Thyroid autoimmunity in Greenlandic Inuit
Objective: This study aimed to provide the first data on the occurrence of thyroid autoimmunity among Inuit in Greenland, a distinct ethnic group who is not iodine deficient. Design: This study is a population-based cross-sectional study. Methods: Data were collected in Nuuk in West Greenland and in...
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Bioscientifica
2023
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ftdoajarticles:oai:doaj.org/article:ad80b39117a5486bb5ed70ed38416f2c 2023-05-15T15:11:45+02:00 Thyroid autoimmunity in Greenlandic Inuit Paneeraq Noahsen Karsten F Rex Inge Bülow Pedersen Gert Mulvad Hans Christian Florian-Sørensen Michael Lynge Pedersen Stig Andersen 2023-01-01T00:00:00Z https://doi.org/10.1530/ETJ-22-0071 https://doaj.org/article/ad80b39117a5486bb5ed70ed38416f2c EN eng Bioscientifica https://etj.bioscientifica.com/view/journals/etj/11/3/ETJ-22-0071.xml https://doaj.org/toc/2235-0802 https://doi.org/10.1530/ETJ-22-0071 2235-0802 https://doaj.org/article/ad80b39117a5486bb5ed70ed38416f2c European Thyroid Journal, Vol 11, Iss 3, Pp 1-9 (2023) thyroid autoimmunity iodine excretion greenland inuit arctic environment Diseases of the endocrine glands. Clinical endocrinology RC648-665 article 2023 ftdoajarticles https://doi.org/10.1530/ETJ-22-0071 2023-01-15T01:25:45Z Objective: This study aimed to provide the first data on the occurrence of thyroid autoimmunity among Inuit in Greenland, a distinct ethnic group who is not iodine deficient. Design: This study is a population-based cross-sectional study. Methods: Data were collected in Nuuk in West Greenland and in Ammassali k district in East Greenland. Information on lifestyle, diet and diseases was obtained using questionnaires. Thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TGAb) and thyroid-stimulating hormone (TSH) were measured in serum. Iodin e and creatinine were measured in spot urine samples. Results: The participation rate was 95% with 434 Inuit participants; 75 % were smokers. Iodine excretion was 169 μg/24 h in urban West Greenland, 224 μ g/24 h in the main town and 228 μg/24 h in settlements in rural East Greenland. TP OAb, TgAb or either of these was measured in the serum from 3.7, 5.9 and 8.3% of parti cipants, respectively. TPOAb or TgAb was found in 9.3% of Inuit women and 7.5% of men and more frequently, in East Greenland Inuit with the higher iodine excretion ( P = 0.02). There was some evidence suggesting that thyroid autoimmunity was more frequent among non-smokers (12.5%) compared to smokers (7.0%). Harbouring a thyroid autoan tibody was most frequent in participants with TSH above 3.6 mIU/L (P < 0.001). Conclusion: Thyroid autoantibodies were rare among Greenland Inuit. While iodine nutrition was associated with autoimmunity similarly to other e thnic groups, the influence of sex and smoking was limited. This could suggest gen etic component in Inuit, but the impact of cold, selenium and persistent organic pollutants needs to be elucidated. Article in Journal/Newspaper Arctic East Greenland Greenland greenlandic inuit Nuuk Directory of Open Access Journals: DOAJ Articles Arctic Greenland Nuuk ENVELOPE(-52.150,-52.150,68.717,68.717) European Thyroid Journal 11 3 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
thyroid autoimmunity iodine excretion greenland inuit arctic environment Diseases of the endocrine glands. Clinical endocrinology RC648-665 |
spellingShingle |
thyroid autoimmunity iodine excretion greenland inuit arctic environment Diseases of the endocrine glands. Clinical endocrinology RC648-665 Paneeraq Noahsen Karsten F Rex Inge Bülow Pedersen Gert Mulvad Hans Christian Florian-Sørensen Michael Lynge Pedersen Stig Andersen Thyroid autoimmunity in Greenlandic Inuit |
