/S1678-91992009000100008 2022-12-31T16:01:15Z The wolf spider Lycosa singoriensis is a large and venomous spider distributed throughout northwestern China. Like other spider venoms, the wolf spider venom is a chemical cocktail. Its protein content is 0.659 mg protein/mg crude venom as determined by the Lowry method. MALDI-TOF analysis revealed that the venom peptides are highly diverse and may be divided into three groups characterized by three independent molecular ranges: 2,000 to 2,500 Da, 4,800 to 5,500 Da and 7,000 to 8,000 Da, respectively. This molecular distribution differs substantially from those of most spider venoms studied so far. This wolf spider venom has low neurotoxic action on mice, but it can induce hemolysis of human erythrocytes. Furthermore, the venom shows antimicrobial activity against prokaryotic and eukaryotic cells. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Lowry ENVELOPE(-64.150,-64.150,-84.550,-84.550) Journal of Venomous Animals and Toxins including Tropical Diseases 15 1 79 92 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
spider Lycosa singoriensis crude venom MALDI-TOF antimicrobial activity Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
spider Lycosa singoriensis crude venom MALDI-TOF antimicrobial activity Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 ZH Liu W Qian J Li Y Zhang S Liang Biochemical and pharmacological study of venom of the wolf spider Lycosa singoriensis |
topic_facet |
spider Lycosa singoriensis crude venom MALDI-TOF antimicrobial activity Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
The wolf spider Lycosa singoriensis is a large and venomous spider distributed throughout northwestern China. Like other spider venoms, the wolf spider venom is a chemical cocktail. Its protein content is 0.659 mg protein/mg crude venom as determined by the Lowry method. MALDI-TOF analysis revealed that the venom peptides are highly diverse and may be divided into three groups characterized by three independent molecular ranges: 2,000 to 2,500 Da, 4,800 to 5,500 Da and 7,000 to 8,000 Da, respectively. This molecular distribution differs substantially from those of most spider venoms studied so far. This wolf spider venom has low neurotoxic action on mice, but it can induce hemolysis of human erythrocytes. Furthermore, the venom shows antimicrobial activity against prokaryotic and eukaryotic cells. |
format |
Article in Journal/Newspaper |
author |
ZH Liu W Qian J Li Y Zhang S Liang |
author_facet |
ZH Liu W Qian J Li Y Zhang S Liang |
author_sort |
ZH Liu |
title |
Biochemical and pharmacological study of venom of the wolf spider Lycosa singoriensis |
title_short |
Biochemical and pharmacological study of venom of the wolf spider Lycosa singoriensis |
title_full |
Biochemical and pharmacological study of venom of the wolf spider Lycosa singoriensis |
title_fullStr |
Biochemical and pharmacological study of venom of the wolf spider Lycosa singoriensis |
title_full_unstemmed |
Biochemical and pharmacological study of venom of the wolf spider Lycosa singoriensis |
title_sort |
biochemical and pharmacological study of venom of the wolf spider lycosa singoriensis |
publisher |
SciELO |
publishDate |
2009 |
url |
https://doi.org/10.1590/S1678-91992009000100008 https://doaj.org/article/adeb2a3b66d54f6ea9844525bea91e85 |
long_lat |
ENVELOPE(-64.150,-64.150,-84.550,-84.550) |
geographic |
Arctic Lowry |
geographic_facet |
Arctic Lowry |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 15, Iss 1, Pp 79-92 (2009) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000100008 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992009000100008 1678-9199 https://doaj.org/article/adeb2a3b66d54f6ea9844525bea91e85 |
op_doi |
https://doi.org/10.1590/S1678-91992009000100008 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
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15 |
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1 |
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79 |
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92 |
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