Decoding the similarities and differences among mycobacterial species.
Mycobacteriaceae comprises pathogenic species such as Mycobacterium tuberculosis, M. leprae and M. abscessus, as well as non-pathogenic species, for example, M. smegmatis and M. thermoresistibile. Genome comparison and annotation studies provide insights into genome evolutionary relatedness, identif...
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ftdoajarticles:oai:doaj.org/article:adaeed619e7d485fa35eb02e671ed580 2023-05-15T15:07:18+02:00 Decoding the similarities and differences among mycobacterial species. Sony Malhotra Sundeep Chaitanya Vedithi Tom L Blundell 2017-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005883 https://doaj.org/article/adaeed619e7d485fa35eb02e671ed580 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5595346?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005883 https://doaj.org/article/adaeed619e7d485fa35eb02e671ed580 PLoS Neglected Tropical Diseases, Vol 11, Iss 8, p e0005883 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005883 2022-12-31T05:43:59Z Mycobacteriaceae comprises pathogenic species such as Mycobacterium tuberculosis, M. leprae and M. abscessus, as well as non-pathogenic species, for example, M. smegmatis and M. thermoresistibile. Genome comparison and annotation studies provide insights into genome evolutionary relatedness, identify unique and pathogenicity-related genes in each species, and explore new targets that could be used for developing new diagnostics and therapeutics. Here, we present a comparative analysis of ten-mycobacterial genomes with the objective of identifying similarities and differences between pathogenic and non-pathogenic species. We identified 1080 core orthologous clusters that were enriched in proteins involved in amino acid and purine/pyrimidine biosynthetic pathways, DNA-related processes (replication, transcription, recombination and repair), RNA-methylation and modification, and cell-wall polysaccharide biosynthetic pathways. For their pathogenicity and survival in the host cell, pathogenic species have gained specific sets of genes involved in repair and protection of their genomic DNA. M. leprae is of special interest owing to its smallest genome (1600 genes and ~1300 psuedogenes), yet poor genome annotation. More than 75% of the pseudogenes were found to have a functional ortholog in the other mycobacterial genomes and belong to protein families such as transferases, oxidoreductases and hydrolases. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 8 e0005883 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Sony Malhotra Sundeep Chaitanya Vedithi Tom L Blundell Decoding the similarities and differences among mycobacterial species. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Mycobacteriaceae comprises pathogenic species such as Mycobacterium tuberculosis, M. leprae and M. abscessus, as well as non-pathogenic species, for example, M. smegmatis and M. thermoresistibile. Genome comparison and annotation studies provide insights into genome evolutionary relatedness, identify unique and pathogenicity-related genes in each species, and explore new targets that could be used for developing new diagnostics and therapeutics. Here, we present a comparative analysis of ten-mycobacterial genomes with the objective of identifying similarities and differences between pathogenic and non-pathogenic species. We identified 1080 core orthologous clusters that were enriched in proteins involved in amino acid and purine/pyrimidine biosynthetic pathways, DNA-related processes (replication, transcription, recombination and repair), RNA-methylation and modification, and cell-wall polysaccharide biosynthetic pathways. For their pathogenicity and survival in the host cell, pathogenic species have gained specific sets of genes involved in repair and protection of their genomic DNA. M. leprae is of special interest owing to its smallest genome (1600 genes and ~1300 psuedogenes), yet poor genome annotation. More than 75% of the pseudogenes were found to have a functional ortholog in the other mycobacterial genomes and belong to protein families such as transferases, oxidoreductases and hydrolases. |
format |
Article in Journal/Newspaper |
author |
Sony Malhotra Sundeep Chaitanya Vedithi Tom L Blundell |
author_facet |
Sony Malhotra Sundeep Chaitanya Vedithi Tom L Blundell |
author_sort |
Sony Malhotra |
title |
Decoding the similarities and differences among mycobacterial species. |
title_short |
Decoding the similarities and differences among mycobacterial species. |
title_full |
Decoding the similarities and differences among mycobacterial species. |
title_fullStr |
Decoding the similarities and differences among mycobacterial species. |
title_full_unstemmed |
Decoding the similarities and differences among mycobacterial species. |
title_sort |
decoding the similarities and differences among mycobacterial species. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005883 https://doaj.org/article/adaeed619e7d485fa35eb02e671ed580 |
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Arctic |
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Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 8, p e0005883 (2017) |
op_relation |
http://europepmc.org/articles/PMC5595346?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005883 https://doaj.org/article/adaeed619e7d485fa35eb02e671ed580 |
op_doi |
https://doi.org/10.1371/journal.pntd.0005883 |
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PLOS Neglected Tropical Diseases |
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11 |
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8 |
container_start_page |
e0005883 |
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1766338830797897728 |