topic_facet |
thyroid autoimmunity iodine excretion greenland inuit arctic environment Diseases of the endocrine glands. Clinical endocrinology RC648-665 |
description |
Objective: This study aimed to provide the first data on the occurrence of thyroid autoimmunity among Inuit in Greenland, a distinct ethnic group who is not iodine deficient. Design: This study is a population-based cross-sectional study. Methods: Data were collected in Nuuk in West Greenland and in Ammassali k district in East Greenland. Information on lifestyle, diet and diseases was obtained using questionnaires. Thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TGAb) and thyroid-stimulating hormone (TSH) were measured in serum. Iodin e and creatinine were measured in spot urine samples. Results: The participation rate was 95% with 434 Inuit participants; 75 % were smokers. Iodine excretion was 169 μg/24 h in urban West Greenland, 224 μ g/24 h in the main town and 228 μg/24 h in settlements in rural East Greenland. TP OAb, TgAb or either of these was measured in the serum from 3.7, 5.9 and 8.3% of parti cipants, respectively. TPOAb or TgAb was found in 9.3% of Inuit women and 7.5% of men and more frequently, in East Greenland Inuit with the higher iodine excretion ( P = 0.02). There was some evidence suggesting that thyroid autoimmunity was more frequent among non-smokers (12.5%) compared to smokers (7.0%). Harbouring a thyroid autoan tibody was most frequent in participants with TSH above 3.6 mIU/L (P < 0.001). Conclusion: Thyroid autoantibodies were rare among Greenland Inuit. While iodine nutrition was associated with autoimmunity similarly to other e thnic groups, the influence of sex and smoking was limited. This could suggest gen etic component in Inuit, but the impact of cold, selenium and persistent organic pollutants needs to be elucidated. |
format |
Article in Journal/Newspaper |
author |
Paneeraq Noahsen Karsten F Rex Inge Bülow Pedersen Gert Mulvad Hans Christian Florian-Sørensen Michael Lynge Pedersen Stig Andersen |
author_facet |
Paneeraq Noahsen Karsten F Rex Inge Bülow Pedersen Gert Mulvad Hans Christian Florian-Sørensen Michael Lynge Pedersen Stig Andersen |
author_sort |
Paneeraq Noahsen |
title |
Thyroid autoimmunity in Greenlandic Inuit |
title_short |
Thyroid autoimmunity in Greenlandic Inuit |
title_full |
Thyroid autoimmunity in Greenlandic Inuit |
title_fullStr |
Thyroid autoimmunity in Greenlandic Inuit |
title_full_unstemmed |
Thyroid autoimmunity in Greenlandic Inuit |
title_sort |
thyroid autoimmunity in greenlandic inuit |
publisher |
Bioscientifica |
publishDate |
2023 |
url |
https://doi.org/10.1530/ETJ-22-0071 https://doaj.org/article/ad80b39117a5486bb5ed70ed38416f2c |
long_lat |
ENVELOPE(-52.150,-52.150,68.717,68.717) |
geographic |
Arctic Greenland Nuuk |
geographic_facet |
Arctic Greenland Nuuk |
genre |
Arctic East Greenland Greenland greenlandic inuit Nuuk |
genre_facet |
Arctic East Greenland Greenland greenlandic inuit Nuuk |
op_source |
European Thyroid Journal, Vol 11, Iss 3, Pp 1-9 (2023) |
op_relation |
https://etj.bioscientifica.com/view/journals/etj/11/3/ETJ-22-0071.xml https://doaj.org/toc/2235-0802 https://doi.org/10.1530/ETJ-22-0071 2235-0802 https://doaj.org/article/ad80b39117a5486bb5ed70ed38416f2c |
op_doi |
https://doi.org/10.1530/ETJ-22-0071 |
container_title |
European Thyroid Journal |
container_volume |
11 |
container_issue |
3 |
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1766342554785153024 |