Epidemiology of Japanese encephalitis in the Philippines: a systematic review.
BACKGROUND:Japanese encephalitis virus (JEV) is an important cause of encephalitis in most of Asia, with high case fatality rates and often significant neurologic sequelae among survivors. The epidemiology of JE in the Philippines is not well defined. To support consideration of JE vaccine for intro...
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ftdoajarticles:oai:doaj.org/article:ad550f0df6674b89bcf7774921bbc560 2023-05-15T15:14:18+02:00 Epidemiology of Japanese encephalitis in the Philippines: a systematic review. Anna Lena Lopez Josephine G Aldaba Vito G Roque Amado O Tandoc Ava Kristy Sy Fe Esperanza Espino Maricel DeQuiroz-Castro Youngmee Jee Maria Joyce Ducusin Kimberley K Fox 2015-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0003630 https://doaj.org/article/ad550f0df6674b89bcf7774921bbc560 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4367992?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003630 https://doaj.org/article/ad550f0df6674b89bcf7774921bbc560 PLoS Neglected Tropical Diseases, Vol 9, Iss 3, p e0003630 (2015) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2015 ftdoajarticles https://doi.org/10.1371/journal.pntd.0003630 2022-12-31T05:36:28Z BACKGROUND:Japanese encephalitis virus (JEV) is an important cause of encephalitis in most of Asia, with high case fatality rates and often significant neurologic sequelae among survivors. The epidemiology of JE in the Philippines is not well defined. To support consideration of JE vaccine for introduction into the national schedule in the Philippines, we conducted a systematic literature review and summarized JE surveillance data from 2011 to 2014. METHODS:We conducted searches on Japanese encephalitis and the Philippines in four databases and one library. Data from acute encephalitis syndrome (AES) and JE surveillance and from the national reference laboratory from January 2011 to March 2014 were tabulated and mapped. RESULTS:We identified 29 published reports and presentations on JE in the Philippines, including 5 serologic surveys, 18 reports of clinical cases, and 8 animal studies (including two with both clinical cases and animal data). The 18 clinical studies reported 257 cases of laboratory-confirmed JE from 1972 to 2013. JE virus (JEV) was the causative agent in 7% to 18% of cases of clinical meningitis and encephalitis combined, and 16% to 40% of clinical encephalitis cases. JE predominantly affected children under 15 years of age and 6% to 7% of cases resulted in death. Surveillance data from January 2011 to March 2014 identified 73 (15%) laboratory-confirmed JE cases out of 497 cases tested. SUMMARY:This comprehensive review demonstrates the endemicity and extensive geographic range of JE in the Philippines, and supports the use of JE vaccine in the country. Continued and improved surveillance with laboratory confirmation is needed to systematically quantify the burden of JE, to provide information that can guide prioritization of high risk areas in the country and determination of appropriate age and schedule of vaccine introduction, and to measure the impact of preventive measures including immunization against this important public health threat. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 9 3 e0003630 |
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Directory of Open Access Journals: DOAJ Articles |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Anna Lena Lopez Josephine G Aldaba Vito G Roque Amado O Tandoc Ava Kristy Sy Fe Esperanza Espino Maricel DeQuiroz-Castro Youngmee Jee Maria Joyce Ducusin Kimberley K Fox Epidemiology of Japanese encephalitis in the Philippines: a systematic review. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Japanese encephalitis virus (JEV) is an important cause of encephalitis in most of Asia, with high case fatality rates and often significant neurologic sequelae among survivors. The epidemiology of JE in the Philippines is not well defined. To support consideration of JE vaccine for introduction into the national schedule in the Philippines, we conducted a systematic literature review and summarized JE surveillance data from 2011 to 2014. METHODS:We conducted searches on Japanese encephalitis and the Philippines in four databases and one library. Data from acute encephalitis syndrome (AES) and JE surveillance and from the national reference laboratory from January 2011 to March 2014 were tabulated and mapped. RESULTS:We identified 29 published reports and presentations on JE in the Philippines, including 5 serologic surveys, 18 reports of clinical cases, and 8 animal studies (including two with both clinical cases and animal data). The 18 clinical studies reported 257 cases of laboratory-confirmed JE from 1972 to 2013. JE virus (JEV) was the causative agent in 7% to 18% of cases of clinical meningitis and encephalitis combined, and 16% to 40% of clinical encephalitis cases. JE predominantly affected children under 15 years of age and 6% to 7% of cases resulted in death. Surveillance data from January 2011 to March 2014 identified 73 (15%) laboratory-confirmed JE cases out of 497 cases tested. SUMMARY:This comprehensive review demonstrates the endemicity and extensive geographic range of JE in the Philippines, and supports the use of JE vaccine in the country. Continued and improved surveillance with laboratory confirmation is needed to systematically quantify the burden of JE, to provide information that can guide prioritization of high risk areas in the country and determination of appropriate age and schedule of vaccine introduction, and to measure the impact of preventive measures including immunization against this important public health threat. |
format |
Article in Journal/Newspaper |
author |
Anna Lena Lopez Josephine G Aldaba Vito G Roque Amado O Tandoc Ava Kristy Sy Fe Esperanza Espino Maricel DeQuiroz-Castro Youngmee Jee Maria Joyce Ducusin Kimberley K Fox |
author_facet |
Anna Lena Lopez Josephine G Aldaba Vito G Roque Amado O Tandoc Ava Kristy Sy Fe Esperanza Espino Maricel DeQuiroz-Castro Youngmee Jee Maria Joyce Ducusin Kimberley K Fox |
author_sort |
Anna Lena Lopez |
title |
Epidemiology of Japanese encephalitis in the Philippines: a systematic review. |
title_short |
Epidemiology of Japanese encephalitis in the Philippines: a systematic review. |
title_full |
Epidemiology of Japanese encephalitis in the Philippines: a systematic review. |
title_fullStr |
Epidemiology of Japanese encephalitis in the Philippines: a systematic review. |
title_full_unstemmed |
Epidemiology of Japanese encephalitis in the Philippines: a systematic review. |
title_sort |
epidemiology of japanese encephalitis in the philippines: a systematic review. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://doi.org/10.1371/journal.pntd.0003630 https://doaj.org/article/ad550f0df6674b89bcf7774921bbc560 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 9, Iss 3, p e0003630 (2015) |
op_relation |
http://europepmc.org/articles/PMC4367992?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003630 https://doaj.org/article/ad550f0df6674b89bcf7774921bbc560 |
op_doi |
https://doi.org/10.1371/journal.pntd.0003630 |
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PLOS Neglected Tropical Diseases |
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9 |
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3 |
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e0003630 |
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1766344760423874560 |